SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nr4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2nr4 CONSERVED
HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		4 / 4 ALA A 191
VAL A 162
ALA A 161
HIS A 186
 None
 1.21A 1q23K-2nr4A:
undetectable		 1q23K-2nr4A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2nr4 CONSERVED
HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		5 / 7 LEU A 112
GLY A  47
ILE A  48
VAL A  80
ILE A  33
 None
FMN  A 401 (-3.6A)
None
None
None
 1.49A 2aojB-2nr4A:
1.2		 2aojB-2nr4A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2nr4 CONSERVED
HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		4 / 6 LEU A  85
PHE A  86
LEU A  94
PHE A  99
 None
 1.05A 2einP-2nr4A:
2.4
2einW-2nr4A:
undetectable		 2einP-2nr4A:
22.61
2einW-2nr4A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 2nr4 CONSERVED
HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		4 / 8 TRP A 118
GLY A  47
SER A  30
ILE A  32
 None
FMN  A 401 (-3.6A)
None
None
 0.89A 3ihzB-2nr4A:
undetectable		 3ihzB-2nr4A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 2nr4 CONSERVED
HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		3 / 3 THR A 129
SER A 132
ARG A  58
 None
 0.71A 3phnA-2nr4A:
undetectable		 3phnA-2nr4A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2nr4 CONSERVED
HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		4 / 8 ASN A  42
ALA A  43
LEU A 112
LEU A  94
 FMN  A 401 (-2.8A)
None
None
None
 0.98A 4jjkA-2nr4A:
undetectable		 4jjkA-2nr4A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2nr4 CONSERVED
HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		5 / 9 VAL A 102
GLY A 143
ALA A 117
ILE A  32
VAL A 111
 None
 0.94A 4r21B-2nr4A:
undetectable		 4r21B-2nr4A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2nr4 CONSERVED
HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		4 / 5 LEU A  85
PHE A  86
LEU A  94
PHE A  99
 None
 1.13A 5iy5P-2nr4A:
2.4
5iy5W-2nr4A:
undetectable		 5iy5P-2nr4A:
22.61
5iy5W-2nr4A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2nr4 CONSERVED
HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		4 / 5 LEU A  85
PHE A  86
LEU A  94
PHE A  99
 None
 1.16A 5x1fC-2nr4A:
2.4
5x1fJ-2nr4A:
undetectable		 5x1fC-2nr4A:
22.61
5x1fJ-2nr4A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2nr4 CONSERVED
HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		4 / 5 LEU A  85
PHE A  86
LEU A  94
PHE A  99
 None
 1.15A 5xdxC-2nr4A:
2.4
5xdxJ-2nr4A:
undetectable		 5xdxC-2nr4A:
22.61
5xdxJ-2nr4A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2nr4 CONSERVED
HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		4 / 5 LEU A  85
PHE A  86
LEU A  94
PHE A  99
 None
 1.14A 5xdxP-2nr4A:
2.4
5xdxW-2nr4A:
undetectable		 5xdxP-2nr4A:
22.61
5xdxW-2nr4A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 2nr4 CONSERVED
HYPOTHETICAL PROTEIN
(Methanosarcina
mazei) 		4 / 6 ILE A  33
LEU A  94
ARG A  88
SER A  89
 None
 1.06A 6f6jA-2nr4A:
undetectable		 6f6jA-2nr4A:
undetectable