SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nsm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		5 / 11 GLU A 303
GLY A 198
GLU A 288
LEU A  75
GLU A  69
 None
None
SO4  A1776 ( 4.7A)
None
SO4  A1776 ( 4.6A)
 1.16A 1i7qA-2nsmA:
undetectable		 1i7qA-2nsmA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		5 / 10 GLU A 377
ALA A 337
LEU A 334
ALA A 371
GLY A 373
 None
 1.31A 1mjqG-2nsmA:
undetectable
1mjqH-2nsmA:
undetectable		 1mjqG-2nsmA:
12.12
1mjqH-2nsmA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		5 / 12 VAL A  59
ALA A 193
LEU A 195
LEU A 311
LEU A  83
 None
 1.08A 1qzfA-2nsmA:
undetectable		 1qzfA-2nsmA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		5 / 12 VAL A  59
ALA A 193
LEU A 195
LEU A 311
LEU A  83
 None
 1.09A 1qzfB-2nsmA:
undetectable		 1qzfB-2nsmA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		5 / 12 VAL A  59
ALA A 193
LEU A 195
LEU A 311
LEU A  83
 None
 1.09A 1qzfC-2nsmA:
undetectable		 1qzfC-2nsmA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		5 / 12 VAL A  59
ALA A 193
LEU A 195
LEU A 311
LEU A  83
 None
 1.09A 1qzfD-2nsmA:
undetectable		 1qzfD-2nsmA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		5 / 12 VAL A  59
ALA A 193
LEU A 195
LEU A 311
LEU A  83
 None
 1.10A 1qzfE-2nsmA:
undetectable		 1qzfE-2nsmA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		3 / 3 GLU A 288
ASN A 203
TRP A 265
 SO4  A1776 ( 4.7A)
None
None
 1.30A 1r15D-2nsmA:
undetectable		 1r15D-2nsmA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		3 / 3 GLU A 288
ASN A 203
TRP A 265
 SO4  A1776 ( 4.7A)
None
None
 1.29A 1r15E-2nsmA:
undetectable		 1r15E-2nsmA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		5 / 12 GLY A 198
GLY A 197
LEU A 195
GLY A  72
ARG A  73
 None
 1.22A 1y4lA-2nsmA:
undetectable		 1y4lA-2nsmA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		5 / 9 GLU A 115
LEU A   1
ARG A   4
LEU A  77
ALA A  70
 None
SO4  A 776 (-3.7A)
SO4  A 776 (-3.8A)
None
None
 1.06A 2bxcB-2nsmA:
undetectable		 2bxcB-2nsmA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		4 / 8 TYR A 127
GLU A  69
HIS A 196
GLY A 197
 None
SO4  A1776 ( 4.6A)
SO4  A1776 (-3.9A)
None
 0.97A 2ha4A-2nsmA:
2.6		 2ha4A-2nsmA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		4 / 7 TYR A 127
GLU A  69
HIS A 196
GLY A 197
 None
SO4  A1776 ( 4.6A)
SO4  A1776 (-3.9A)
None
 0.97A 2ha4B-2nsmA:
3.1		 2ha4B-2nsmA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		5 / 12 VAL A  59
ALA A 193
LEU A 195
LEU A 311
LEU A  83
 None
 1.02A 2oipA-2nsmA:
undetectable		 2oipA-2nsmA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		3 / 3 LEU A 165
PRO A 166
ARG A 178
 None
 0.59A 2qd4B-2nsmA:
undetectable		 2qd4B-2nsmA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		5 / 12 ASN A 110
ASN A  64
ILE A 181
ASN A 194
LEU A 139
 None
 1.01A 3eeyA-2nsmA:
undetectable		 3eeyA-2nsmA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		5 / 12 ASN A 110
ASN A  64
ILE A 181
ASN A 194
LEU A 139
 None
 1.00A 3eeyB-2nsmA:
undetectable		 3eeyB-2nsmA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		5 / 12 VAL A  59
ALA A 193
LEU A 195
LEU A 311
LEU A  83
 None
 1.08A 3hj3D-2nsmA:
undetectable		 3hj3D-2nsmA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		5 / 10 PHE A 357
ALA A 337
ASN A 333
LEU A 334
VAL A 326
 None
 1.24A 3o02A-2nsmA:
undetectable
3o02B-2nsmA:
undetectable		 3o02A-2nsmA:
19.60
3o02B-2nsmA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		5 / 12 LEU A 359
VAL A 190
PHE A 189
THR A 101
TYR A  29
 None
 1.20A 3sp9B-2nsmA:
undetectable		 3sp9B-2nsmA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		5 / 12 PHE A 314
PHE A 283
GLY A 321
LEU A 360
GLN A 320
 None
 1.22A 3tbgA-2nsmA:
undetectable		 3tbgA-2nsmA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		5 / 12 PHE A 314
PHE A 283
GLY A 321
LEU A 360
GLN A 320
 None
