SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nvu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		4 / 6 VAL B1009
VAL B1051
ILE B1061
ASN B1268
 None
 0.98A 1e06A-2nvuB:
undetectable		 1e06A-2nvuB:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		4 / 8 SER B1256
THR B1226
ASN B1151
LEU B1248
 None
 0.96A 1lhvA-2nvuB:
undetectable		 1lhvA-2nvuB:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		5 / 12 LEU B1161
GLY B1192
LEU B1199
MET B1205
LEU B1152
 None
 1.30A 1nhzA-2nvuB:
undetectable		 1nhzA-2nvuB:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		5 / 12 LEU B1161
VAL B1358
LEU B1199
MET B1205
LEU B1152
 None
 1.38A 1nhzA-2nvuB:
undetectable		 1nhzA-2nvuB:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		5 / 12 ILE B2192
LEU B2145
LEU B2158
GLY B2156
TYR B2135
 None
ATP  B 103 ( 4.9A)
None
None
None
 1.15A 1tlsA-2nvuB:
undetectable		 1tlsA-2nvuB:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		5 / 12 ILE B2192
LEU B2145
LEU B2158
GLY B2156
TYR B2135
 None
ATP  B 103 ( 4.9A)
None
None
None
 1.15A 1tlsB-2nvuB:
undetectable		 1tlsB-2nvuB:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		5 / 12 ILE B2192
LEU B2145
LEU B2158
GLY B2156
TYR B2135
 None
ATP  B 103 ( 4.9A)
None
None
None
 1.15A 1tsnA-2nvuB:
undetectable		 1tsnA-2nvuB:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		5 / 10 LEU B1193
LEU B1196
ILE B1162
GLU B1154
LEU B1152
 None
 1.24A 1wopA-2nvuB:
undetectable		 1wopA-2nvuB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		5 / 10 ARG B2151
ASP B2079
GLY B2060
GLY B2057
ILE B2127
 None
ATP  B 103 (-2.8A)
None
ATP  B 103 (-4.9A)
ATP  B 103 (-3.9A)
 0.95A 1x7pA-2nvuB:
3.8
1x7pB-2nvuB:
2.6		 1x7pA-2nvuB:
16.50
1x7pB-2nvuB:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
NEDD8-CONJUGATING
ENZYME UBC12
(Homo
sapiens;
Homo
sapiens) 		3 / 3 THR B2430
ASP C  37
SER C 127
 None
 0.79A 2nxeA-2nvuB:
5.7		 2nxeA-2nvuB:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
NEDD8-CONJUGATING
ENZYME UBC12
(Homo
sapiens;
Homo
sapiens) 		3 / 3 THR B2430
ASP C  37
SER C 127
 None
 0.85A 2nxeB-2nvuB:
5.7		 2nxeB-2nvuB:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
NEDD8-CONJUGATING
ENZYME UBC12
(Homo
sapiens) 		5 / 12 SER B2396
PHE C  80
ILE C 125
ASN C 126
PHE C  60
 None
 1.39A 2vdyA-2nvuB:
undetectable		 2vdyA-2nvuB:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
NEDD8-CONJUGATING
ENZYME UBC12
(Homo
sapiens) 		5 / 12 SER B2396
PHE C  80
ILE C 125
ASN C 126
PHE C  60
 None
 1.28A 2vdyB-2nvuB:
undetectable		 2vdyB-2nvuB:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		4 / 6 LEU B1248
ILE B1227
ILE B1349
LEU B1193
 None
 0.95A 2xkwB-2nvuB:
undetectable		 2xkwB-2nvuB:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		5 / 12 ILE B1109
LEU B1263
ILE B1060
VAL B1024
LEU B1021
 None
 1.05A 3a51C-2nvuB:
undetectable		 3a51C-2nvuB:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		4 / 8 VAL B1344
GLY B1183
GLY B1188
ALA B1189
 None
 0.74A 3aruA-2nvuB:
undetectable		 3aruA-2nvuB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		4 / 6 ASN B1268
SER B1271
ALA B1270
ASP B1056
 None
 1.24A 3aruA-2nvuB:
undetectable		 3aruA-2nvuB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		5 / 12 GLY B2055
LEU B2063
ASP B2079
ASP B2081
LEU B2145
 ATP  B 103 ( 4.1A)
None
ATP  B 103 (-2.8A)
ATP  B 103 (-3.8A)
ATP  B 103 ( 4.9A)
 1.00A 3cjtC-2nvuB:
5.5		 3cjtC-2nvuB:
15.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		4 / 7 GLU B1154
TYR B1156
MET B1331
TRP B1341
 None
 0.79A 3jyrA-2nvuB:
45.8		 3jyrA-2nvuB:
42.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		5 / 12 GLY B2060
GLY B2144
ALA B2104
ALA B2107
LEU B2064
 None
 1.13A 3mteA-2nvuB:
5.3		 3mteA-2nvuB:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
NEDD8-CONJUGATING
ENZYME UBC12
(Homo
