SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nvv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		3 / 3 PHE A  26
LEU A 330
SER A 308
 PHE  A  26 ( 1.3A)
LEU  A 330 ( 0.6A)
SER  A 308 ( 0.0A)
 0.92A 1e7aA-2nvvA:
undetectable		 1e7aA-2nvvA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 LEU A 307
LEU A 330
GLY A 304
MET A 281
MET A 294
 LEU  A 307 ( 0.6A)
LEU  A 330 ( 0.6A)
GLY  A 304 ( 0.0A)
PHE  A 279 ( 3.6A)
ILE  A 328 ( 3.9A)
 1.48A 1p93A-2nvvA:
undetectable		 1p93A-2nvvA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 8 ALA A 429
ASP A 430
ILE A 423
ILE A 390
ILE A 362
 ALA  A 429 ( 0.0A)
ASP  A 430 ( 0.5A)
ILE  A 423 ( 0.7A)
ILE  A 390 ( 0.7A)
ILE  A 362 ( 0.4A)
 1.18A 1sh9A-2nvvA:
undetectable		 1sh9A-2nvvA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 GLY A 141
GLY A  30
ASP A 381
GLY A 378
PRO A  82
 GLY  A 141 ( 0.0A)
GLY  A  30 ( 0.0A)
ASP  A 381 ( 0.6A)
GLY  A 378 ( 0.0A)
PRO  A  82 ( 1.1A)
 0.96A 1sqfA-2nvvA:
undetectable		 1sqfA-2nvvA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 11 THR A 392
LEU A 270
VAL A 266
GLY A 232
VAL A 428
 THR  A 392 ( 0.8A)
LEU  A 270 ( 0.6A)
VAL  A 266 ( 0.6A)
GLY  A 232 ( 0.0A)
VAL  A 428 ( 0.6A)
 1.25A 2a1nA-2nvvA:
undetectable		 2a1nA-2nvvA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 4 ILE A 248
ASP A 275
LEU A 270
ARG A 247
 ILE  A 248 ( 0.7A)
ASP  A 275 ( 0.5A)
LEU  A 270 ( 0.6A)
ARG  A 247 ( 0.6A)
 1.46A 2a7qA-2nvvA:
undetectable		 2a7qA-2nvvA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 7 ASP A 102
SER A  62
LEU A 105
GLU A 284
 ASP  A 102 ( 0.6A)
SER  A  62 ( 0.0A)
LEU  A 105 ( 0.6A)
GLU  A 284 ( 0.5A)
 1.10A 2cdqB-2nvvA:
undetectable		 2cdqB-2nvvA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		3 / 3 VAL A 262
VAL A 259
ASP A 413
 VAL  A 262 ( 0.6A)
VAL  A 259 ( 0.6A)
ASP  A 413 (-0.5A)
 0.78A 2fumD-2nvvA:
undetectable		 2fumD-2nvvA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 GLY A 143
GLY A 141
HIS A 171
ALA A  61
THR A  27
 GLY  A 143 ( 0.0A)
GLY  A 141 ( 0.0A)
HIS  A 171 ( 1.0A)
ALA  A  61 ( 0.0A)
THR  A  27 ( 0.8A)
 1.00A 2gluB-2nvvA:
undetectable		 2gluB-2nvvA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 6 PHE A 323
ARG A 298
GLY A 297
LYS A 296
 PHE  A 323 ( 1.3A)
ARG  A 298 ( 0.6A)
GLY  A 297 ( 0.0A)
LYS  A 296 ( 0.0A)
 1.14A 2i30A-2nvvA:
undetectable		 2i30A-2nvvA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		3 / 3 ASP A 413
THR A 393
PRO A 394
 ASP  A 413 (-0.5A)
THR  A 393 ( 0.8A)
PRO  A 394 ( 1.1A)
 0.61A 2pynB-2nvvA:
undetectable		 2pynB-2nvvA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		3 / 3 ASP A 473
ASN A 471
