SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ntt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)
2ntt STAPHYLOCOCCAL
ENTEROTOXIN K

(Staphylococcus
aureus)
4 / 6 HIS A 105
PHE A 207
LEU A 209
ILE A  97
None
1.16A 1sbrA-2nttA:
undetectable
1sbrB-2nttA:
undetectable
1sbrA-2nttA:
19.83
1sbrB-2nttA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)
2ntt STAPHYLOCOCCAL
ENTEROTOXIN K

(Staphylococcus
aureus)
4 / 7 PHE A 168
LEU A 180
VAL A 113
ILE A 125
None
0.94A 1t87B-2nttA:
undetectable
1t87B-2nttA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)
2ntt STAPHYLOCOCCAL
ENTEROTOXIN K

(Staphylococcus
aureus)
4 / 8 LEU A   9
ARG A  10
THR A  14
GLY A 164
None
None
EDO  A7010 ( 4.9A)
EDO  A7009 (-4.7A)
0.90A 3ny4A-2nttA:
undetectable
3ny4A-2nttA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)
2ntt STAPHYLOCOCCAL
ENTEROTOXIN K

(Staphylococcus
aureus)
5 / 7 GLY A  80
GLY A  81
SER A  46
LEU A  62
PHE A  37
None
1.25A 3o9mA-2nttA:
undetectable
3o9mA-2nttA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)
2ntt STAPHYLOCOCCAL
ENTEROTOXIN K

(Staphylococcus
aureus)
4 / 6 GLY A  80
GLY A  81
SER A  46
LEU A  62
None
0.80A 3o9mB-2nttA:
undetectable
3o9mB-2nttA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)
2ntt STAPHYLOCOCCAL
ENTEROTOXIN K

(Staphylococcus
aureus)
4 / 7 TYR A 137
ILE A  99
LEU A 180
GLY A 164
None
None
None
EDO  A7009 (-4.7A)
0.93A 4iqqA-2nttA:
undetectable
4iqqA-2nttA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)
2ntt STAPHYLOCOCCAL
ENTEROTOXIN K

(Staphylococcus
aureus)
4 / 8 TYR A 137
ILE A  99
LEU A 180
GLY A 164
None
None
None
EDO  A7009 (-4.7A)
0.83A 4iqqD-2nttA:
undetectable
4iqqD-2nttA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)
2ntt STAPHYLOCOCCAL
ENTEROTOXIN K

(Staphylococcus
aureus)
4 / 8 TYR A 137
ILE A  99
LEU A 180
GLY A 164
None
None
None
EDO  A7009 (-4.7A)
0.82A 5nooD-2nttA:
undetectable
5nooD-2nttA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)
2ntt STAPHYLOCOCCAL
ENTEROTOXIN K

(Staphylococcus
aureus)
5 / 12 LEU A 193
SER A  46
GLY A  80
GLY A  66
VAL A  19
None
1.03A 5o4yD-2nttA:
undetectable
5o4yE-2nttA:
undetectable
5o4yD-2nttA:
6.87
5o4yE-2nttA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)
2ntt STAPHYLOCOCCAL
ENTEROTOXIN K

(Staphylococcus
aureus)
4 / 6 GLN A 134
ASN A 143
SER A 159
PHE A 181
None
EDO  A7010 (-4.2A)
None
None
1.25A 6ekuA-2nttA:
undetectable
6ekuA-2nttA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)
2ntt STAPHYLOCOCCAL
ENTEROTOXIN K

(Staphylococcus
aureus)
3 / 3 LEU A 133
LEU A 180
ARG A 130
None
0.62A 6fgcA-2nttA:
undetectable
6fgcA-2nttA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)
2ntt STAPHYLOCOCCAL
ENTEROTOXIN K

(Staphylococcus
aureus)
3 / 3 LEU A 133
LEU A 180
ARG A 130
None
0.61A 6fgdA-2nttA:
undetectable
6fgdA-2nttA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)
2ntt STAPHYLOCOCCAL
ENTEROTOXIN K

(Staphylococcus
aureus)
4 / 6 LEU A 193
VAL A 120
PHE A 168
PHE A 207
None
1.05A 6h7lA-2nttA:
undetectable
6h7lA-2nttA:
13.27