SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nsa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2nsa TRIGGER FACTOR
(Thermotoga
maritima) 		4 / 6 ALA A 391
LEU A 384
GLU A 359
LEU A 363
 SO4  A 415 (-3.8A)
None
SO4  A 415 (-3.0A)
None
 0.84A 1mt1D-2nsaA:
undetectable
1mt1E-2nsaA:
undetectable		 1mt1D-2nsaA:
22.22
1mt1E-2nsaA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2nsa TRIGGER FACTOR
(Thermotoga
maritima) 		4 / 6 LEU A 384
VAL A 397
ILE A 392
ARG A 338
 None
None
SO4  A 415 (-4.7A)
None
 1.12A 1opjB-2nsaA:
undetectable		 1opjB-2nsaA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nsa TRIGGER FACTOR
(Thermotoga
maritima) 		3 / 3 GLU A 266
GLU A 273
LEU A 255
 None
 0.75A 1v8bA-2nsaA:
undetectable		 1v8bA-2nsaA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 2nsa TRIGGER FACTOR
(Thermotoga
maritima) 		4 / 5 LEU A 251
GLU A 277
MET A 271
LEU A 402
 None
 1.29A 4xi3B-2nsaA:
undetectable		 4xi3B-2nsaA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 2nsa TRIGGER FACTOR
(Thermotoga
maritima) 		4 / 5 PRO A 371
ALA A 374
ALA A 364
ILE A 369
 None
 0.73A 5jncD-2nsaA:
undetectable		 5jncD-2nsaA:
22.68