THR A 468
 ASP  A 473 ( 0.5A)
ASN  A 471 ( 0.6A)
THR  A 468 ( 0.8A)
 0.78A 2q63B-2nvvA:
undetectable		 2q63B-2nvvA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		3 / 3 ASP A 413
THR A 393
PRO A 394
 ASP  A 413 (-0.5A)
THR  A 393 ( 0.8A)
PRO  A 394 ( 1.1A)
 0.60A 2q64B-2nvvA:
undetectable		 2q64B-2nvvA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		3 / 3 ASP A 413
THR A 393
PRO A 394
 ASP  A 413 (-0.5A)
THR  A 393 ( 0.8A)
PRO  A 394 ( 1.1A)
 0.57A 2qakB-2nvvA:
undetectable		 2qakB-2nvvA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 VAL A 428
ILE A 350
LEU A 239
PHE A 238
SER A 386
 VAL  A 428 ( 0.6A)
ILE  A 350 ( 0.6A)
LEU  A 239 ( 0.6A)
PHE  A 238 ( 1.3A)
SER  A 386 ( 0.0A)
 1.11A 2w3vA-2nvvA:
undetectable		 2w3vA-2nvvA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.09A 2zj0A-2nvvA:
2.5		 2zj0A-2nvvA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 0.99A 2zj0B-2nvvA:
2.2		 2zj0B-2nvvA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.04A 2zj0C-2nvvA:
undetectable		 2zj0C-2nvvA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 11 GLY A 143
THR A  63
ARG A 113
PHE A  58
GLY A  22
 GLY  A 143 ( 0.0A)
THR  A  63 ( 0.8A)
ARG  A 113 ( 0.6A)
PHE  A  58 ( 1.3A)
GLY  A  22 ( 0.0A)
 0.95A 3ag1A-2nvvA:
0.0
3ag1B-2nvvA:
0.0
3ag1T-2nvvA:
0.0		 3ag1A-2nvvA:
22.39
3ag1B-2nvvA:
18.90
3ag1T-2nvvA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 6 MET A  57
ARG A  90
PRO A  32
GLY A  64
 VAL  A  77 ( 3.9A)
ARG  A  90 ( 0.6A)
PRO  A  32 ( 1.1A)
GLY  A  64 ( 0.0A)
 1.34A 3aqiA-2nvvA:
undetectable		 3aqiA-2nvvA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 8 HIS A 366
HIS A 411
ASP A 102
GLY A 375
 HIS  A 366 ( 1.0A)
HIS  A 411 (-1.0A)
ASP  A 102 ( 0.6A)
GLY  A 375 ( 0.0A)
 0.87A 3c0zB-2nvvA:
undetectable		 3c0zB-2nvvA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.10A 3ce6A-2nvvA:
2.6		 3ce6A-2nvvA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.09A 3ce6B-2nvvA:
undetectable		 3ce6B-2nvvA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.11A 3ce6C-2nvvA:
undetectable		 3ce6C-2nvvA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 ILE A 156
VAL A 207
ILE A   6
LEU A 159
VAL A  35
 ILE  A 156 ( 0.7A)
VAL  A 207 ( 0.6A)
ILE  A   6 ( 0.7A)
LEU  A 159 ( 0.6A)
VAL  A  35 ( 0.6A)
 0.98A 3fpjA-2nvvA:
undetectable		 3fpjA-2nvvA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 ILE A 156
VAL A 207
ILE A   6
LEU A 159
VAL A  35
 ILE  A 156 ( 0.7A)
VAL  A 207 ( 0.6A)
ILE  A   6 ( 0.7A)
LEU  A 159 ( 0.6A)
VAL  A  35 ( 0.6A)
 1.00A 3fpjB-2nvvA:
undetectable		 3fpjB-2nvvA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 4 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.07A 3g1uA-2nvvA:
