SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nsq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2nsq E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
PROTEIN
(Homo
sapiens) 		4 / 8 THR A  69
THR A  63
VAL A  93
VAL A  45
 None
 0.79A 1t86A-2nsqA:
undetectable		 1t86A-2nsqA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 2nsq E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
PROTEIN
(Homo
sapiens) 		5 / 11 VAL A  93
GLY A  29
THR A  69
ILE A  66
THR A  63
 None
 1.47A 2f9wA-2nsqA:
undetectable
2f9wB-2nsqA:
undetectable		 2f9wA-2nsqA:
22.14
2f9wB-2nsqA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 2nsq E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ASN A  75
LEU A  32
GLY A  29
ILE A  66
THR A  69
 None
 1.17A 4o5fA-2nsqA:
undetectable
4o5fB-2nsqA:
undetectable		 4o5fA-2nsqA:
18.73
4o5fB-2nsqA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 2nsq E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 THR A  69
ASN A  75
LEU A  32
GLY A  29
ILE A  66
 None
 1.15A 4o5fA-2nsqA:
undetectable
4o5fB-2nsqA:
undetectable		 4o5fA-2nsqA:
18.73
4o5fB-2nsqA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 2nsq E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ASN A  75
LEU A  32
GLY A  29
ILE A  66
THR A  69
 None
 1.15A 5b8hA-2nsqA:
undetectable
5b8hB-2nsqA:
undetectable		 5b8hA-2nsqA:
19.65
5b8hB-2nsqA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 2nsq E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 THR A  69
ASN A  75
LEU A  32
GLY A  29
ILE A  66
 None
 1.18A 5b8hA-2nsqA:
undetectable
5b8hB-2nsqA:
undetectable		 5b8hA-2nsqA:
19.65
5b8hB-2nsqA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nsq E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
PROTEIN
(Homo
sapiens) 		3 / 3 THR A  69
THR A  63
LEU A 146
 None
 0.53A 5m66D-2nsqA:
undetectable		 5m66D-2nsqA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 2nsq E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
PROTEIN
(Homo
sapiens) 		3 / 3 ILE A  66
THR A  65
PRO A  72
 None
 0.64A 6ncsA-2nsqA:
undetectable		 6ncsA-2nsqA:
18.49