SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nv9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 2nv9 A207R PROTEIN,
ARGININE
DECARBOXYLASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 11 SER A 291
GLY A 321
CYH A 322
THR A 323
GLY A 365
 None
 1.36A 1jr1A-2nv9A:
5.1		 1jr1A-2nv9A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2nv9 A207R PROTEIN,
ARGININE
DECARBOXYLASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 PHE A  66
PRO A 253
THR A  42
LEU A  30
ILE A  31
 None
 1.49A 2fj1A-2nv9A:
undetectable		 2fj1A-2nv9A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 2nv9 A207R PROTEIN,
ARGININE
DECARBOXYLASE
(Paramecium
bursaria
Chlorella
virus
1) 		3 / 3 PRO A 316
GLY A 276
TYR A 278
 None
 0.69A 2vouA-2nv9A:
undetectable		 2vouA-2nv9A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_A_AG2A1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2nv9 A207R PROTEIN,
ARGININE
DECARBOXYLASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 9 LYS A  48
HIS A 176
GLY A 178
SER A 179
LEU A 357
 PLP  A2001 (-2.1A)
PLP  A2001 (-4.1A)
None
PLP  A2001 (-2.6A)
None
 0.85A 3n2oA-2nv9A:
13.2
3n2oB-2nv9A:
9.5		 3n2oA-2nv9A:
21.99
3n2oB-2nv9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_B_AG2B1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2nv9 A207R PROTEIN,
ARGININE
DECARBOXYLASE
(Paramecium
bursaria
Chlorella
virus
1) 		6 / 9 LYS A  48
HIS A 176
GLY A 178
SER A 179
TYR A 353
LEU A 357
 PLP  A2001 (-2.1A)
PLP  A2001 (-4.1A)
None
PLP  A2001 (-2.6A)
PLP  A2001 (-4.4A)
None
 0.76A 3n2oA-2nv9A:
13.2
3n2oB-2nv9A:
9.5		 3n2oA-2nv9A:
21.99
3n2oB-2nv9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2nv9 A207R PROTEIN,
ARGININE
DECARBOXYLASE
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 8 LYS A  48
HIS A 176
SER A 179
LEU A 357
 PLP  A2001 (-2.1A)
PLP  A2001 (-4.1A)
PLP  A2001 (-2.6A)
None
 0.73A 3n2oC-2nv9A:
12.3
3n2oD-2nv9A:
13.1		 3n2oC-2nv9A:
21.99
3n2oD-2nv9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_D_AG2D1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2nv9 A207R PROTEIN,
ARGININE
DECARBOXYLASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 10 LYS A  48
GLY A 178
ARG A 255
TYR A 353
LEU A 357
 PLP  A2001 (-2.1A)
None
PLP  A2001 (-4.8A)
PLP  A2001 (-4.4A)
None
 0.98A 3n2oC-2nv9A:
11.7
3n2oD-2nv9A:
23.8		 3n2oC-2nv9A:
21.99
3n2oD-2nv9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_D_AG2D1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2nv9 A207R PROTEIN,
ARGININE
DECARBOXYLASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 10 LYS A  48
HIS A 176
GLY A 178
TYR A 353
LEU A 357
 PLP  A2001 (-2.1A)
PLP  A2001 (-4.1A)
None
PLP  A2001 (-4.4A)
None
 0.84A 3n2oC-2nv9A:
11.7
3n2oD-2nv9A:
23.8		 3n2oC-2nv9A:
21.99
3n2oD-2nv9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 2nv9 A207R PROTEIN,
ARGININE
DECARBOXYLASE
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 8 TYR A 187
ASP A 212
VAL A  41
LEU A 217
 None
 1.00A 4f8hA-2nv9A:
undetectable
4f8hB-2nv9A:
undetectable		 4f8hA-2nv9A:
22.83
4f8hB-2nv9A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 2nv9 A207R PROTEIN,
ARGININE
DECARBOXYLASE
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 8 TYR A 187
ASP A 212
VAL A  41
LEU A 217
 None
 1.08A 4f8hB-2nv9A:
undetectable
4f8hC-2nv9A:
undetectable		 4f8hB-2nv9A:
22.83
4f8hC-2nv9A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 2nv9 A207R PROTEIN,
ARGININE
DECARBOXYLASE
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 8 TYR A 187
ASP A 212
VAL A  41
LEU A 217
 None
 1.02A 4f8hC-2nv9A:
undetectable
4f8hD-2nv9A:
undetectable		 4f8hC-2nv9A:
22.83
4f8hD-2nv9A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 2nv9 A207R PROTEIN,
ARGININE
DECARBOXYLASE
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 8 TYR A 187
ASP A 212
VAL A  41
LEU A 217
 None
 1.02A 4f8hD-2nv9A:
undetectable
4f8hE-2nv9A:
undetectable		 4f8hD-2nv9A:
22.83
4f8hE-2nv9A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 2nv9 A207R PROTEIN,
ARGININE
DECARBOXYLASE
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 8 VAL A  41
LEU A 217
TYR A 187
ASP A 212
 None
 1.05A 4f8hA-2nv9A:
undetectable
4f8hE-2nv9A:
undetectable		 4f8hA-2nv9A:
22.83
4f8hE-2nv9A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2nv9 A207R PROTEIN,
ARGININE
DECARBOXYLASE
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 6 ILE A  31
ILE A  26
SER A  23
LEU A  55
 None
 0.99A 4m51A-2nv9A:
3.2		 4m51A-2nv9A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 2nv9 A207R PROTEIN,
ARGININE
DECARBOXYLASE
(Paramecium
bursaria
Chlorella
virus
1) 		3 / 3 ALA A 265
TRP A 344
VAL A 345
 None
 0.41A 4w9nC-2nv9A:
undetectable		 4w9nC-2nv9A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 2nv9 A207R PROTEIN,
ARGININE
DECARBOXYLASE
(Paramecium
bursaria
Chlorella
virus
1) 		3 / 3 ASN A   6
ASP A 343
GLY A 342
 None
 0.65A 5fctB-2nv9A:
undetectable		 5fctB-2nv9A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 2nv9 A207R PROTEIN,
ARGININE
DECARBOXYLASE
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 5 PHE A 290
SER A 285
ASN A  50
ASP A  52
 None
 1.02A 5kpcA-2nv9A:
undetectable		 5kpcA-2nv9A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 2nv9 A207R PROTEIN,
ARGININE
DECARBOXYLASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 GLY A 146
GLY A 150
ASN A 147
CYH A 136
PHE A 175
 None
 1.29A 5yf0A-2nv9A:
undetectable		 5yf0A-2nv9A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 2nv9 A207R PROTEIN,
ARGININE
DECARBOXYLASE
(Paramecium
bursaria
Chlorella
virus
1) 		3 / 3 TRP A 350
GLU A 259
GLU A 296
 None
 0.68A 6fhwA-2nv9A:
undetectable		 6fhwA-2nv9A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 2nv9 A207R PROTEIN,
ARGININE
DECARBOXYLASE
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 8 TYR A 280
PHE A 282
PHE A 347
VAL A 334
 None
 0.96A 6huoC-2nv9A:
undetectable
6huoD-2nv9A:
undetectable		 6huoC-2nv9A:
13.51
6huoD-2nv9A:
13.17