undetectable		 3g1uA-2nvvA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.08A 3g1uC-2nvvA:
undetectable		 3g1uC-2nvvA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.06A 3glqA-2nvvA:
undetectable		 3glqA-2nvvA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.10A 3glqB-2nvvA:
undetectable		 3glqB-2nvvA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 GLY A 134
GLN A 200
VAL A 201
MET A 168
LEU A 137
 GLY  A 134 ( 0.0A)
GLN  A 200 ( 0.6A)
VAL  A 201 ( 0.6A)
PRO  A 197 ( 3.9A)
LEU  A 137 ( 0.6A)
 1.48A 3h52D-2nvvA:
undetectable		 3h52D-2nvvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 11 ASP A  88
ASN A  86
LEU A  89
VAL A  77
ALA A  76
 ASP  A  88 ( 0.5A)
ASN  A  86 ( 0.6A)
LEU  A  89 ( 0.6A)
VAL  A  77 ( 0.6A)
ALA  A  76 ( 0.0A)
 1.24A 3n23C-2nvvA:
undetectable		 3n23C-2nvvA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.09A 3n58A-2nvvA:
2.2		 3n58A-2nvvA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		3 / 3 TYR A 387
LEU A 185
ARG A 343
 TYR  A 387 ( 1.3A)
LEU  A 185 ( 0.6A)
ARG  A 343 ( 0.6A)
 0.78A 3sufB-2nvvA:
undetectable		 3sufB-2nvvA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		3 / 3 LEU A 330
HIS A 171
MET A 170
 LEU  A 330 ( 0.6A)
HIS  A 171 ( 1.0A)
ILE  A 167 ( 3.7A)
 0.90A 3thrD-2nvvA:
2.1		 3thrD-2nvvA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		3 / 3 ASP A 413
THR A 393
PRO A 394
 ASP  A 413 (-0.5A)
THR  A 393 ( 0.8A)
PRO  A 394 ( 1.1A)
 0.66A 3tkgD-2nvvA:
undetectable		 3tkgD-2nvvA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 ILE A 144
MET A  57
ASP A  19
VAL A  77
LEU A  71
 ILE  A 144 ( 0.7A)
VAL  A  77 ( 3.9A)
ASP  A  19 ( 0.6A)
VAL  A  77 ( 0.6A)
LEU  A  71 ( 0.6A)
 1.21A 3v8vA-2nvvA:
undetectable		 3v8vA-2nvvA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 ASN A  95
ASP A 413
ILE A 376
ASP A 102
HIS A 411
 ASN  A  95 ( 0.6A)
ASP  A 413 (-0.5A)
ILE  A 376 ( 0.7A)
ASP  A 102 ( 0.6A)
HIS  A 411 (-1.0A)
 1.29A 3w37A-2nvvA:
undetectable		 3w37A-2nvvA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 ASN A  95
ASP A 413
ILE A 376
ASP A 102
HIS A 411
 ASN  A  95 ( 0.6A)
ASP  A 413 (-0.5A)
ILE  A 376 ( 0.7A)
ASP  A 102 ( 0.6A)
HIS  A 411 (-1.0A)
 1.29A 3welA-2nvvA:
undetectable		 3welA-2nvvA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 LEU A 330
GLY A 304
ILE A 291
VAL A 290
 LEU  A 330 ( 0.6A)
GLY  A 304 ( 0.0A)
ILE  A 291 ( 0.7A)
VAL  A 290 ( 0.6A)
 0.66A 3wriA-2nvvA:
undetectable		 3wriA-2nvvA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 LEU A 330
GLY A 304
ILE A 291
VAL A 290
 LEU  A 330 ( 0.6A)
