SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nq9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		3 / 3 GLU A 145
HIS A 182
HIS A 109
 ZN  A 401 ( 2.3A)
ZN  A 403 (-3.5A)
ZN  A 401 (-3.2A)
 0.47A 1oe2A-2nq9A:
undetectable		 1oe2A-2nq9A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		4 / 8 ASP A 135
ILE A 132
ASP A  89
ILE A  92
 None
 0.92A 1p7lD-2nq9A:
undetectable		 1p7lD-2nq9A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		4 / 8 ASP A 135
ILE A 132
ASP A  89
ILE A  92
 None
 0.93A 1p7lC-2nq9A:
undetectable		 1p7lC-2nq9A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		4 / 7 VAL A 168
LEU A 106
ALA A 133
LEU A 134
 None
 0.88A 1pthA-2nq9A:
undetectable		 1pthA-2nq9A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		4 / 7 VAL A 168
LEU A 106
ALA A 133
LEU A 134
 None
 0.88A 1pthB-2nq9A:
undetectable		 1pthB-2nq9A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		4 / 8 ASP A 135
ILE A 132
ASP A  89
ILE A  92
 None
 0.92A 1rg9D-2nq9A:
undetectable		 1rg9D-2nq9A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		4 / 8 ASP A 135
ILE A 132
ASP A  89
ILE A  92
 None
 0.93A 1rg9C-2nq9A:
undetectable		 1rg9C-2nq9A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		5 / 12 ASP A 179
GLU A 145
HIS A 216
ARG A 230
GLU A 261
 ZN  A 402 (-3.2A)
ZN  A 401 ( 2.3A)
ZN  A 402 (-3.1A)
None
ZN  A 402 (-2.5A)
 1.36A 1rnrB-2nq9A:
undetectable		 1rnrB-2nq9A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		4 / 5 PRO A 193
ALA A 194
ASP A 179
ASP A 189
 None
None
ZN  A 402 (-3.2A)
None
 1.14A 2nyuB-2nq9A:
undetectable		 2nyuB-2nq9A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		4 / 8 MET A  95
PHE A  91
ARG A  88
LEU A  76
 None
 1.04A 2o01A-2nq9A:
undetectable		 2o01A-2nq9A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		5 / 12 ILE A   4
GLY A   5
VAL A   8
THR A  27
GLN A  65
 None
 1.04A 3bwcA-2nq9A:
undetectable		 3bwcA-2nq9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		3 / 3 MET A 215
MET A   1
PHE A 209
 None
 1.24A 3gn8A-2nq9A:
undetectable		 3gn8A-2nq9A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		5 / 11 THR A  33
GLU A  99
ALA A 133
ASP A  93
ILE A  92
 None
 1.30A 3id5B-2nq9A:
undetectable		 3id5B-2nq9A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		5 / 11 THR A  33
GLU A  99
ALA A 133
ASP A  93
ILE A  92
 None
 1.31A 3id5F-2nq9A:
undetectable		 3id5F-2nq9A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		4 / 7 PHE A  29
GLY A 214
CYH A  98
PHE A  52
 None
 1.11A 3ko0R-2nq9A:
undetectable
3ko0T-2nq9A:
undetectable		 3ko0R-2nq9A:
16.31
3ko0T-2nq9A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		4 / 7 VAL A 168
PHE A  91
ASN A 131
PHE A 108
 None
 1.02A 4ejjB-2nq9A:
undetectable		 4ejjB-2nq9A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		4 / 8 ASP A 135
ILE A 132
ASP A  89
ILE A  92
 None
 0.85A 4kttB-2nq9A:
undetectable		 4kttB-2nq9A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		4 / 8 ASP A 135
ILE A 132
ASP A  89
ILE A  92
 None
 0.91A 4kttD-2nq9A:
undetectable		 4kttD-2nq9A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		4 / 8 ASP A 135
ILE A 132
ASP A  89
ILE A  92
 None
 0.84A 4ndnD-2nq9A:
undetectable		 4ndnD-2nq9A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		4 / 7 HIS A  69
HIS A 109
HIS A 182
ARG A 230
 ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 403 (-3.5A)
None
 0.98A 4p6sB-2nq9A:
undetectable		 4p6sB-2nq9A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		5 / 12 PHE A 244
ILE A 247
GLY A 214
PHE A 200
THR A 199
 None
 0.86A 5byjA-2nq9A:
undetectable		 5byjA-2nq9A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		4 / 8 ALA A 148
HIS A 109
ASN A 153
HIS A 231
 None
ZN  A 401 (-3.2A)
None
ZN  A 403 (-3.3A)
 1.20A 5db5A-2nq9A:
undetectable
5db5B-2nq9A:
undetectable		 5db5A-2nq9A:
21.89
5db5B-2nq9A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		3 / 3 CYH A  56
