SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nvo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 2nvo RO SIXTY-RELATED
PROTEIN, RSR
(Deinococcus
radiodurans) 		4 / 6 ALA A 114
ASP A 121
ALA A 122
LEU A  85
 None
 0.44A 1iwhA-2nvoA:
undetectable		 1iwhA-2nvoA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2nvo RO SIXTY-RELATED
PROTEIN, RSR
(Deinococcus
radiodurans) 		4 / 7 TYR A 460
ILE A 395
PHE A 515
ALA A 388
 None
 1.07A 1oniD-2nvoA:
undetectable
1oniE-2nvoA:
undetectable		 1oniD-2nvoA:
14.77
1oniE-2nvoA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2nvo RO SIXTY-RELATED
PROTEIN, RSR
(Deinococcus
radiodurans) 		4 / 6 PHE A 515
ALA A 388
TYR A 460
ILE A 395
 None
 1.09A 1oniH-2nvoA:
undetectable
1oniI-2nvoA:
undetectable		 1oniH-2nvoA:
14.77
1oniI-2nvoA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 2nvo RO SIXTY-RELATED
PROTEIN, RSR
(Deinococcus
radiodurans) 		5 / 12 LEU A 168
ALA A 167
MET A 204
LEU A 185
THR A 192
 None
 1.47A 2aa6B-2nvoA:
undetectable		 2aa6B-2nvoA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 2nvo RO SIXTY-RELATED
PROTEIN, RSR
(Deinococcus
radiodurans) 		5 / 12 ALA A 365
LEU A 404
VAL A 491
PRO A 443
PHE A 408
 None
 0.96A 2f8lA-2nvoA:
undetectable		 2f8lA-2nvoA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 2nvo RO SIXTY-RELATED
PROTEIN, RSR
(Deinococcus
radiodurans) 		5 / 9 LEU A 364
ILE A 395
ALA A 391
GLY A 493
LEU A 494
 None
 0.85A 2v0mB-2nvoA:
undetectable		 2v0mB-2nvoA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2nvo RO SIXTY-RELATED
PROTEIN, RSR
(Deinococcus
radiodurans) 		4 / 8 LEU A 313
VAL A 492
LEU A 494
VAL A 512
 None
 0.83A 2zujA-2nvoA:
undetectable		 2zujA-2nvoA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 2nvo RO SIXTY-RELATED
PROTEIN, RSR
(Deinococcus
radiodurans) 		4 / 7 TYR A 259
GLU A 247
TRP A 270
LEU A 278
 None
 1.29A 3k8mB-2nvoA:
undetectable		 3k8mB-2nvoA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 2nvo RO SIXTY-RELATED
PROTEIN, RSR
(Deinococcus
radiodurans) 		5 / 12 LEU A 364
ILE A 395
ALA A 391
ALA A 378
GLY A 493
 None
 0.87A 3nxuA-2nvoA:
undetectable		 3nxuA-2nvoA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2nvo RO SIXTY-RELATED
PROTEIN, RSR
(Deinococcus
radiodurans) 		4 / 6 ASP A 462
ALA A 496
THR A 461
THR A 465
 CA  A 533 ( 4.3A)
None
None
None
 1.45A 4w5qA-2nvoA:
2.9		 4w5qA-2nvoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2nvo RO SIXTY-RELATED
PROTEIN, RSR
(Deinococcus
radiodurans) 		4 / 6 ASP A 462
ALA A 496
THR A 461
THR A 465
 CA  A 533 ( 4.3A)
None
None
None
 1.48A 4w5rA-2nvoA:
undetectable		 4w5rA-2nvoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2nvo RO SIXTY-RELATED
PROTEIN, RSR
(Deinococcus
radiodurans) 		4 / 6 ASP A 462
ALA A 496
THR A 461
THR A 465
 CA  A 533 ( 4.3A)
None
None
None
 1.44A 4w5tA-2nvoA:
undetectable		 4w5tA-2nvoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2nvo RO SIXTY-RELATED
PROTEIN, RSR
(Deinococcus
radiodurans) 		4 / 6 ASP A 462
ALA A 496
THR A 461
THR A 465
 CA  A 533 ( 4.3A)
None
None
None
 1.46A 4z4cA-2nvoA:
2.9		 4z4cA-2nvoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2nvo RO SIXTY-RELATED
PROTEIN, RSR
(Deinococcus
radiodurans) 		4 / 6 ASP A 462
ALA A 496
THR A 461
THR A 465
 CA  A 533 ( 4.3A)
None
None
None
 1.44A 4z4fA-2nvoA:
3.4		 4z4fA-2nvoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2nvo RO SIXTY-RELATED
PROTEIN, RSR
(Deinococcus
radiodurans) 		4 / 5 ASP A 462
ALA A 496
THR A 461
THR A 465
 CA  A 533 ( 4.3A)
None
None
None
 1.47A 4z4gA-2nvoA:
4.0		 4z4gA-2nvoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 2nvo RO SIXTY-RELATED
PROTEIN, RSR
(Deinococcus
radiodurans) 		4 / 5 VAL A 491
VAL A 513
GLY A 514
PHE A 499
 None
 0.87A 5d4nA-2nvoA:
undetectable
5d4nC-2nvoA:
undetectable		 5d4nA-2nvoA:
11.62
5d4nC-2nvoA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 2nvo RO SIXTY-RELATED
PROTEIN, RSR
(Deinococcus
radiodurans) 		3 / 3 GLY A 436
GLY A 437
GLN A 442
 None
 0.21A 5imsA-2nvoA:
4.5		 5imsA-2nvoA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2nvo RO SIXTY-RELATED
PROTEIN, RSR
(Deinococcus
radiodurans) 		3 / 3 VAL A 200
HIS A 223
VAL A 219
 None
 0.68A 5jmnC-2nvoA:
3.6		 5jmnC-2nvoA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2nvo RO SIXTY-RELATED
PROTEIN, RSR
(Deinococcus
radiodurans) 		5 / 12 ALA A 502
VAL A 512
GLY A 514
ALA A  56
SER A  57
 None
 1.09A 5kirB-2nvoA:
undetectable		 5kirB-2nvoA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 2nvo RO SIXTY-RELATED
PROTEIN, RSR
(Deinococcus
radiodurans) 		5 / 10 PRO A 401
LEU A 397
ILE A 417
ALA A 426
PRO A 357
 None
 1.23A 5m0oA-2nvoA:
undetectable		 5m0oA-2nvoA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 2nvo RO SIXTY-RELATED
PROTEIN, RSR
(Deinococcus
radiodurans) 		5 / 9 LEU A 313
ALA A 517
PHE A 515
ASP A 516
ILE A 395
 None
 1.13A 5om2A-2nvoA:
undetectable
5om2B-2nvoA:
undetectable		 5om2A-2nvoA:
10.15
5om2B-2nvoA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2nvo RO SIXTY-RELATED
PROTEIN, RSR
(Deinococcus
radiodurans) 		5 / 12 PHE A 408
VAL A 368
ALA A 426
PRO A 443
ALA A 430
 None
 1.39A 5tzoA-2nvoA:
undetectable		 5tzoA-2nvoA:
16.26