GLY  A 304 ( 0.0A)
ILE  A 291 ( 0.7A)
VAL  A 290 ( 0.6A)
 0.65A 3wriB-2nvvA:
undetectable		 3wriB-2nvvA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 LEU A 330
GLY A 304
ILE A 291
VAL A 290
 LEU  A 330 ( 0.6A)
GLY  A 304 ( 0.0A)
ILE  A 291 ( 0.7A)
VAL  A 290 ( 0.6A)
 0.77A 3wrkA-2nvvA:
undetectable		 3wrkA-2nvvA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 ILE A 314
LEU A 330
GLY A 304
ILE A 291
VAL A 290
 ILE  A 314 ( 0.4A)
LEU  A 330 ( 0.6A)
GLY  A 304 ( 0.0A)
ILE  A 291 ( 0.7A)
VAL  A 290 ( 0.6A)
 1.03A 4c9lA-2nvvA:
undetectable		 4c9lA-2nvvA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 ILE A 314
LEU A 330
GLY A 304
ILE A 291
VAL A 290
 ILE  A 314 ( 0.4A)
LEU  A 330 ( 0.6A)
GLY  A 304 ( 0.0A)
ILE  A 291 ( 0.7A)
VAL  A 290 ( 0.6A)
 1.02A 4c9lB-2nvvA:
undetectable		 4c9lB-2nvvA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 ILE A 314
LEU A 330
GLY A 304
ILE A 291
VAL A 290
 ILE  A 314 ( 0.4A)
LEU  A 330 ( 0.6A)
GLY  A 304 ( 0.0A)
ILE  A 291 ( 0.7A)
VAL  A 290 ( 0.6A)
 1.04A 4c9oA-2nvvA:
undetectable		 4c9oA-2nvvA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 ILE A 314
LEU A 330
GLY A 304
ILE A 291
VAL A 290
 ILE  A 314 ( 0.4A)
LEU  A 330 ( 0.6A)
GLY  A 304 ( 0.0A)
ILE  A 291 ( 0.7A)
VAL  A 290 ( 0.6A)
 1.05A 4c9oB-2nvvA:
undetectable		 4c9oB-2nvvA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		3 / 3 TYR A 282
ARG A 331
SER A 336
 TYR  A 282 ( 1.3A)
ARG  A 331 ( 0.6A)
SER  A 336 ( 0.0A)
 1.07A 4dr2I-2nvvA:
undetectable
4dr2J-2nvvA:
undetectable		 4dr2I-2nvvA:
14.83
4dr2J-2nvvA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 7 ALA A 289
VAL A 259
ILE A 314
THR A 283
 ALA  A 289 ( 0.0A)
VAL  A 259 ( 0.6A)
ILE  A 314 ( 0.4A)
THR  A 283 ( 0.8A)
 0.89A 4eyrA-2nvvA:
undetectable		 4eyrA-2nvvA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 LEU A 329
MET A 170
LEU A 330
ILE A 291
ILE A 317
 LEU  A 329 ( 0.6A)
ILE  A 167 ( 3.7A)
LEU  A 330 ( 0.6A)
ILE  A 291 ( 0.7A)
ILE  A 317 ( 0.7A)
 1.32A 4j24C-2nvvA:
undetectable		 4j24C-2nvvA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.02A 4lvcA-2nvvA:
2.4		 4lvcA-2nvvA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.02A 4lvcC-2nvvA:
2.0		 4lvcC-2nvvA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		3 / 3 LEU A 173
ARG A 331
MET A 281
 LEU  A 173 ( 0.6A)
ARG  A 331 ( 0.6A)
PHE  A 279 ( 3.6A)
 0.95A 4m11C-2nvvA:
undetectable		 4m11C-2nvvA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 6 TYR A 114
ARG A 150
GLU A 334
LEU A 177
 TYR  A 114 ( 1.3A)
ARG  A 150 ( 0.6A)
GLU  A 334 ( 0.6A)
LEU  A 177 ( 0.6A)
 1.37A 4twdF-2nvvA:
undetectable
4twdG-2nvvA:
