SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nq5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 11 PHE A 233
TYR A 219
PHE A 112
VAL A 161
PHE A 170
None
1.41A 1q23L-2nq5A:
undetectable
1q23L-2nq5A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
3 / 3 THR A 548
THR A 546
PRO A 544
None
0.85A 1qfiB-2nq5A:
undetectable
1qfiB-2nq5A:
3.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 12 VAL A 383
ILE A 511
GLY A 489
ALA A 488
LEU A 385
None
1.02A 1r9oA-2nq5A:
undetectable
1r9oA-2nq5A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 10 ILE A 269
ALA A 273
LEU A 240
ILE A 279
THR A 271
None
1.25A 1rb3A-2nq5A:
undetectable
1rb3A-2nq5A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
3 / 3 ILE A 570
ILE A 566
THR A 618
None
0.49A 1rg7A-2nq5A:
undetectable
1rg7A-2nq5A:
12.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
7 / 8 ARG A  16
ASN A 115
HIS A 117
SER A 500
ARG A 504
VAL A 506
TRP A 550
None
0.90A 1u1jA-2nq5A:
50.7
1u1jA-2nq5A:
46.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
7 / 8 ARG A  16
LYS A  19
ASN A 115
HIS A 117
ARG A 504
VAL A 506
TRP A 550
None
0.75A 1u1jA-2nq5A:
50.7
1u1jA-2nq5A:
46.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XPG_B_C2FB1883_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 10 ARG A  16
LYS A  19
TRP A 497
ARG A 504
TRP A 550
None
0.87A 1xpgB-2nq5A:
50.4
1xpgB-2nq5A:
43.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XPG_B_C2FB1883_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 10 ARG A  16
TRP A 497
SER A 500
ARG A 504
TRP A 550
None
1.03A 1xpgB-2nq5A:
50.4
1xpgB-2nq5A:
43.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
3 / 3 THR A 546
PRO A 544
THR A 548
None
0.76A 209dC-2nq5A:
undetectable
209dC-2nq5A:
3.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 7 SER A  64
ASP A  71
LEU A 138
GLU A 141
None
0.94A 2cdqB-2nq5A:
undetectable
2cdqB-2nq5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 6 LEU A 311
ILE A 313
ARG A 360
GLY A 359
None
0.74A 2du8A-2nq5A:
undetectable
2du8A-2nq5A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 6 LEU A 311
ILE A 313
ARG A 360
GLY A 359
None
0.75A 2du8B-2nq5A:
undetectable
2du8B-2nq5A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 12 ILE A 643
ALA A 645
ALA A 610
LEU A 607
ILE A 545
None
1.10A 2h79A-2nq5A:
undetectable
2h79A-2nq5A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 6 ASP A 478
VAL A 477
PRO A 509
THR A 492
None
1.22A 2q6oB-2nq5A:
undetectable
2q6oB-2nq5A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
3 / 3 GLN A 197
THR A 159
TRP A 111
None
1.18A 2rctA-2nq5A:
undetectable
2rctA-2nq5A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 5 VAL A 693
VAL A 694
THR A 417
THR A 689
None
1.17A 3bjwA-2nq5A:
undetectable
3bjwA-2nq5A:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 5 VAL A 693
VAL A 694
THR A 417
THR A 689
None
1.10A 3bjwG-2nq5A:
1.2
3bjwG-2nq5A:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 5 VAL A 693
VAL A 694
THR A 417
THR A 689
None
1.14A 3bjwC-2nq5A:
undetectable
3bjwC-2nq5A:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 5 VAL A 693
VAL A 694
THR A 417
THR A 689
None
1.19A 3bjwD-2nq5A:
undetectable
3bjwD-2nq5A:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 5 LEU A 577
ILE A 521
ILE A 574
GLY A 539
None
0.89A 3bufA-2nq5A:
undetectable
3bufA-2nq5A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 7 ILE A 640
LYS A 673
ILE A 651
TYR A 633
None
1.15A 3eteD-2nq5A:
undetectable
3eteF-2nq5A:
undetectable
3eteD-2nq5A:
22.43
3eteF-2nq5A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 4 ILE A 304
PHE A 258
ILE A 269
THR A 297
None
1.05A 3ia4A-2nq5A:
undetectable
3ia4A-2nq5A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 7 GLU A 200
TYR A 181
PHE A 222
TYR A 219
None
1.26A 3ku9B-2nq5A:
undetectable
3ku9B-2nq5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 5 ILE A 570
ARG A 476
THR A 522
GLU A 473
None
1.23A 3ny4A-2nq5A:
undetectable
3ny4A-2nq5A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 5 ILE A 582
ARG A 476
THR A 522
GLU A 475
None
1.31A 3ny4A-2nq5A:
undetectable
3ny4A-2nq5A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 5 ILE A 585
ARG A 476
THR A 522
GLU A 473
None
1.40A 3ny4A-2nq5A:
undetectable
3ny4A-2nq5A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 12 ILE A 511
ILE A 570
ILE A 547
ILE A 616
ASP A 514
None