sapiens) 		5 / 10 ILE C  49
PHE C  51
ILE C 125
LEU C  57
SER B2396
 None
 1.09A 3o1cA-2nvuC:
undetectable		 3o1cA-2nvuC:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
NEDD8-CONJUGATING
ENZYME UBC12
(Homo
sapiens) 		5 / 10 ILE C  49
PHE C  51
ILE C 125
LEU C  57
SER B2396
 None
 1.09A 3o1xA-2nvuC:
undetectable		 3o1xA-2nvuC:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
NEDD8-CONJUGATING
ENZYME UBC12
(Homo
sapiens) 		5 / 10 ILE C  49
PHE C  51
ILE C 125
LEU C  57
SER B2396
 None
 1.12A 3qgzA-2nvuC:
undetectable		 3qgzA-2nvuC:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		3 / 3 PRO B1041
ASP B1042
GLU B1045
 None
 0.88A 3v4tC-2nvuB:
undetectable		 3v4tC-2nvuB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2nvu NEDD8-CONJUGATING
ENZYME UBC12
(Homo
sapiens) 		5 / 12 TYR C  86
ILE C  34
ILE C 129
LEU C 132
VAL C 110
 None
 1.11A 3w68B-2nvuC:
undetectable		 3w68B-2nvuC:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		4 / 6 CYH B2202
THR B2203
CYH B2343
ILE B2159
 ZN  B 102 (-2.4A)
None
ZN  B 102 (-2.4A)
None
 1.30A 3w9tB-2nvuB:
undetectable		 3w9tB-2nvuB:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		4 / 6 PRO B2171
LEU B2162
ASN B2163
GLU B2165
 None
 0.99A 3zqtA-2nvuB:
undetectable		 3zqtA-2nvuB:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
NEDD8-CONJUGATING
ENZYME UBC12
(Homo
sapiens) 		5 / 12 SER B2396
PHE C  80
ILE C 125
ASN C 126
PHE C  60
 None
 1.31A 4c49B-2nvuB:
undetectable		 4c49B-2nvuB:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
NEDD8-CONJUGATING
ENZYME UBC12
(Homo
sapiens) 		5 / 12 SER B2396
PHE C  80
ILE C 125
ASN C 126
PHE C  60
 None
 1.33A 4c49C-2nvuB:
undetectable		 4c49C-2nvuB:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
NEDD8-CONJUGATING
ENZYME UBC12
(Homo
sapiens) 		5 / 12 SER B2396
PHE C  80
ILE C 125
ASN C 126
PHE C  60
 None
 1.39A 4c49D-2nvuB:
undetectable		 4c49D-2nvuB:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		4 / 8 SER B1353
ARG B1355
ILE B1349
ASP B1208
 None
 1.11A 4d39A-2nvuB:
undetectable		 4d39A-2nvuB:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		4 / 7 SER B1353
ARG B1355
ILE B1349
ASP B1208
 None
 1.07A 4d39B-2nvuB:
undetectable		 4d39B-2nvuB:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		4 / 7 ASP B2252
ASP B2146
ASN B2087
ASP B2081
 None
MG  B 101 ( 3.1A)
ATP  B 103 (-3.6A)
ATP  B 103 (-3.8A)
 1.17A 4feuB-2nvuB:
undetectable		 4feuB-2nvuB:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		5 / 12 ILE B2192
LEU B2145
LEU B2158
GLY B2156
TYR B2135
 None
ATP  B 103 ( 4.9A)
None
None
None
 1.18A 4foxB-2nvuB:
undetectable		 4foxB-2nvuB:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		5 / 12 ILE B2192
LEU B2145
LEU B2158
GLY B2156
TYR B2135
 None
ATP  B 103 ( 4.9A)
None
None
None
 1.24A 4foxG-2nvuB:
undetectable		 4foxG-2nvuB:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		4 / 6 ASP B2252
ASP B2146
ASN B2087
ASP B2081
 None
MG  B 101 ( 3.1A)
ATP  B 103 (-3.6A)
ATP  B 103 (-3.8A)
 1.34A 4gkhJ-2nvuB:
undetectable		 4gkhJ-2nvuB:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		4 / 8 ASP B2146
ASP B2084
ASP B2081
ASP B2250
 MG  B 101 ( 3.1A)
None
ATP  B 103 (-3.8A)
None
 0.91A 4gkhC-2nvuB:
undetectable
4gkhK-2nvuB:
undetectable		 4gkhC-2nvuB:
17.17
4gkhK-2nvuB:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		4 / 8 ASP B2146
ASP B2084
ASP B2081
ASP B2250
 MG  B 101 ( 3.1A)
None
ATP  B 103 (-3.8A)
None
 0.88A 4gkiE-2nvuB:
undetectable
4gkiG-2nvuB:
undetectable		 4gkiE-2nvuB:
17.17
4gkiG-2nvuB:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		4 / 6 PHE B2436
TYR B2367
LEU B2368
THR B2430
 None
 1.20A 4paeA-2nvuB:
undetectable		 4paeA-2nvuB:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		5 / 12 THR B2182
ASP B2179
LEU B2063
LEU B2059
GLY B2058
 None
None
None
None