LYS A  58
HIS A  60
 None
 1.26A 5js5A-2nq9A:
undetectable		 5js5A-2nq9A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		5 / 12 ILE A 126
GLY A 111
HIS A 109
PHE A  91
ALA A 127
 None
None
ZN  A 401 (-3.2A)
None
None
 1.03A 5n0oA-2nq9A:
undetectable		 5n0oA-2nq9A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		5 / 12 ILE A 126
GLY A 111
HIS A 109
PHE A  91
ALA A 127
 None
None
ZN  A 401 (-3.2A)
None
None
 1.03A 5n0oB-2nq9A:
undetectable		 5n0oB-2nq9A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		5 / 12 ILE A 126
GLY A 111
HIS A 109
PHE A  91
ALA A 127
 None
None
ZN  A 401 (-3.2A)
None
None
 1.02A 5n0rA-2nq9A:
undetectable		 5n0rA-2nq9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		5 / 12 ILE A 126
GLY A 111
HIS A 109
PHE A  91
ALA A 127
 None
None
ZN  A 401 (-3.2A)
None
None
 1.02A 5n0sA-2nq9A:
undetectable		 5n0sA-2nq9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		5 / 12 ILE A 126
GLY A 111
HIS A 109
PHE A  91
ALA A 127
 None
None
ZN  A 401 (-3.2A)
None
None
 1.00A 5n0tA-2nq9A:
undetectable		 5n0tA-2nq9A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		5 / 12 ILE A 126
GLY A 111
HIS A 109
PHE A  91
ALA A 127
 None
None
ZN  A 401 (-3.2A)
None
None
 1.00A 5n0tB-2nq9A:
undetectable		 5n0tB-2nq9A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		5 / 12 ILE A 126
GLY A 111
HIS A 109
PHE A  91
ALA A 127
 None
None
ZN  A 401 (-3.2A)
None
None
 1.02A 5n0wA-2nq9A:
undetectable		 5n0wA-2nq9A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		5 / 12 ILE A 126
GLY A 111
HIS A 109
PHE A  91
ALA A 127
 None
None
ZN  A 401 (-3.2A)
None
None
 1.02A 5n0wB-2nq9A:
undetectable		 5n0wB-2nq9A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		5 / 12 ILE A 126
GLY A 111
HIS A 109
PHE A  91
ALA A 127
 None
None
ZN  A 401 (-3.2A)
None
None
 1.01A 5n0xA-2nq9A:
undetectable		 5n0xA-2nq9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		5 / 12 ILE A 126
GLY A 111
HIS A 109
PHE A  91
ALA A 127
 None
None
ZN  A 401 (-3.2A)
None
None
 1.02A 5n0xB-2nq9A:
undetectable		 5n0xB-2nq9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		5 / 12 ILE A 126
GLY A 111
HIS A 109
PHE A  91
ALA A 127
 None
None
ZN  A 401 (-3.2A)
None
None
 1.03A 5n4iA-2nq9A:
undetectable		 5n4iA-2nq9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		4 / 4 ASP A 179
HIS A 182
HIS A 109
HIS A 216
 ZN  A 402 (-3.2A)
ZN  A 403 (-3.5A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.1A)
 1.04A 5ncdD-2nq9A:
undetectable		 5ncdD-2nq9A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		4 / 6 ASP A 179
HIS A 182
HIS A 109
HIS A 216
 ZN  A 402 (-3.2A)
ZN  A 403 (-3.5A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.1A)
 1.03A 5nelB-2nq9A:
undetectable
5nelC-2nq9A:
undetectable		 5nelB-2nq9A:
21.31
5nelC-2nq9A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		4 / 6 HIS A  69
ASP A 179
HIS A 182
HIS A 216
 ZN  A 401 (-3.3A)
ZN  A 402 (-3.2A)
ZN  A 403 (-3.5A)
ZN  A 402 (-3.1A)
 1.05A 5nelB-2nq9A:
undetectable
5nelC-2nq9A:
undetectable		 5nelB-2nq9A:
21.31
5nelC-2nq9A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		4 / 8 ASP A 135
ILE A 132
ASP A  89
ILE A  92
 None
 0.85A 5t8sA-2nq9A:
undetectable		 5t8sA-2nq9A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		5 / 11 HIS A 109
HIS A 231
ASN A 218
HIS A 182
HIS A 216
 ZN  A 401 (-3.2A)
ZN  A 403 (-3.3A)
ZN  A 402 ( 4.9A)
ZN  A 403 (-3.5A)
ZN  A 402 (-3.1A)
 1.10A 5z0gA-2nq9A:
undetectable
5z0gB-2nq9A:
undetectable		 5z0gA-2nq9A:
14.44
5z0gB-2nq9A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		3 / 3 ARG A 227
LYS A 157
TYR A 188
 None
 0.77A 6gnaA-2nq9A:
undetectable		 6gnaA-2nq9A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2nq9 ENDONUCLEASE 4
(Escherichia
coli) 		3 / 3 ARG A 227
LYS A 157
TYR A 188
 None
 0.77A 6gnbA-2nq9A:
undetectable		 6gnbA-2nq9A:
22.53