SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nv2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2nv2 PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Bacillus
subtilis) 		5 / 12 ASN A  27
ALA A  39
ILE A  76
VAL A  25
ALA A  44
 None
 1.32A 1udtA-2nv2A:
undetectable		 1udtA-2nv2A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 2nv2 PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Bacillus
subtilis) 		4 / 4 ALA A 211
VAL A 234
PHE A 210
THR A 255
 None
 1.48A 2pkkA-2nv2A:
undetectable		 2pkkA-2nv2A:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2nv2 PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Bacillus
subtilis) 		5 / 12 ALA A 212
GLY A 155
PRO A 152
GLY A 150
ALA A 216
 None
 0.95A 3douA-2nv2A:
undetectable		 3douA-2nv2A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2nv2 PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Bacillus
subtilis) 		5 / 9 VAL A  88
ALA A  82
ILE A  84
ILE A  87
TYR A 121
 None
 1.30A 3hbbB-2nv2A:
undetectable		 3hbbB-2nv2A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 2nv2 PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Bacillus
subtilis) 		5 / 12 LEU A 223
GLY A 228
ALA A 229
ASP A 230
ILE A 157
 None
 0.69A 3s54B-2nv2A:
undetectable		 3s54B-2nv2A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2nv2 PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Bacillus
subtilis) 		5 / 12 LEU A 132
ILE A 199
ALA A 140
GLY A 142
ALA A 135
 None
 1.04A 4enhA-2nv2A:
undetectable		 4enhA-2nv2A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 2nv2 PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Bacillus
subtilis) 		4 / 6 SER A 104
ARG A 147
GLY A 214
GLY A 153
 None
 0.86A 4koeA-2nv2A:
undetectable
4koeB-2nv2A:
undetectable
4koeC-2nv2A:
undetectable		 4koeA-2nv2A:
20.85
4koeB-2nv2A:
20.85
4koeC-2nv2A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 2nv2 PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Bacillus
subtilis) 		4 / 7 ARG A 147
SER A 104
GLY A 214
GLY A 153
 None
 0.86A 4koeA-2nv2A:
undetectable
4koeB-2nv2A:
undetectable
4koeD-2nv2A:
undetectable		 4koeA-2nv2A:
20.85
4koeB-2nv2A:
20.85
4koeD-2nv2A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 2nv2 PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Bacillus
subtilis) 		4 / 6 GLY A 214
GLY A 153
SER A 104
ARG A 147
 None
 0.81A 4z53A-2nv2A:
undetectable
4z53B-2nv2A:
undetectable		 4z53A-2nv2A:
18.27
4z53B-2nv2A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 2nv2 PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Bacillus
subtilis) 		4 / 7 ARG A 147
GLY A 214
GLY A 153
SER A 104
 None
 0.80A 4z53A-2nv2A:
undetectable
4z53B-2nv2A:
undetectable		 4z53A-2nv2A:
18.27
4z53B-2nv2A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 2nv2 PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Bacillus
subtilis) 		5 / 12 LEU A 223
GLY A 228
ALA A 229
ASP A 230
ILE A 157
 None
 0.61A 5e5jA-2nv2A:
undetectable		 5e5jA-2nv2A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 2nv2 PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Bacillus
subtilis) 		5 / 12 LEU A 223
GLY A 228
ALA A 229
ASP A 230
ILE A 157
 None
 0.62A 5e5kB-2nv2A:
undetectable		 5e5kB-2nv2A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 2nv2 PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Bacillus
subtilis) 		5 / 12 LEU A 223
GLY A 228
ALA A 229
ASP A 230
ILE A 157
 None
 0.60A 6dh3A-2nv2A:
undetectable		 6dh3A-2nv2A:
14.63