SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nt4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 2nt4 RESPONSE REGULATOR
HOMOLOG
(Myxococcus
xanthus) 		5 / 12 LEU A  22
LEU A 112
ALA A 116
LEU A 119
ILE A   7
 None
 1.05A 1crbA-2nt4A:
undetectable		 1crbA-2nt4A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2nt4 RESPONSE REGULATOR
HOMOLOG
(Myxococcus
xanthus) 		5 / 12 ILE A   5
ILE A  65
LEU A  69
LEU A  75
VAL A  78
 None
 1.01A 3adsB-2nt4A:
undetectable		 3adsB-2nt4A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 2nt4 RESPONSE REGULATOR
HOMOLOG
(Myxococcus
xanthus) 		5 / 9 ALA A  99
ASP A 100
GLY A  67
VAL A  54
ILE A  82
 None
None
None
CL  A 125 (-4.3A)
None
 1.15A 3em4B-2nt4A:
undetectable		 3em4B-2nt4A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2nt4 RESPONSE REGULATOR
HOMOLOG
(Myxococcus
xanthus) 		4 / 8 VAL A  51
CYH A  66
VAL A   8
ILE A  82
 None
 1.17A 4aftD-2nt4A:
undetectable
4aftE-2nt4A:
undetectable		 4aftD-2nt4A:
21.96
4aftE-2nt4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 2nt4 RESPONSE REGULATOR
HOMOLOG
(Myxococcus
xanthus) 		5 / 8 ALA A  99
ASP A 100
GLY A  67
VAL A  54
ILE A  82
 None
None
None
CL  A 125 (-4.3A)
None
 1.34A 4ll3A-2nt4A:
undetectable		 4ll3A-2nt4A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2nt4 RESPONSE REGULATOR
HOMOLOG
(Myxococcus
xanthus) 		4 / 8 SER A  38
LEU A  69
LEU A  75
VAL A  78
 None
 0.96A 4oj4A-2nt4A:
undetectable		 4oj4A-2nt4A:
21.80