SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nrr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2nrr UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		5 / 12 ILE A 483
GLN A 482
THR A 487
LEU A 477
LEU A 454
 None
 0.97A 1rjdA-2nrrA:
undetectable		 1rjdA-2nrrA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2nrr UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		5 / 12 ILE A 483
GLN A 482
THR A 487
LEU A 477
LEU A 454
 None
 0.97A 1rjdB-2nrrA:
undetectable		 1rjdB-2nrrA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2nrr UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		5 / 12 ILE A 483
GLN A 482
THR A 487
LEU A 477
LEU A 454
 None
 0.96A 1rjdC-2nrrA:
undetectable		 1rjdC-2nrrA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 2nrr UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		3 / 3 LEU A 371
HIS A 370
LYS A 375
 None
 1.12A 1y7iA-2nrrA:
undetectable		 1y7iA-2nrrA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 2nrr UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		4 / 8 THR A 376
VAL A 412
THR A 411
ASP A 405
 None
 0.97A 2qbmA-2nrrA:
undetectable		 2qbmA-2nrrA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 2nrr UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		4 / 5 LEU A 479
ASP A 485
LEU A 354
HIS A 474
 None
 0.97A 2qxsA-2nrrA:
undetectable		 2qxsA-2nrrA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 2nrr UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		4 / 5 LEU A 479
ASP A 485
LEU A 354
HIS A 474
 None
 0.94A 2qxsB-2nrrA:
undetectable		 2qxsB-2nrrA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2nrr UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		4 / 5 LEU A 426
GLY A 365
THR A 487
ILE A 368
 None
 0.87A 3wriA-2nrrA:
undetectable		 3wriA-2nrrA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2nrr UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		4 / 5 LEU A 426
GLY A 365
THR A 487
ILE A 368
 None
 0.86A 3wriB-2nrrA:
undetectable		 3wriB-2nrrA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2nrr UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		3 / 3 LYS A 419
LEU A 422
ILE A 445
 None
 0.69A 5kc0A-2nrrA:
undetectable		 5kc0A-2nrrA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2nrr UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		3 / 3 LYS A 419
LEU A 422
ILE A 445
 None
 0.77A 5kc4A-2nrrA:
undetectable		 5kc4A-2nrrA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 2nrr UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		5 / 10 LEU A 380
ILE A 363
LEU A 425
ALA A 438
LEU A 442
 None
 1.24A 5y7pB-2nrrA:
undetectable		 5y7pB-2nrrA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 2nrr UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		5 / 10 LEU A 380
ILE A 363
LEU A 425
ALA A 438
LEU A 442
 None
 1.23A 5y7pH-2nrrA:
undetectable		 5y7pH-2nrrA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 2nrr UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		4 / 7 VAL A 461
VAL A 452
ILE A 483
PHE A 427
 None
 0.80A 5ywmX-2nrrA:
undetectable		 5ywmX-2nrrA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2nrr UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		5 / 10 ALA A 455
VAL A 462
VAL A 428
ILE A 439
ALA A 438
 None
 1.08A 6h1lA-2nrrA:
undetectable		 6h1lA-2nrrA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2nrr UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		5 / 11 ALA A 455
VAL A 462
VAL A 428
ILE A 439
ALA A 438
 None
 1.15A 6h1lB-2nrrA:
undetectable		 6h1lB-2nrrA:
17.32