undetectable		 4twdF-2nvvA:
21.66
4twdG-2nvvA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 10 ILE A 423
PHE A 391
GLY A 360
LEU A 431
ALA A 429
 ILE  A 423 ( 0.7A)
PHE  A 391 ( 1.3A)
GLY  A 360 ( 0.0A)
LEU  A 431 ( 0.6A)
ALA  A 429 ( 0.0A)
 1.41A 5ajqB-2nvvA:
undetectable		 5ajqB-2nvvA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_1
(ANTI-TICAGRELOR FAB
72, HEAVY CHAIN
ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 9 ILE A  93
THR A  98
TYR A 100
PRO A  82
ASP A 102
 ILE  A  93 ( 0.7A)
THR  A  98 ( 0.8A)
TYR  A 100 ( 1.3A)
PRO  A  82 ( 1.1A)
ASP  A 102 ( 0.6A)
 1.50A 5alcH-2nvvA:
0.0		 5alcH-2nvvA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 6 ASP A 172
TYR A 188
TYR A 282
LEU A 345
 ASP  A 172 ( 0.6A)
TYR  A 188 ( 1.3A)
TYR  A 282 ( 1.3A)
LEU  A 345 ( 0.6A)
 1.08A 5bmvB-2nvvA:
undetectable		 5bmvB-2nvvA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 GLY A  30
LEU A 307
LEU A  67
GLY A  60
GLY A 304
 GLY  A  30 ( 0.0A)
LEU  A 307 ( 0.6A)
LEU  A  67 ( 0.6A)
GLY  A  60 ( 0.0A)
GLY  A 304 ( 0.0A)
 0.92A 5d4uA-2nvvA:
2.4		 5d4uA-2nvvA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 GLY A  30
LEU A 307
LEU A  67
GLY A  60
GLY A 304
 GLY  A  30 ( 0.0A)
LEU  A 307 ( 0.6A)
LEU  A  67 ( 0.6A)
GLY  A  60 ( 0.0A)
GLY  A 304 ( 0.0A)
 0.87A 5d4uB-2nvvA:
2.6		 5d4uB-2nvvA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 GLY A  30
LEU A 307
LEU A  67
GLY A  60
GLY A 304
 GLY  A  30 ( 0.0A)
LEU  A 307 ( 0.6A)
LEU  A  67 ( 0.6A)
GLY  A  60 ( 0.0A)
GLY  A 304 ( 0.0A)
 0.87A 5d4uC-2nvvA:
2.3		 5d4uC-2nvvA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 GLY A  30
LEU A 307
LEU A  67
GLY A  60
GLY A 304
 GLY  A  30 ( 0.0A)
LEU  A 307 ( 0.6A)
LEU  A  67 ( 0.6A)
GLY  A  60 ( 0.0A)
GLY  A 304 ( 0.0A)
 0.95A 5d4uD-2nvvA:
2.5		 5d4uD-2nvvA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 PRO A  36
GLY A  22
PHE A  23
ASP A  68
LEU A  71
 PRO  A  36 ( 1.1A)
GLY  A  22 ( 0.0A)
PHE  A  23 ( 1.3A)
ASP  A  68 ( 0.5A)
LEU  A  71 ( 0.6A)
 1.24A 5eeiA-2nvvA:
undetectable		 5eeiA-2nvvA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 PRO A  36
GLY A  22
PHE A  23
ASP A  68
LEU A  71
 PRO  A  36 ( 1.1A)
GLY  A  22 ( 0.0A)
PHE  A  23 ( 1.3A)
ASP  A  68 ( 0.5A)
LEU  A  71 ( 0.6A)
 1.23A 5eeiB-2nvvA:
2.1		 5eeiB-2nvvA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 ILE A 358
PRO A 469
LEU A 460
PHE A 359
HIS A 417
 ILE  A 358 ( 0.7A)
PRO  A 469 ( 1.1A)
LEU  A 460 ( 0.6A)
PHE  A 359 ( 1.3A)
HIS  A 417 (-1.0A)
 1.34A 5k7uA-2nvvA:
undetectable		 5k7uA-2nvvA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 VAL A 406
ASP A 357
HIS A 479
LEU A 482
LEU A 354
