SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nrj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 2nrj HBL B PROTEIN
(Bacillus
cereus) 		5 / 12 LEU A 189
LEU A 235
LEU A 238
MET A  42
GLY A 212
 None
 1.23A 1g50B-2nrjA:
2.3		 1g50B-2nrjA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 2nrj HBL B PROTEIN
(Bacillus
cereus) 		5 / 11 LEU A 189
LEU A 235
LEU A 238
MET A  42
GLY A 212
 None
 1.24A 1g50C-2nrjA:
undetectable		 1g50C-2nrjA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 2nrj HBL B PROTEIN
(Bacillus
cereus) 		4 / 6 THR A 341
GLY A 222
LYS A  45
TYR A  41
 None
 1.18A 1gtiC-2nrjA:
undetectable		 1gtiC-2nrjA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 2nrj HBL B PROTEIN
(Bacillus
cereus) 		4 / 8 ARG A 184
LEU A 238
VAL A 254
GLY A 253
 None
 0.92A 1hrkA-2nrjA:
undetectable		 1hrkA-2nrjA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 2nrj HBL B PROTEIN
(Bacillus
cereus) 		4 / 8 ARG A 184
LEU A 238
VAL A 254
GLY A 253
 None
 0.92A 1hrkB-2nrjA:
undetectable		 1hrkB-2nrjA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2nrj HBL B PROTEIN
(Bacillus
cereus) 		3 / 3 PHE A  32
LEU A 146
LEU A 142
 None
 0.60A 1mx1E-2nrjA:
undetectable		 1mx1E-2nrjA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2nrj HBL B PROTEIN
(Bacillus
cereus) 		3 / 3 ARG A 250
VAL A 223
GLY A 229
 None
 0.65A 2avvE-2nrjA:
undetectable		 2avvE-2nrjA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 2nrj HBL B PROTEIN
(Bacillus
cereus) 		4 / 5 TYR A 287
ILE A 125
LEU A 309
LEU A 313
 None
 1.15A 2zb7A-2nrjA:
undetectable		 2zb7A-2nrjA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2nrj HBL B PROTEIN
(Bacillus
cereus) 		4 / 6 ILE A 259
ILE A 270
LEU A  43
MET A  36
 None
 0.95A 3adsA-2nrjA:
undetectable		 3adsA-2nrjA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2nrj HBL B PROTEIN
(Bacillus
cereus) 		4 / 7 ILE A 259
ILE A 270
LEU A  43
MET A  36
 None
 0.98A 3adxA-2nrjA:
undetectable		 3adxA-2nrjA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 2nrj HBL B PROTEIN
(Bacillus
cereus) 		4 / 7 VAL A 254
ASP A 181
ILE A 220
ASN A  46
 None
 1.05A 3avpA-2nrjA:
undetectable		 3avpA-2nrjA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2nrj HBL B PROTEIN
(Bacillus
cereus) 		4 / 8 GLU A 261
ASN A 258
ASN A 260
ILE A 153
 None
 1.28A 3kp6A-2nrjA:
0.9
3kp6B-2nrjA:
undetectable		 3kp6A-2nrjA:
19.58
3kp6B-2nrjA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2nrj HBL B PROTEIN
(Bacillus
cereus) 		4 / 6 ASN A 260
ILE A 153
GLU A 261
ASN A 258
 None
 1.33A 3kp6A-2nrjA:
0.9
3kp6B-2nrjA:
0.5		 3kp6A-2nrjA:
19.58
3kp6B-2nrjA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 2nrj HBL B PROTEIN
(Bacillus
cereus) 		4 / 7 ILE A 125
LYS A 307
PHE A 306
GLY A 116
 None
 0.83A 3sj0X-2nrjA:
undetectable		 3sj0X-2nrjA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 2nrj HBL B PROTEIN
(Bacillus
cereus) 		4 / 6 ILE A 170
LEU A 167
PHE A  51
GLY A  64
 None
 1.02A 3sj1X-2nrjA:
undetectable		 3sj1X-2nrjA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 2nrj HBL B PROTEIN
(Bacillus
cereus) 		4 / 7 ILE A 125
LYS A 307
PHE A 306
GLY A 116
 None
 0.82A 4hajA-2nrjA:
undetectable		 4hajA-2nrjA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2nrj HBL B PROTEIN
(Bacillus
cereus) 		4 / 8 ILE A 125
LYS A 307
PHE A 306
GLY A 116
 None
 0.84A 4hb6A-2nrjA:
undetectable		 4hb6A-2nrjA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 2nrj HBL B PROTEIN
(Bacillus
cereus) 		5 / 12 MET A  22
LEU A 330
ALA A 327
LEU A  88
LEU A 142
 None
 1.17A 4j24D-2nrjA:
undetectable		 4j24D-2nrjA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2nrj HBL B PROTEIN
(Bacillus
cereus) 		4 / 4 ASP A 326
LEU A  26
ARG A  21
THR A 322
 None
 1.39A 4kjjA-2nrjA:
undetectable		 4kjjA-2nrjA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2nrj HBL B PROTEIN
(Bacillus
cereus) 		4 / 4 ASP A 326
LEU A  26
ARG A  21
THR A 322
 None
 1.44A 4kjkA-2nrjA:
undetectable		 4kjkA-2nrjA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2nrj HBL B PROTEIN
(Bacillus
cereus) 		3 / 3 ALA A 269
GLN A  27
GLY A 202
 None
 0.64A 4odoC-2nrjA:
undetectable		 4odoC-2nrjA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2nrj HBL B PROTEIN
(Bacillus
cereus) 		5 / 9 ILE A 220
VAL A 221
GLY A 218
THR A 247
VAL A 254
 None
 1.25A 4r20B-2nrjA:
0.9		 4r20B-2nrjA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2nrj HBL B PROTEIN
(Bacillus
cereus) 		4 / 7 THR A  91
LEU A  92
LEU A  88
THR A  25
 None
 0.80A 4z90A-2nrjA:
3.6
4z90B-2nrjA:
3.9
4z90C-2nrjA:
3.6
4z90D-2nrjA:
3.5
4z90E-2nrjA:
3.5		 4z90A-2nrjA:
23.33
4z90B-2nrjA:
23.33
4z90C-2nrjA:
23.33
4z90D-2nrjA:
23.33
4z90E-2nrjA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2nrj HBL B PROTEIN
(Bacillus
cereus) 		4 / 8 LEU A  88
THR A  25
THR A  91
LEU A  92
 None
 0.78A 4z90F-2nrjA:
3.6
4z90G-2nrjA:
3.5
4z90H-2nrjA:
3.5
4z90I-2nrjA:
3.5
4z90J-2nrjA:
3.6		 4z90F-2nrjA:
23.33
4z90G-2nrjA:
23.33
4z90H-2nrjA:
23.33
4z90I-2nrjA:
23.33
4z90J-2nrjA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_2
(CALCINEURIN SUBUNIT
B, VARIANT
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2nrj HBL B PROTEIN
(Bacillus
cereus) 		4 / 4 LEU A  31
MET A 206
VAL A 205
ASN A 204
 None
 1.41A 5b8iB-2nrjA:
0.4		 5b8iB-2nrjA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2nrj HBL B PROTEIN
(Bacillus
cereus) 		3 / 3 ASP A 326
LEU A  26
ARG A  21
 None
 0.82A 7dfrA-2nrjA:
undetectable		 7dfrA-2nrjA:
17.94