1.00A 3uj6A-2nq5A:
undetectable
3uj6A-2nq5A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 10 PHE A 709
ILE A 675
ASP A 714
GLY A 678
ASN A 712
None
1.36A 4eb4D-2nq5A:
undetectable
4eb4D-2nq5A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 6 TRP A 123
ASN A  77
TYR A 160
LEU A 177
None
1.47A 4f8yA-2nq5A:
undetectable
4f8yB-2nq5A:
undetectable
4f8yA-2nq5A:
14.02
4f8yB-2nq5A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 8 VAL A 650
PRO A 416
GLN A 406
ILE A 584
None
0.98A 4iilA-2nq5A:
undetectable
4iilA-2nq5A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 8 SER A  73
LEU A  70
TYR A 160
PRO A  80
None
1.12A 4j7uD-2nq5A:
2.4
4j7uD-2nq5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
3 / 3 ARG A 337
GLU A 329
PHE A 342
None
0.93A 4kszA-2nq5A:
undetectable
4kszA-2nq5A:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L64_A_C2FA802_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
6 / 7 LYS A  19
TRP A 497
TYR A 501
ARG A 504
VAL A 506
TRP A 550
None
0.83A 4l64A-2nq5A:
55.9
4l64A-2nq5A:
43.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L64_A_C2FA802_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
6 / 7 TRP A 497
SER A 500
TYR A 501
ARG A 504
VAL A 506
TRP A 550
None
1.03A 4l64A-2nq5A:
55.9
4l64A-2nq5A:
43.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L65_A_C2FA802_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 9 LYS A  19
TYR A 501
ARG A 504
VAL A 506
TRP A 550
None
0.92A 4l65A-2nq5A:
55.9
4l65A-2nq5A:
43.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L6H_A_MTXA803_1
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 10 ASP A 478
TRP A 497
SER A 500
VAL A 506
PRO A 509
None
0.79A 4l6hA-2nq5A:
55.8
4l6hA-2nq5A:
43.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L6H_A_MTXA803_1
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 10 LYS A  19
ASP A 478
TRP A 497
TYR A 116
VAL A 506
None
1.47A 4l6hA-2nq5A:
55.8
4l6hA-2nq5A:
43.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L6H_A_MTXA803_1
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 10 LYS A  19
ASP A 478
TRP A 497
VAL A 506
PRO A 509
None
0.54A 4l6hA-2nq5A:
55.8
4l6hA-2nq5A:
43.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L6H_A_MTXA803_1
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 10 LYS A  19
TRP A 497
VAL A 506
PRO A 509
TRP A 550
None
0.63A 4l6hA-2nq5A:
55.8
4l6hA-2nq5A:
43.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L6H_A_MTXA803_1
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 10 TRP A 497
SER A 500
VAL A 506
PRO A 509
TRP A 550
None
0.91A 4l6hA-2nq5A:
55.8
4l6hA-2nq5A:
43.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 12 ILE A 643
ALA A 645
ALA A 610
LEU A 607
ILE A 545
None
1.10A 4lnxA-2nq5A:
undetectable
4lnxA-2nq5A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 7 TYR A   9
ASN A 328
GLU A  14
GLU A 345
None
1.16A 4mi4A-2nq5A:
undetectable
4mi4C-2nq5A:
undetectable
4mi4A-2nq5A:
12.97
4mi4C-2nq5A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
3 / 3 PRO A 700
LEU A 701
GLN A 708
None
0.38A 4pevB-2nq5A:
3.4
4pevB-2nq5A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 8 ARG A  43
TRP A  18
ALA A  39
LEU A  42
None
1.05A 4rkuA-2nq5A:
undetectable
4rkuJ-2nq5A:
undetectable
4rkuA-2nq5A:
21.95
4rkuJ-2nq5A:
4.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 7 LEU A 240
ALA A 215
LEU A 249
ILE A 158
None
0.78A 4ubsA-2nq5A:
undetectable
4ubsA-2nq5A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 7 TYR A 606
ALA A 613
ILE A 547
LEU A 562
None
1.15A 4uymB-2nq5A:
undetectable
4uymB-2nq5A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
3 / 3 ALA A 505
TRP A 497
VAL A 498
None
0.31A 4w9nC-2nq5A:
undetectable
4w9nC-2nq5A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 7 ARG A  43
TRP A  18
ALA A  39
LEU A  42
None
1.09A 4xk8A-2nq5A:
undetectable
4xk8A-2nq5A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 7 SER A   5
ASP A 257
GLY A 286
THR A 114
None
0.87A 5btaA-2nq5A:
undetectable
5btaC-2nq5A:
undetectable
5btaD-2nq5A:
undetectable
5btaA-2nq5A:
22.94
5btaC-2nq5A:
22.94
5btaD-2nq5A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 7 SER A   5
ASP A 257
GLY A 286
THR A 114
None
0.89A 5btfA-2nq5A:
undetectable
5btfB-2nq5A:
undetectable
5btfC-2nq5A:
undetectable
5btfA-2nq5A:
22.94
5btfB-2nq5A:
16.49
5btfC-2nq5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 6 ALA A 735