 1.24A 3tbgC-2nsmA:
undetectable		 3tbgC-2nsmA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		4 / 6 ILE A 285
TRP A 183
ILE A 181
MET A 272
 None
 1.15A 3weoA-2nsmA:
undetectable		 3weoA-2nsmA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		4 / 5 LEU A 268
GLY A 262
THR A 260
VAL A 201
 SO4  A1776 (-4.9A)
None
None
None
 1.04A 3wrkD-2nsmA:
undetectable		 3wrkD-2nsmA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		4 / 6 GLY A 113
PRO A 111
ASN A 110
GLY A  37
 None
 0.86A 4fjpA-2nsmA:
undetectable		 4fjpA-2nsmA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		5 / 12 VAL A  59
ALA A 193
LEU A 195
LEU A 311
LEU A  83
 None
 1.02A 4ky8A-2nsmA:
undetectable		 4ky8A-2nsmA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		5 / 12 VAL A  59
ALA A 193
LEU A 195
LEU A 311
LEU A  83
 None
 0.98A 4ky8B-2nsmA:
undetectable		 4ky8B-2nsmA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		5 / 12 VAL A  59
ALA A 193
LEU A 195
LEU A 311
LEU A  83
 None
 1.00A 4ky8D-2nsmA:
undetectable		 4ky8D-2nsmA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		5 / 12 VAL A  59
ALA A 193
LEU A 195
LEU A 311
LEU A  83
 None
 0.98A 4ky8E-2nsmA:
undetectable		 4ky8E-2nsmA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		4 / 6 ASN A 110
GLU A  36
GLU A 115
TYR A 114
 None
 1.40A 4mi4A-2nsmA:
undetectable		 4mi4A-2nsmA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		4 / 5 SER A  34
GLY A  37
ARG A  38
GLU A  36
 None
 1.31A 4r82A-2nsmA:
undetectable
4r82B-2nsmA:
undetectable		 4r82A-2nsmA:
18.10
4r82B-2nsmA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		4 / 6 PHE A 393
SER A 350
LEU A 334
LEU A 395
 None
 1.08A 5dzke-2nsmA:
undetectable
5dzks-2nsmA:
undetectable		 5dzke-2nsmA:
18.47
5dzks-2nsmA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		5 / 12 TYR A 238
GLY A  72
LEU A  71
MET A 245
ILE A 259
 None
 1.22A 5fepA-2nsmA:
undetectable		 5fepA-2nsmA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		5 / 12 TYR A 238
GLY A  72
LEU A  71
MET A 245
ILE A 259
 None
 1.20A 5fesA-2nsmA:
undetectable		 5fesA-2nsmA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		4 / 4 ASN A 188
ILE A 285
TYR A 277
PHE A 143
 None
 1.46A 5igvA-2nsmA:
undetectable		 5igvA-2nsmA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		4 / 6 ASP A 138
HIS A  66
TYR A 127
TYR A 266
 SO4  A1776 ( 4.7A)
SO4  A1776 (-4.2A)
None
SO4  A1776 (-4.8A)
 1.24A 5ih0A-2nsmA:
undetectable		 5ih0A-2nsmA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		3 / 3 VAL A 200
SER A 290
TRP A 244
 None
 0.49A 5jwaA-2nsmA:
undetectable		 5jwaA-2nsmA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		5 / 12 ASP A  47
ILE A  98
GLU A  86
ARG A  88
ASN A  89
 None
 1.34A 5k7uA-2nsmA:
undetectable		 5k7uA-2nsmA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		3 / 3 HIS A 104
LYS A  60
PHE A 189
 None
 1.47A 5klaA-2nsmA:
undetectable		 5klaA-2nsmA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		5 / 12 ILE A 339
VAL A 381
SER A 368
ALA A 369
ALA A 337
 None
 1.08A 5n0oB-2nsmA:
undetectable		 5n0oB-2nsmA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		4 / 7 ASP A 274
GLY A 271
ASP A 207
ASN A 276
 None
 1.03A 5nnwD-2nsmA:
undetectable		 5nnwD-2nsmA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		4 / 7 ASP A 274
GLY A 271
ASP A 207
ASN A 276
 None
 0.97A 5no9D-2nsmA:
undetectable		 5no9D-2nsmA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		4 / 5 LEU A 287
LEU A 289
MET A  65
GLN A 273
 None
 1.24A 5uc3A-2nsmA:
undetectable		 5uc3A-2nsmA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		3 / 3 ILE A 103
VAL A  59
PRO A  57
 None
 0.73A 5uunA-2nsmA:
undetectable		 5uunA-2nsmA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens) 		4 / 8 ASN A 194
HIS A  66
ASN A 203
GLU A 288
 None
SO4  A1776 (-4.2A)
None
SO4  A1776 ( 4.7A)
 1.04A 6b94A-2nsmA:
undetectable		 6b94A-2nsmA:
12.06