SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ntb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		4 / 8 ILE A  63
LEU A  81
ALA A  48
VAL A  32
 None
 0.77A 1a29A-2ntbA:
undetectable		 1a29A-2ntbA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		5 / 11 SER A 262
VAL A 227
TYR A 301
TYR A 230
GLY A 196
 None
 1.10A 1i9jH-2ntbA:
undetectable
1i9jL-2ntbA:
undetectable		 1i9jH-2ntbA:
21.33
1i9jL-2ntbA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		4 / 7 TRP A 107
LEU A 100
SER A 105
ASP A 103
 None
 1.24A 1ismB-2ntbA:
undetectable		 1ismB-2ntbA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		4 / 4 ILE A 201
LEU A 180
VAL A 159
ALA A 119
 None
 0.87A 1mz9A-2ntbA:
undetectable		 1mz9A-2ntbA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		4 / 5 ILE A 201
LEU A 180
VAL A 159
ALA A 119
 None
 0.88A 1mz9C-2ntbA:
undetectable		 1mz9C-2ntbA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		4 / 5 GLY A 243
GLN A 240
VAL A 182
SER A 235
 None
 1.26A 1p6kB-2ntbA:
undetectable		 1p6kB-2ntbA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		5 / 12 LEU A 231
LEU A 265
GLY A 266
THR A 179
ILE A 194
 None
 1.48A 1p93A-2ntbA:
undetectable		 1p93A-2ntbA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		5 / 11 THR A 294
PHE A 326
SER A 249
LEU A 208
VAL A 357
 None
 1.30A 1q23G-2ntbA:
undetectable		 1q23G-2ntbA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		5 / 11 THR A 294
PHE A 326
SER A 249
LEU A 208
VAL A 357
 None
 1.27A 1q23J-2ntbA:
undetectable		 1q23J-2ntbA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		5 / 12 THR A 160
GLY A 184
GLY A 205
GLY A 203
ASP A 164
 None
 1.19A 1wg8A-2ntbA:
undetectable		 1wg8A-2ntbA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		4 / 8 TYR A 181
GLY A 108
THR A 109
ALA A 110
 None
 0.77A 2a1hA-2ntbA:
undetectable
2a1hB-2ntbA:
undetectable		 2a1hA-2ntbA:
22.73
2a1hB-2ntbA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		4 / 8 TYR A 181
GLY A 108
THR A 109
ALA A 110
 None
 0.72A 2a1hA-2ntbA:
undetectable
2a1hB-2ntbA:
undetectable		 2a1hA-2ntbA:
22.73
2a1hB-2ntbA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		4 / 8 TYR A 181
GLY A 108
THR A 109
ALA A 110
 None
 0.52A 2ej3A-2ntbA:
undetectable		 2ej3A-2ntbA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		4 / 8 TYR A 181
GLY A 108
THR A 109
ALA A 110
 None
 0.55A 2ej3C-2ntbA:
undetectable		 2ej3C-2ntbA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		4 / 5 SER A 195
VAL A 215
SER A 172
VAL A 174
 None
 1.29A 2j9cA-2ntbA:
undetectable
2j9cB-2ntbA:
undetectable
2j9cC-2ntbA:
undetectable		 2j9cA-2ntbA:
16.88
2j9cB-2ntbA:
16.88
2j9cC-2ntbA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		5 / 12 LEU A 180
ASP A 199
THR A 289
GLY A 243
THR A 236
 None
 1.17A 2uvnA-2ntbA:
undetectable		 2uvnA-2ntbA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		5 / 12 GLN A 125
ILE A  61
VAL A 159
LEU A 157
ILE A 129
 None
 1.14A 3gwxB-2ntbA:
undetectable		 3gwxB-2ntbA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		5 / 10 ILE A 117
SER A 162
SER A 183
GLY A 163
LEU A 157
 None
 1.24A 3ik6B-2ntbA:
undetectable
3ik6E-2ntbA:
undetectable		 3ik6B-2ntbA:
22.66
3ik6E-2ntbA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		5 / 9 LEU A 157
VAL A 159
LEU A  81
ILE A  74
ALA A 124
 None
 1.10A 3mdvA-2ntbA:
undetectable		 3mdvA-2ntbA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		4 / 6 THR A 336
GLN A 343
ILE A 300
SER A 338
 None
 1.17A 3peoG-2ntbA:
undetectable		 3peoG-2ntbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		3 / 3 TYR A 301
ASP A 199
ASP A 304
 None
 0.73A 3r24A-2ntbA:
undetectable		 3r24A-2ntbA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		4 / 4 ASP A 178
ASP A 199
GLY A 203
THR A 289
 None
 1.35A 3tl9B-2ntbA:
undetectable		 3tl9B-2ntbA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		3 / 3 SER A 235
ASP A 178
ASP A 151
 None
 0.68A 3uj7A-2ntbA:
undetectable		 3uj7A-2ntbA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		5 / 12 GLN A 343
ASN A 293
ALA A 333
GLY A 332
ASN A 298
 None
 1.31A 3v3oB-2ntbA:
undetectable		 3v3oB-2ntbA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		4 / 6 ILE A 115
ILE A  63
PHE A 122
LEU A  79
 None
 0.87A 4m51A-2ntbA:
undetectable		 4m51A-2ntbA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		3 / 3 SER A 235
ASP A 178
ASP A 151
 None
 0.62A 4mwzA-2ntbA:
undetectable		 4mwzA-2ntbA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		5 / 9 THR A 179
ALA A 154
ALA A  96
GLY A 196
ASP A 134
 None
 1.08A 4qwuK-2ntbA:
undetectable
4qwuL-2ntbA:
undetectable		 4qwuK-2ntbA:
21.64
4qwuL-2ntbA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		4 / 4 ASN A  65
SER A 126
ALA A  89
VAL A  90
 None
 0.80A 4x1kC-2ntbA:
undetectable		 4x1kC-2ntbA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		3 / 3 THR A 345
ASP A 346
ALA A 347
 None
 0.11A 5g5gB-2ntbA:
undetectable		 5g5gB-2ntbA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		4 / 4 ASN A  65
SER A 126
ALA A  89
VAL A  90
 None
 0.77A 5nm5A-2ntbA:
undetectable		 5nm5A-2ntbA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		5 / 12 ILE A  45
ALA A  48
LEU A  79
ALA A  30
ILE A 129
 None
 0.88A 6a60D-2ntbA:
undetectable		 6a60D-2ntbA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_A_68HA504_0
(BETA-1 ADRENERGIC
RECEPTOR)		 2ntb PECTINESTERASE A
(Dickeya
dadantii) 		5 / 12 THR A 294
VAL A 251
PHE A 291
SER A 216
PHE A 200
 None
 1.04A 6h7mA-2ntbA:
undetectable		 6h7mA-2ntbA:
14.20