THR A 736
VAL A 739
VAL A 679
None
1.00A 5eckA-2nq5A:
undetectable
5eckA-2nq5A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 6 ALA A 735
THR A 736
VAL A 739
VAL A 679
None
0.90A 5eclD-2nq5A:
undetectable
5eclD-2nq5A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
3 / 3 ASN A 113
ASP A 257
GLY A 261
None
0.63A 5fctB-2nq5A:
undetectable
5fctB-2nq5A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSG_B_NIZB809_1
(CATALASE-PEROXIDASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 9 GLU A 473
VAL A 470
GLY A 716
LEU A 717
THR A 719
None
1.47A 5ksgB-2nq5A:
1.5
5ksgB-2nq5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_A_NIZA809_1
(CATALASE-PEROXIDASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 9 GLU A 473
VAL A 470
GLY A 716
LEU A 717
THR A 719
None
1.49A 5ksnA-2nq5A:
0.7
5ksnA-2nq5A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_B_NIZB809_1
(CATALASE-PEROXIDASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 9 GLU A 473
VAL A 470
GLY A 716
LEU A 717
THR A 719
None
1.48A 5ksnB-2nq5A:
undetectable
5ksnB-2nq5A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KT8_B_NIZB809_1
(CATALASE-PEROXIDASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 9 GLU A 473
VAL A 470
GLY A 716
LEU A 717
THR A 719
None
1.45A 5kt8B-2nq5A:
undetectable
5kt8B-2nq5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 8 GLU A 473
VAL A 470
GLY A 716
LEU A 717
THR A 719
None
1.50A 5sxqA-2nq5A:
undetectable
5sxqA-2nq5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXS_B_NIZB806_1
(CATALASE-PEROXIDASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 9 GLU A 473
VAL A 470
GLY A 716
LEU A 717
THR A 719
None
1.48A 5sxsB-2nq5A:
undetectable
5sxsB-2nq5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 8 GLU A 473
VAL A 470
GLY A 716
LEU A 717
THR A 719
None
1.46A 5sxtA-2nq5A:
undetectable
5sxtA-2nq5A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 8 GLU A 473
VAL A 470
GLY A 716
LEU A 717
THR A 719
None
1.46A 5sxtB-2nq5A:
undetectable
5sxtB-2nq5A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_B_NIZB805_1
(CATALASE-PEROXIDASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 9 GLU A 473
VAL A 470
GLY A 716
LEU A 717
THR A 719
None
1.45A 5syiB-2nq5A:
undetectable
5syiB-2nq5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 8 GLU A 473
VAL A 470
GLY A 716
LEU A 717
THR A 719
None
1.46A 5syjB-2nq5A:
undetectable
5syjB-2nq5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 7 SER A 124
ALA A  84
ILE A  88
LEU A  92
None
0.80A 5te8C-2nq5A:
undetectable
5te8C-2nq5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAH_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 12 GLN A 213
LEU A 212
VAL A 251
PRO A 157
ILE A 158
None
1.23A 5uahC-2nq5A:
undetectable
5uahC-2nq5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
3 / 3 ARG A 143
PHE A  46
LEU A  51
None
0.87A 5veuA-2nq5A:
1.8
5veuA-2nq5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 5 THR A 418
ASN A 712
TRP A 710
LEU A 410
None
1.39A 5vkqA-2nq5A:
2.1
5vkqB-2nq5A:
1.2
5vkqA-2nq5A:
18.69
5vkqB-2nq5A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 5 THR A 418
ASN A 712
TRP A 710
LEU A 410
None
1.43A 5vkqB-2nq5A:
1.4
5vkqC-2nq5A:
1.3
5vkqB-2nq5A:
18.69
5vkqC-2nq5A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 10 PHE A 709
ILE A 675
ASP A 714
GLY A 678
ASN A 712
None
1.36A 5x66D-2nq5A:
undetectable
5x66D-2nq5A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 12 VAL A 198
LEU A 135
LEU A  72
ARG A 134
ILE A  69
None
1.46A 5xprA-2nq5A:
2.4
5xprA-2nq5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDQ_B_NIZB808_1
(CATALASE-PEROXIDASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 9 GLU A 473
VAL A 470
GLY A 716
LEU A 717
THR A 719
None
1.47A 6cdqB-2nq5A:
undetectable
6cdqB-2nq5A:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 8 LEU A 300
LEU A 301
LEU A 256
GLY A 255
None
0.89A 6ce2A-2nq5A:
undetectable
6ce2A-2nq5A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CFQ_B_NIZB809_1
(CATALASE-PEROXIDASE)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
5 / 9 GLU A 473
VAL A 470
GLY A 716
LEU A 717
THR A 719
None
1.47A 6cfqB-2nq5A:
1.5
6cfqB-2nq5A:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans)
4 / 8 LEU A 577
VAL A 587
VAL A 621
LEU A 541
None
0.75A 6czmD-2nq5A:
undetectable
6czmF-2nq5A:
undetectable
6czmD-2nq5A:
19.60
6czmF-2nq5A:
19.60