SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nqn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA
(Escherichia
coli) 		4 / 8 LEU A 265
LEU A 316
PHE A 284
SER A 250
 None
 1.04A 1wrlC-2nqnA:
undetectable
1wrlD-2nqnA:
undetectable		 1wrlC-2nqnA:
10.28
1wrlD-2nqnA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA
(Escherichia
coli) 		4 / 8 VAL A 246
ASP A 241
THR A  22
LEU A 315
 None
 0.98A 1z2bB-2nqnA:
2.1		 1z2bB-2nqnA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA
(Escherichia
coli) 		5 / 12 PHE A 286
GLY A 296
CYH A 295
LEU A 316
LEU A 289
 None
 1.43A 1zgyA-2nqnA:
undetectable		 1zgyA-2nqnA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA
(Escherichia
coli) 		5 / 12 LEU A  18
VAL A 246
ALA A 285
CYH A 295
VAL A 312
 None
 1.33A 2g70A-2nqnA:
undetectable		 2g70A-2nqnA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA
(Escherichia
coli) 		5 / 12 LEU A  18
VAL A 246
ALA A 285
CYH A 295
VAL A 312
 None
 1.32A 2g70B-2nqnA:
undetectable		 2g70B-2nqnA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA
(Escherichia
coli) 		5 / 12 LEU A  18
VAL A 246
ALA A 285
CYH A 295
VAL A 312
 None
 1.34A 2g72A-2nqnA:
undetectable		 2g72A-2nqnA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA
(Escherichia
coli) 		4 / 7 THR A 157
ALA A 317
ASN A 322
LEU A 216
 None
 1.18A 2hzqA-2nqnA:
undetectable		 2hzqA-2nqnA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA
(Escherichia
coli) 		3 / 3 LEU A 161
PRO A 162
ARG A 155
 None
 0.63A 2qd5A-2nqnA:
5.0		 2qd5A-2nqnA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA
(Escherichia
coli) 		4 / 6 ILE A  68
ARG A  64
LEU A  65
LEU A  74
 None
 1.04A 2rlfA-2nqnA:
undetectable
2rlfD-2nqnA:
undetectable		 2rlfA-2nqnA:
7.09
2rlfD-2nqnA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA
(Escherichia
coli) 		5 / 9 LEU A 233
ILE A 221
GLU A 239
PHE A 294
VAL A 247
 None
 1.32A 3tmzA-2nqnA:
undetectable		 3tmzA-2nqnA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA
(Escherichia
coli) 		4 / 5 LEU A  10
LEU A 276
MET A  17
THR A 307
 None
 1.34A 4do3A-2nqnA:
1.9		 4do3A-2nqnA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA
(Escherichia
coli) 		4 / 7 GLY A 251
THR A 185
LEU A 265
PHE A 237
 None
GOL  A 523 ( 4.7A)
None
None
 0.81A 4ejjD-2nqnA:
undetectable		 4ejjD-2nqnA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA
(Escherichia
coli) 		3 / 3 ASP A 245
VAL A  21
LEU A 315
 None
 0.65A 5e5jB-2nqnA:
undetectable		 5e5jB-2nqnA:
13.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA
(Escherichia
coli) 		3 / 3 LYS A 279
SER A 303
SER A 371
 None
 0.58A 6gbfA-2nqnA:
36.0		 6gbfA-2nqnA:
33.40