SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nrk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 2nrk HYPOTHETICAL PROTEIN
GRPB
(Enterococcus
faecalis) 		4 / 6 LEU A  89
TYR A  77
ILE A  26
ILE A 102
 None
 0.95A 2q8hA-2nrkA:
undetectable		 2q8hA-2nrkA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 2nrk HYPOTHETICAL PROTEIN
GRPB
(Enterococcus
faecalis) 		4 / 7 LYS A 135
TYR A 131
LYS A 158
GLU A 161
 None
 1.28A 3hs4A-2nrkA:
undetectable		 3hs4A-2nrkA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)		 2nrk HYPOTHETICAL PROTEIN
GRPB
(Enterococcus
faecalis) 		4 / 5 ASP A  64
GLU A  80
GLY A  79
GLN A  67
 None
 1.29A 3w9tB-2nrkA:
undetectable		 3w9tB-2nrkA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 2nrk HYPOTHETICAL PROTEIN
GRPB
(Enterococcus
faecalis) 		4 / 5 ASP A  64
GLU A  80
GLY A  79
GLN A  67
 None
 1.28A 3w9tD-2nrkA:
undetectable		 3w9tD-2nrkA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 2nrk HYPOTHETICAL PROTEIN
GRPB
(Enterococcus
faecalis) 		4 / 5 ASP A  64
GLU A  80
GLY A  79
GLN A  67
 None
 1.23A 3w9tE-2nrkA:
undetectable		 3w9tE-2nrkA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 2nrk HYPOTHETICAL PROTEIN
GRPB
(Enterococcus
faecalis) 		4 / 5 ASP A  64
GLU A  80
GLY A  79
GLN A  67
 None
 1.15A 3w9tG-2nrkA:
undetectable		 3w9tG-2nrkA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2nrk HYPOTHETICAL PROTEIN
GRPB
(Enterococcus
faecalis) 		3 / 3 TYR A  88
HIS A 101
ARG A  86
 None
 1.00A 4e7bC-2nrkA:
undetectable		 4e7bC-2nrkA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2nrk HYPOTHETICAL PROTEIN
GRPB
(Enterococcus
faecalis) 		3 / 3 HIS A 101
GLY A  38
ILE A  37
 None
 0.59A 4k50A-2nrkA:
undetectable		 4k50A-2nrkA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2nrk HYPOTHETICAL PROTEIN
GRPB
(Enterococcus
faecalis) 		3 / 3 HIS A 101
GLY A  38
ILE A  37
 None
 0.59A 4k50I-2nrkA:
undetectable		 4k50I-2nrkA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 2nrk HYPOTHETICAL PROTEIN
GRPB
(Enterococcus
faecalis) 		4 / 8 GLY A  85
TYR A 103
ASN A 107
ARG A  86
 None
 1.13A 4m5mA-2nrkA:
undetectable		 4m5mA-2nrkA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 2nrk HYPOTHETICAL PROTEIN
GRPB
(Enterococcus
faecalis) 		5 / 11 GLY A  38
SER A  41
LEU A  45
ALA A 128
PHE A 117
 None
 1.50A 6qgbA-2nrkA:
undetectable		 6qgbA-2nrkA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_F_BEZF701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 2nrk HYPOTHETICAL PROTEIN
GRPB
(Enterococcus
faecalis) 		5 / 10 GLY A  38
SER A  41
LEU A  45
ALA A 128
PHE A 117
 None
 1.50A 6qgbF-2nrkA:
undetectable		 6qgbF-2nrkA:
13.80