SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nrx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 2nrx UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		5 / 12 LEU A 426
LEU A 425
ALA A 438
ILE A 409
ILE A 483
 None
 1.14A 1tw4A-2nrxA:
undetectable		 1tw4A-2nrxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 2nrx UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		4 / 8 THR A 376
VAL A 412
THR A 411
ASP A 405
 None
 0.96A 2qbmA-2nrxA:
undetectable		 2qbmA-2nrxA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 2nrx UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		5 / 9 LEU A 480
LEU A 350
ILE A 439
PHE A 427
VAL A 428
 None
 1.32A 3tmzA-2nrxA:
undetectable		 3tmzA-2nrxA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		 2nrx UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		5 / 10 LEU A 479
ARG A 489
PRO A 388
GLU A 486
PHE A 383
 None
 1.43A 3ua5B-2nrxA:
0.0		 3ua5B-2nrxA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2nrx UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		4 / 5 LEU A 426
GLY A 365
THR A 487
ILE A 368
 None
 0.82A 3wriA-2nrxA:
undetectable		 3wriA-2nrxA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2nrx UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		4 / 5 LEU A 426
GLY A 365
THR A 487
ILE A 368
 None
 0.82A 3wriB-2nrxA:
undetectable		 3wriB-2nrxA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 2nrx UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		5 / 11 PHE A 427
GLY A 365
ALA A 455
GLY A 431
GLU A 458
 None
None
None
SO4  A 903 (-3.5A)
None
 0.91A 4a6nA-2nrxA:
undetectable		 4a6nA-2nrxA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2nrx UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		4 / 7 GLU A 548
GLY A 515
ARG A 518
LYS A 519
 None
SO4  A 901 (-3.4A)
None
None
 0.94A 4fgzA-2nrxA:
undetectable		 4fgzA-2nrxA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2nrx UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		4 / 8 GLU A 548
GLY A 515
ARG A 518
LYS A 519
 None
SO4  A 901 (-3.4A)
None
None
 0.94A 4fgzA-2nrxA:
undetectable
4fgzB-2nrxA:
undetectable		 4fgzA-2nrxA:
19.27
4fgzB-2nrxA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 2nrx UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		3 / 3 ARG A 478
ASP A 485
ASP A 429
 None
 0.74A 4kicB-2nrxA:
undetectable		 4kicB-2nrxA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2nrx UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		3 / 3 HIS A 469
VAL A 481
LEU A 454
 None
 0.74A 4m2vA-2nrxA:
undetectable		 4m2vA-2nrxA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 2nrx UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		3 / 3 LYS A 497
ARG A 498
HIS A 495
 None
 1.20A 4zbrA-2nrxA:
2.5		 4zbrA-2nrxA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 2nrx UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		5 / 12 ASP A 405
SER A 379
HIS A 495
LEU A 371
TYR A 375
 None
 1.48A 5ef8B-2nrxA:
undetectable		 5ef8B-2nrxA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 2nrx UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		5 / 12 GLY A 453
ILE A 483
ILE A 432
ASN A 436
LEU A 353
 None
 1.17A 5fa8A-2nrxA:
undetectable		 5fa8A-2nrxA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 2nrx UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		5 / 10 LEU A 380
ILE A 363
LEU A 425
ALA A 438
LEU A 442
 None
 1.25A 5y7pB-2nrxA:
undetectable		 5y7pB-2nrxA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 2nrx UVRABC SYSTEM
PROTEIN C
(Thermotoga
maritima) 		5 / 10 LEU A 380
ILE A 363
LEU A 425
ALA A 438
LEU A 442
 None
 1.25A 5y7pH-2nrxA:
undetectable		 5y7pH-2nrxA:
21.41