SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nux'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		5 / 11 ASN A  59
LEU A  49
GLU A  53
ARG A 258
PHE A  11
 None
 1.19A 1l5rA-2nuxA:
undetectable		 1l5rA-2nuxA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		4 / 7 PHE A 199
LEU A 245
ASN A 179
ILE A 226
 None
 0.93A 1yc2E-2nuxA:
undetectable		 1yc2E-2nuxA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		4 / 5 ILE A 204
ILE A   8
ILE A  34
LEU A 233
 None
 0.88A 1zgyA-2nuxA:
undetectable		 1zgyA-2nuxA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		5 / 12 ALA A 269
GLU A 268
LEU A 272
LEU A 264
GLY A 255
 None
 1.09A 2jfaB-2nuxA:
undetectable		 2jfaB-2nuxA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		4 / 7 LEU A 225
LEU A 279
LEU A 286
GLU A 285
 None
 0.90A 2vq5B-2nuxA:
undetectable		 2vq5B-2nuxA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		5 / 12 PRO A  10
THR A  24
LEU A  61
ILE A  37
SER A   5
 None
 1.34A 2xrlA-2nuxA:
undetectable		 2xrlA-2nuxA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		4 / 8 ILE A 200
PHE A 249
ARG A 228
LEU A 233
 None
 0.92A 3ag3N-2nuxA:
0.0
3ag3W-2nuxA:
undetectable		 3ag3N-2nuxA:
21.12
3ag3W-2nuxA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		4 / 5 LEU A 222
LYS A 282
GLN A 284
LEU A 286
 None
 1.03A 3h5gA-2nuxA:
undetectable
3h5gB-2nuxA:
undetectable		 3h5gA-2nuxA:
7.99
3h5gB-2nuxA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		3 / 3 LEU A 225
LEU A 279
ARG A 281
 None
 0.76A 3hcnB-2nuxA:
undetectable		 3hcnB-2nuxA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		5 / 11 SER A 162
LEU A 186
SER A 185
ILE A   3
PHE A  38
 None
 1.34A 3ko0A-2nuxA:
undetectable
3ko0B-2nuxA:
undetectable
3ko0C-2nuxA:
undetectable
3ko0D-2nuxA:
undetectable		 3ko0A-2nuxA:
16.38
3ko0B-2nuxA:
16.38
3ko0C-2nuxA:
16.38
3ko0D-2nuxA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		5 / 11 LEU A 186
SER A 185
ILE A   3
PHE A  38
SER A 162
 None
 1.35A 3ko0C-2nuxA:
undetectable
3ko0D-2nuxA:
undetectable
3ko0E-2nuxA:
undetectable
3ko0F-2nuxA:
undetectable		 3ko0C-2nuxA:
16.38
3ko0D-2nuxA:
16.38
3ko0E-2nuxA:
16.38
3ko0F-2nuxA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		5 / 11 SER A 162
LEU A 186
SER A 185
ILE A   3
PHE A  38
 None
 1.33A 3ko0C-2nuxA:
undetectable
3ko0D-2nuxA:
undetectable
3ko0E-2nuxA:
undetectable
3ko0F-2nuxA:
undetectable		 3ko0C-2nuxA:
16.38
3ko0D-2nuxA:
16.38
3ko0E-2nuxA:
16.38
3ko0F-2nuxA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		5 / 11 LEU A 186
SER A 185
ILE A   3
PHE A  38
SER A 162
 None
 1.44A 3ko0E-2nuxA:
undetectable
3ko0F-2nuxA:
undetectable
3ko0G-2nuxA:
undetectable
3ko0H-2nuxA:
undetectable		 3ko0E-2nuxA:
16.38
3ko0F-2nuxA:
16.38
3ko0G-2nuxA:
16.38
3ko0H-2nuxA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		5 / 12 LEU A 186
SER A 185
ILE A   3
PHE A  38
SER A 162
 None
 1.36A 3ko0G-2nuxA:
undetectable
3ko0H-2nuxA:
undetectable
3ko0I-2nuxA:
undetectable
3ko0J-2nuxA:
undetectable		 3ko0G-2nuxA:
16.38
3ko0H-2nuxA:
16.38
3ko0I-2nuxA:
16.38
3ko0J-2nuxA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		5 / 11 SER A 162
