SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nt2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nt2 PROTEIN PHOSPHATASE
SLINGSHOT HOMOLOG 2
(Homo
sapiens) 		5 / 12 ALA A 418
TRP A 413
LEU A 439
VAL A 390
ILE A 378
 None
 1.00A 1fm6U-2nt2A:
undetectable		 1fm6U-2nt2A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2nt2 PROTEIN PHOSPHATASE
SLINGSHOT HOMOLOG 2
(Homo
sapiens) 		3 / 3 LYS A 430
ILE A 404
THR A 309
 None
 0.59A 1rx3A-2nt2A:
undetectable		 1rx3A-2nt2A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2nt2 PROTEIN PHOSPHATASE
SLINGSHOT HOMOLOG 2
(Homo
sapiens) 		4 / 6 TYR A 411
TYR A 406
GLY A 412
TYR A 375
 None
 1.25A 2g72A-2nt2A:
undetectable		 2g72A-2nt2A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 2nt2 PROTEIN PHOSPHATASE
SLINGSHOT HOMOLOG 2
(Homo
sapiens) 		4 / 6 LEU A 446
MET A 408
LEU A 415
GLU A 441
 None
 1.30A 2kuhA-2nt2A:
undetectable		 2kuhA-2nt2A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2nt2 PROTEIN PHOSPHATASE
SLINGSHOT HOMOLOG 2
(Homo
sapiens) 		4 / 6 GLU A 362
TYR A 360
SER A 434
GLN A 438
 None
 1.35A 2zvjA-2nt2A:
undetectable		 2zvjA-2nt2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CAS_A_ASDA332_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 2nt2 PROTEIN PHOSPHATASE
SLINGSHOT HOMOLOG 2
(Homo
sapiens) 		5 / 10 THR A 402
SER A 401
VAL A 340
VAL A 390
LEU A 389
 None
 1.46A 3casA-2nt2A:
undetectable		 3casA-2nt2A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 2nt2 PROTEIN PHOSPHATASE
SLINGSHOT HOMOLOG 2
(Homo
sapiens) 		4 / 6 ASP A 416
GLU A 440
LEU A 415
TYR A 419
 None
 1.16A 3w9tB-2nt2A:
undetectable		 3w9tB-2nt2A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 2nt2 PROTEIN PHOSPHATASE
SLINGSHOT HOMOLOG 2
(Homo
sapiens) 		4 / 6 ASP A 416
GLU A 440
LEU A 415
TYR A 419
 None
 1.16A 3w9tE-2nt2A:
undetectable		 3w9tE-2nt2A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 2nt2 PROTEIN PHOSPHATASE
SLINGSHOT HOMOLOG 2
(Homo
sapiens) 		4 / 6 ASP A 416
GLU A 440
LEU A 415
TYR A 419
 None
 1.15A 3w9tF-2nt2A:
undetectable		 3w9tF-2nt2A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2nt2 PROTEIN PHOSPHATASE
SLINGSHOT HOMOLOG 2
(Homo
sapiens) 		3 / 3 LYS A 430
ILE A 404
THR A 309
 None
 0.61A 4gh8A-2nt2A:
undetectable		 4gh8A-2nt2A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)		 2nt2 PROTEIN PHOSPHATASE
SLINGSHOT HOMOLOG 2
(Homo
sapiens) 		4 / 8 ASN A 322
PRO A 308
PHE A 316
TYR A 354
 None
 1.27A 4v30B-2nt2A:
undetectable		 4v30B-2nt2A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_B_EF2B202_0
(CEREBLON ISOFORM 4)		 2nt2 PROTEIN PHOSPHATASE
SLINGSHOT HOMOLOG 2
(Homo
sapiens) 		4 / 7 ASN A 322
PRO A 308
PHE A 316
TYR A 354
 None
 1.30A 5oh1B-2nt2A:
0.0		 5oh1B-2nt2A:
16.54