SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nty'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2nty EMB|CAB41934.1
RAC-LIKE GTP-BINDING
PROTEIN ARAC5
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		5 / 12 GLY A  33
GLY A  31
GLY A  30
VAL A  34
GLY C  57
 None
 0.91A 1n2xB-2ntyA:
undetectable		 1n2xB-2ntyA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 2nty EMB|CAB41934.1
(Arabidopsis
thaliana) 		3 / 3 ARG A 118
ILE A 125
TRP A  69
 None
 1.11A 1nodB-2ntyA:
undetectable		 1nodB-2ntyA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 2nty EMB|CAB41934.1
(Arabidopsis
thaliana) 		3 / 3 ALA A 261
VAL A 263
TRP A 266
 None
 0.80A 1nt5A-2ntyA:
undetectable		 1nt5A-2ntyA:
3.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 2nty EMB|CAB41934.1
(Arabidopsis
thaliana) 		3 / 3 ALA A 261
VAL A 263
TRP A 266
 None
 0.80A 1nt5B-2ntyA:
undetectable		 1nt5B-2ntyA:
3.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 2nty RAC-LIKE GTP-BINDING
PROTEIN ARAC5
(Arabidopsis
thaliana) 		5 / 11 PHE C 170
THR C  11
GLY C  18
VAL C 116
ILE C  82
 None
None
GDP  C1200 (-2.6A)
None
None
 1.14A 1phgA-2ntyC:
undetectable		 1phgA-2ntyC:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 2nty EMB|CAB41934.1
RAC-LIKE GTP-BINDING
PROTEIN ARAC5
(Arabidopsis
thaliana) 		4 / 8 TYR A 333
ASP A 121
TRP A  69
LEU C  70
 None
 1.24A 1pk2A-2ntyA:
undetectable		 1pk2A-2ntyA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2nty RAC-LIKE GTP-BINDING
PROTEIN ARAC5
(Arabidopsis
thaliana) 		5 / 12 ILE C 154
ILE C 113
ALA C  84
PHE C  85
LEU C  87
 None
 1.07A 1uduB-2ntyC:
undetectable		 1uduB-2ntyC:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nty RAC-LIKE GTP-BINDING
PROTEIN ARAC5
(Arabidopsis
thaliana) 		5 / 11 ILE C  82
ALA C 173
ALA C 172
ASN C 165
PHE C 170
 None
 1.11A 2aclE-2ntyC:
undetectable		 2aclE-2ntyC:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nty RAC-LIKE GTP-BINDING
PROTEIN ARAC5
(Arabidopsis
thaliana) 		5 / 11 ILE C  82
ALA C 173
ALA C 172
PHE C 170
CYH C 158
 None
 1.03A 2aclE-2ntyC:
undetectable		 2aclE-2ntyC:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 2nty EMB|CAB41934.1
(Arabidopsis
thaliana) 		3 / 3 ARG A 118
ILE A 125
TRP A  69
 None
 1.10A 2nodB-2ntyA:
undetectable		 2nodB-2ntyA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 2nty RAC-LIKE GTP-BINDING
PROTEIN ARAC5
(Arabidopsis
thaliana) 		4 / 8 GLY C  77
ALA C  78
ASP C  79
THR C  61
 None
 0.58A 3el0A-2ntyC:
undetectable		 3el0A-2ntyC:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 2nty EMB|CAB41934.1
(Arabidopsis
thaliana) 		4 / 8 ALA A 341
LEU A 124
ALA A 192
ALA A 193
 None
 0.76A 3r9tA-2ntyA:
undetectable		 3r9tA-2ntyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 2nty EMB|CAB41934.1
RAC-LIKE GTP-BINDING
PROTEIN ARAC5
(Arabidopsis
thaliana) 		4 / 7 PRO A 162
ARG A 142
GLY C 134
PRO C 133
 None
 1.24A 3ucbB-2ntyA:
undetectable		 3ucbB-2ntyA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 2nty EMB|CAB41934.1
(Arabidopsis
thaliana) 		3 / 3 ASN A 197
GLU A 338
ARG A 335
 None
 1.10A 3wxoA-2ntyA:
undetectable		 3wxoA-2ntyA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2nty RAC-LIKE GTP-BINDING
PROTEIN ARAC5
(Arabidopsis
thaliana) 		5 / 10 VAL C  80
VAL C 177
ILE C 174
LEU C  23
LEU C  58
 None
 1.39A 4jtqA-2ntyC:
2.2		 4jtqA-2ntyC:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2nty EMB|CAB41934.1
RAC-LIKE GTP-BINDING
PROTEIN ARAC5
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		4 / 7 LEU C  73
ARG C  69
PRO A 207
MET A 204
 None
 1.10A 4klrA-2ntyC:
3.8		 4klrA-2ntyC:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2nty RAC-LIKE GTP-BINDING
PROTEIN ARAC5
(Arabidopsis
thaliana) 		5 / 12 ASN C 165
VAL C 166
ILE C  88
ILE C 138
SER C  89
 None
 0.97A 4xueA-2ntyC:
undetectable		 4xueA-2ntyC:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 2nty RAC-LIKE GTP-BINDING
PROTEIN ARAC5
(Arabidopsis
thaliana) 		4 / 6 ILE C 154
PRO C 153
ILE C 101
VAL C  96
 None
 1.00A 4zj8A-2ntyC:
4.4		 4zj8A-2ntyC:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 2nty EMB|CAB41934.1
RAC-LIKE GTP-BINDING
PROTEIN ARAC5
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		3 / 3 HIS C 132
SER A 144
ARG A 142
 None
 0.94A 5u63A-2ntyC:
undetectable		 5u63A-2ntyC:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 2nty EMB|CAB41934.1
(Arabidopsis
thaliana) 		5 / 12 PHE A 240
ILE A 226
LEU A 255
ALA A 295
LEU A 299
 None
 1.24A 5zwrB-2ntyA:
undetectable		 5zwrB-2ntyA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 2nty EMB|CAB41934.1
(Arabidopsis
thaliana) 		4 / 5 VAL A  79
LEU A 110
VAL A 200
LEU A 117
 None
 1.03A 6bqgA-2ntyA:
undetectable		 6bqgA-2ntyA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 2nty EMB|CAB41934.1
(Arabidopsis
thaliana) 		4 / 6 ARG A 107
ILE A 114
ASN A 113
ASP A 109
 None
 1.42A 6dhbA-2ntyA:
undetectable		 6dhbA-2ntyA:
13.22