ATP  B 103 ( 4.2A)
 1.46A 4pfjB-2nvuB:
5.9		 4pfjB-2nvuB:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
NEDD8-CONJUGATING
ENZYME UBC12
(Homo
sapiens) 		4 / 8 ILE B2400
LEU C  32
VAL C  82
LEU C  58
 None
 1.00A 4r38B-2nvuB:
undetectable		 4r38B-2nvuB:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		5 / 8 LEU B1291
GLY B1290
GLU B1292
GLU B1023
ALA B1022
 None
 1.25A 4rjdA-2nvuB:
undetectable
4rjdB-2nvuB:
undetectable		 4rjdA-2nvuB:
7.16
4rjdB-2nvuB:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		5 / 10 ILE B1162
PHE B1259
GLY B1328
ALA B1164
ASP B1165
 None
 1.38A 5ajqB-2nvuB:
undetectable		 5ajqB-2nvuB:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		5 / 12 GLY B2055
ASP B2079
ILE B2127
LEU B2063
LEU B2145
 ATP  B 103 ( 4.1A)
ATP  B 103 (-2.8A)
ATP  B 103 (-3.9A)
None
ATP  B 103 ( 4.9A)
 1.10A 5bw4A-2nvuB:
5.2		 5bw4A-2nvuB:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		4 / 7 LEU B1077
TYR B1071
GLY B1266
ALA B1265
 None
 0.82A 5f1aB-2nvuB:
undetectable		 5f1aB-2nvuB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		5 / 11 ILE B2192
LEU B2145
LEU B2158
GLY B2156
TYR B2135
 None
ATP  B 103 ( 4.9A)
None
None
None
 1.15A 5fctA-2nvuB:
undetectable		 5fctA-2nvuB:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		4 / 8 LEU B1291
LEU B1263
THR B1094
GLN B1326
 None
 1.18A 5hbsA-2nvuB:
undetectable		 5hbsA-2nvuB:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
NEDD8-CONJUGATING
ENZYME UBC12
(Homo
sapiens) 		5 / 10 GLY B2251
VAL B2285
GLU C 117
ASP B2253
ILE B2257
 None
 1.19A 5i3cB-2nvuB:
undetectable		 5i3cB-2nvuB:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		4 / 6 PHE B2213
PRO B2214
ARG B2223
ILE B2218
 None
 1.31A 5ih0A-2nvuB:
undetectable		 5ih0A-2nvuB:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 2nvu NEDD8-CONJUGATING
ENZYME UBC12
(Homo
sapiens) 		4 / 6 PRO C 139
GLY C  69
PHE C 160
ARG C 157
 None
 0.90A 5jcnB-2nvuC:
undetectable		 5jcnB-2nvuC:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		5 / 11 GLU B1222
GLY B1144
LEU B1123
THR B1223
ALA B1224
 None
 1.09A 5o96A-2nvuB:
4.6
5o96B-2nvuB:
4.2		 5o96A-2nvuB:
15.66
5o96B-2nvuB:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2nvu NEDD8-CONJUGATING
ENZYME UBC12
(Homo
sapiens) 		4 / 7 PHE C  70
VAL C 164
HIS C 101
PRO C 102
 None
 0.78A 5vkqA-2nvuC:
undetectable
5vkqD-2nvuC:
undetectable		 5vkqA-2nvuC:
7.56
5vkqD-2nvuC:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		6 / 12 ALA B1343
ALA B1339
GLY B1167
ALA B1189
PHE B1170
VAL B1182
 None
 1.48A 5w4zA-2nvuB:
undetectable		 5w4zA-2nvuB:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		4 / 8 GLY B2100
ILE B2099
ASP B2252
PRO B2254
 None
 0.92A 6ag0A-2nvuB:
undetectable		 6ag0A-2nvuB:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		4 / 8 GLY B2100
ILE B2099
ASP B2252
PRO B2254
 None
 0.92A 6ag0C-2nvuB:
undetectable		 6ag0C-2nvuB:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		4 / 8 SER B1353
ARG B1355
GLN B1153
ASP B1208
 None
 1.31A 6auuB-2nvuB:
undetectable		 6auuB-2nvuB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		5 / 11 PRO B1134
GLU B1131
PRO B1255
ALA B1164
PRO B1160
 None
 1.40A 6bm5A-2nvuB:
undetectable		 6bm5A-2nvuB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		5 / 11 GLY B2057
LEU B2064
ALA B2108
PHE B2094
ALA B2104
 ATP  B 103 (-4.9A)
None
None
None
None
 1.18A 6qgbA-2nvuB:
0.0		 6qgbA-2nvuB:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		5 / 11 GLY B2057
LEU B2064
ALA B2108
PHE B2094
ALA B2104
 ATP  B 103 (-4.9A)
None
None
None
None
 1.19A 6qgbE-2nvuB:
undetectable		 6qgbE-2nvuB:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens) 		5 / 12 ILE B2192
LEU B2145
LEU B2158
GLY B2156
TYR B2135
 None
ATP  B 103 ( 4.9A)
None
None
None
 1.16A 6r2eA-2nvuB:
undetectable		 6r2eA-2nvuB:
17.42