SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ntj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 2ntj ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 168
LEU A 188
SER A 143
GLY A 146
 None
 0.99A 1a4lC-2ntjA:
undetectable		 1a4lC-2ntjA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 2ntj ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH
(Mycobacterium
tuberculosis) 		4 / 7 GLN A 100
PHE A 149
MET A 199
ALA A 201
 None
P1H  A 300 (-3.5A)
None
None
 1.25A 1linA-2ntjA:
undetectable		 1linA-2ntjA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 2ntj ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  74
VAL A  78
SER A  13
LEU A  88
LEU A 246
 None
 1.24A 1mx1E-2ntjA:
3.7		 1mx1E-2ntjA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 2ntj ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH
(Mycobacterium
tuberculosis) 		4 / 8 ALA A  22
ALA A  26
ALA A 239
CYH A 243
 None
 0.93A 2vh3B-2ntjA:
undetectable		 2vh3B-2ntjA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 2ntj ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH
(Mycobacterium
tuberculosis) 		4 / 5 GLY A  90
ASP A  89
ARG A   9
GLN A  32
 None
 1.32A 3qx3A-2ntjA:
1.9		 3qx3A-2ntjA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2ntj ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  10
GLY A  90
VAL A 184
ALA A  29
VAL A 242
 None
 1.06A 5n0oA-2ntjA:
2.3		 5n0oA-2ntjA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2ntj ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  10
GLY A  90
VAL A 184
ALA A  29
VAL A 242
 None
 1.06A 5n0oB-2ntjA:
2.3		 5n0oB-2ntjA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2ntj ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  10
GLY A  90
VAL A 184
ALA A  29
VAL A 242
 None
 1.04A 5n0rA-2ntjA:
2.1		 5n0rA-2ntjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2ntj ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  10
GLY A  90
VAL A 184
ALA A  29
VAL A 242
 None
 1.05A 5n0sA-2ntjA:
2.2		 5n0sA-2ntjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2ntj ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  10
GLY A  90
VAL A 184
ALA A  29
VAL A 242
 None
 1.03A 5n0tA-2ntjA:
undetectable		 5n0tA-2ntjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2ntj ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  10
GLY A  90
VAL A 184
ALA A  29
VAL A 242
 None
 1.05A 5n0tB-2ntjA:
2.0		 5n0tB-2ntjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2ntj ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  10
GLY A  90
VAL A 184
ALA A  29
VAL A 242
 None
 1.03A 5n0wA-2ntjA:
2.3		 5n0wA-2ntjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2ntj ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  10
GLY A  90
VAL A 184
ALA A  29
VAL A 242
 None
 1.04A 5n0wB-2ntjA:
undetectable		 5n0wB-2ntjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2ntj ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  10
GLY A  90
VAL A 184
ALA A  29
VAL A 242
 None
 1.04A 5n0xA-2ntjA:
2.2		 5n0xA-2ntjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2ntj ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  10
GLY A  90
VAL A 184
ALA A  29
VAL A 242
 None
 1.04A 5n0xB-2ntjA:
2.1		 5n0xB-2ntjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2ntj ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  10
GLY A  90
VAL A 184
ALA A  29
VAL A 242
 None
 1.01A 5n4iA-2ntjA:
undetectable		 5n4iA-2ntjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2ntj ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH
(Mycobacterium
tuberculosis) 		3 / 3 TYR A 127
ALA A 133
LEU A 134
 None
 0.54A 6ag0C-2ntjA:
undetectable		 6ag0C-2ntjA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 2ntj ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH
(Mycobacterium
tuberculosis) 		5 / 12 SER A 129
SER A 126
TYR A 125
HIS A  70
LEU A  63
 None
 1.42A 6chgC-2ntjA:
undetectable		 6chgC-2ntjA:
18.18