LEU A 186
SER A 185
ILE A   3
PHE A  38
 None
 1.40A 3ko0K-2nuxA:
undetectable
3ko0L-2nuxA:
undetectable
3ko0M-2nuxA:
undetectable
3ko0N-2nuxA:
undetectable		 3ko0K-2nuxA:
16.38
3ko0L-2nuxA:
16.38
3ko0M-2nuxA:
16.38
3ko0N-2nuxA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		5 / 11 LEU A 186
SER A 185
ILE A   3
PHE A  38
SER A 162
 None
 1.37A 3ko0O-2nuxA:
undetectable
3ko0P-2nuxA:
undetectable
3ko0Q-2nuxA:
undetectable
3ko0R-2nuxA:
undetectable		 3ko0O-2nuxA:
16.38
3ko0P-2nuxA:
16.38
3ko0Q-2nuxA:
16.38
3ko0R-2nuxA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		5 / 8 ASN A  88
ILE A  92
SER A 125
SER A 122
GLY A  94
 None
 1.40A 3lslA-2nuxA:
undetectable
3lslD-2nuxA:
undetectable		 3lslA-2nuxA:
22.48
3lslD-2nuxA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		5 / 12 ILE A   4
ASN A 198
VAL A 246
ILE A  34
ALA A 194
 None
 1.23A 3ohtA-2nuxA:
undetectable
3ohtB-2nuxA:
undetectable		 3ohtA-2nuxA:
21.52
3ohtB-2nuxA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		4 / 7 PRO A   6
LEU A 186
GLY A 177
ALA A 194
 None
 0.89A 3tehB-2nuxA:
undetectable		 3tehB-2nuxA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		4 / 6 GLU A   2
ILE A   4
TYR A 127
HIS A 124
 None
 1.18A 4a97I-2nuxA:
undetectable		 4a97I-2nuxA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		4 / 5 GLY A  94
ILE A  92
VAL A  72
SER A  87
 None
 1.23A 4d33A-2nuxA:
undetectable		 4d33A-2nuxA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		4 / 8 SER A  87
ILE A   4
VAL A 193
PHE A  38
 None
 1.01A 4dx7B-2nuxA:
undetectable		 4dx7B-2nuxA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		4 / 8 TYR A 183
ILE A 211
ASP A 190
GLY A 191
 None
 0.89A 4iqqD-2nuxA:
undetectable		 4iqqD-2nuxA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		4 / 5 TYR A 129
ILE A 128
ASN A 156
ILE A 152
 None
 1.05A 4jtpA-2nuxA:
undetectable		 4jtpA-2nuxA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		4 / 8 ILE A  92
LEU A  49
VAL A  80
LEU A  83
 None
 1.02A 4r38B-2nuxA:
undetectable		 4r38B-2nuxA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		4 / 8 ARG A 234
ALA A 230
LEU A 233
GLY A 237
 None
 0.97A 4xk8a-2nuxA:
undetectable		 4xk8a-2nuxA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		4 / 7 VAL A  64
THR A  65
LEU A  22
VAL A  39
 None
 1.04A 5e4dA-2nuxA:
undetectable
5e4dB-2nuxA:
undetectable		 5e4dA-2nuxA:
21.36
5e4dB-2nuxA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		4 / 8 TYR A 183
ILE A 211
ASP A 190
GLY A 191
 None
 0.88A 5nooD-2nuxA:
undetectable		 5nooD-2nuxA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		4 / 5 LEU A 229
LYS A 280
LEU A 245
GLU A 248
 None
 1.17A 5weaA-2nuxA:
2.2		 5weaA-2nuxA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_0
(ADENOSYLHOMOCYSTEINA
SE)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		5 / 12 LEU A  68
THR A  65
ASN A 198
LEU A  22
HIS A  25
 None
 1.33A 6exiC-2nuxA:
undetectable		 6exiC-2nuxA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE
(Sulfolobus
acidocaldarius) 		5 / 12 ASN A  28
PRO A 201
VAL A 205
HIS A 288
VAL A 287
 None
 1.08A 6j21A-2nuxA:
undetectable		 6j21A-2nuxA:
20.54