SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nv4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 2nv4 UPF0066 PROTEIN
AF_0241
(Archaeoglobus
fulgidus) 		3 / 3 VAL A  68
GLU A  74
GLU A  75
 None
ACT  A 148 (-3.6A)
None
 0.02A 2nv4A-2nv4A:
27.8		 2nv4A-2nv4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 2nv4 UPF0066 PROTEIN
AF_0241
(Archaeoglobus
fulgidus) 		12 / 12 GLN A  16
ALA A  19
GLN A  22
TYR A  55
ASP A  58
LYS A  59
PRO A  84
GLY A  91
LEU A  92
ASP A 111
LEU A 113
SER A 116
 None
SAM  A 201 (-3.6A)
SAM  A 201 (-2.9A)
SAM  A 201 (-4.8A)
SAM  A 201 (-3.5A)
None
SAM  A 201 ( 4.3A)
SAM  A 201 (-3.5A)
SAM  A 201 (-4.4A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.6A)
SAM  A 201 (-2.7A)
 0.02A 2nv4A-2nv4A:
27.8		 2nv4A-2nv4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 2nv4 UPF0066 PROTEIN
AF_0241
(Archaeoglobus
fulgidus) 		11 / 12 GLN A  16
ALA A  19
GLN A  22
TYR A  55
ASP A  58
PRO A  84
GLY A  91
LEU A  92
ASP A 111
LEU A 113
SER A 116
 None
SAM  A 201 (-3.6A)
SAM  A 201 (-2.9A)
SAM  A 201 (-4.8A)
SAM  A 201 (-3.5A)
SAM  A 201 ( 4.3A)
SAM  A 201 (-3.5A)
SAM  A 201 (-4.4A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.6A)
SAM  A 201 (-2.7A)
 0.41A 2nv4B-2nv4A:
25.9		 2nv4B-2nv4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 2nv4 UPF0066 PROTEIN
AF_0241
(Archaeoglobus
fulgidus) 		8 / 12 GLN A  16
GLN A  22
TYR A  55
ASP A  58
LYS A  59
PRO A  84
GLY A  91
LEU A  92
 None
SAM  A 201 (-2.9A)
SAM  A 201 (-4.8A)
SAM  A 201 (-3.5A)
None
SAM  A 201 ( 4.3A)
SAM  A 201 (-3.5A)
SAM  A 201 (-4.4A)
 0.69A 2nv4B-2nv4A:
25.9		 2nv4B-2nv4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 2nv4 UPF0066 PROTEIN
AF_0241
(Archaeoglobus
fulgidus) 		5 / 12 TYR A  55
PRO A  89
GLY A  91
LEU A  92
SER A 116
 SAM  A 201 (-4.8A)
None
SAM  A 201 (-3.5A)
SAM  A 201 (-4.4A)
SAM  A 201 (-2.7A)
 1.04A 2nv4B-2nv4A:
25.9		 2nv4B-2nv4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2nv4 UPF0066 PROTEIN
AF_0241
(Archaeoglobus
fulgidus) 		5 / 12 GLU A  37
ILE A 121
LEU A 105
GLY A   7
ILE A   6
 None
 1.36A 2ogyB-2nv4A:
undetectable		 2ogyB-2nv4A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 2nv4 UPF0066 PROTEIN
AF_0241
(Archaeoglobus
fulgidus) 		4 / 7 PHE A  35
ILE A  34
ILE A 121
GLY A 115
 None
 0.93A 2v0mB-2nv4A:
undetectable		 2v0mB-2nv4A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2nv4 UPF0066 PROTEIN
AF_0241
(Archaeoglobus
fulgidus) 		5 / 10 ASP A 120
ALA A  33
ILE A  32
GLY A  41
GLY A   7
 None
 1.04A 5i6xA-2nv4A:
undetectable		 5i6xA-2nv4A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 2nv4 UPF0066 PROTEIN
AF_0241
(Archaeoglobus
fulgidus) 		4 / 8 ILE A   6
ILE A  51
GLU A  46
LEU A  42
 None
 0.78A 5og9A-2nv4A:
undetectable		 5og9A-2nv4A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2nv4 UPF0066 PROTEIN
AF_0241
(Archaeoglobus
fulgidus) 		5 / 9 ASP A 120
ALA A  33
ILE A  32
GLY A  41
GLY A   7
 None
 1.05A 6awoA-2nv4A:
undetectable		 6awoA-2nv4A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2nv4 UPF0066 PROTEIN
AF_0241
(Archaeoglobus
fulgidus) 		5 / 9 ASP A 120
ALA A  33
ILE A  32
GLY A  41
GLY A   7
 None
 1.06A 6awqA-2nv4A:
undetectable		 6awqA-2nv4A:
11.62