 VAL  A 406 ( 0.6A)
ASP  A 357 ( 0.6A)
HIS  A 479 ( 1.0A)
LEU  A 482 ( 0.6A)
LEU  A 354 ( 0.6A)
 1.14A 5nd7B-2nvvA:
undetectable		 5nd7B-2nvvA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		3 / 3 VAL A 491
LYS A 401
MET A 397
 VAL  A 491 ( 0.6A)
LYS  A 401 ( 0.0A)
ILE  A 402 ( 3.8A)
 1.10A 5nknA-2nvvA:
undetectable		 5nknA-2nvvA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 LEU A 145
VAL A 199
PRO A 138
THR A 139
GLU A 126
 LEU  A 145 ( 0.6A)
VAL  A 199 ( 0.6A)
PRO  A 138 ( 1.1A)
THR  A 139 ( 0.8A)
GLU  A 126 ( 0.5A)
 1.39A 5xipD-2nvvA:
undetectable		 5xipD-2nvvA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		3 / 3 LYS A  33
ASN A  31
SER A  24
 LYS  A  33 ( 0.0A)
ASN  A  31 ( 0.6A)
SER  A  24 ( 0.0A)
 1.17A 5yw0A-2nvvA:
undetectable		 5yw0A-2nvvA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 10 TYR A 335
LEU A 173
ASP A 172
VAL A 142
GLY A 143
 TYR  A 335 ( 1.3A)
LEU  A 173 ( 0.6A)
ASP  A 172 ( 0.6A)
VAL  A 142 ( 0.6A)
GLY  A 143 ( 0.0A)
 1.47A 5zbdA-2nvvA:
0.0		 5zbdA-2nvvA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_B_TRPB501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 10 TYR A 335
LEU A 173
ASP A 172
VAL A 142
GLY A 143
 TYR  A 335 ( 1.3A)
LEU  A 173 ( 0.6A)
ASP  A 172 ( 0.6A)
VAL  A 142 ( 0.6A)
GLY  A 143 ( 0.0A)
 1.43A 5zbdB-2nvvA:
0.0		 5zbdB-2nvvA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		3 / 3 ASN A  51
VAL A  15
HIS A  16
 ASN  A  51 ( 0.6A)
VAL  A  15 ( 0.6A)
HIS  A  16 ( 1.0A)
 0.83A 6a5yD-2nvvA:
undetectable		 6a5yD-2nvvA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.05A 6aphA-2nvvA:
undetectable		 6aphA-2nvvA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 9 ALA A  61
SER A  62
VAL A 285
VAL A 259
GLY A 378
 ALA  A  61 ( 0.0A)
SER  A  62 ( 0.0A)
VAL  A 285 ( 0.6A)
VAL  A 259 ( 0.6A)
GLY  A 378 ( 0.0A)
 1.02A 6bklA-2nvvA:
undetectable
6bklB-2nvvA:
undetectable
6bklC-2nvvA:
undetectable
6bklD-2nvvA:
undetectable		 6bklA-2nvvA:
11.88
6bklB-2nvvA:
11.88
6bklC-2nvvA:
11.88
6bklD-2nvvA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 9 SER A  62
ALA A  29
VAL A 285
SER A 306
GLY A 141
 SER  A  62 ( 0.0A)
ALA  A  29 ( 0.0A)
VAL  A 285 ( 0.6A)
SER  A 306 ( 0.0A)
GLY  A 141 ( 0.0A)
 1.24A 6bklA-2nvvA:
undetectable
6bklB-2nvvA:
undetectable
6bklC-2nvvA:
undetectable
6bklD-2nvvA:
undetectable		 6bklA-2nvvA:
11.88
6bklB-2nvvA:
11.88
6bklC-2nvvA:
11.88
6bklD-2nvvA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 9 SER A  62
ALA A  29
VAL A 285
SER A 306
GLY A 143
 SER  A  62 ( 0.0A)
ALA  A  29 ( 0.0A)
VAL  A 285 ( 0.6A)
SER  A 306 ( 0.0A)
GLY  A 143 ( 0.0A)
 1.22A 6bklA-2nvvA:
undetectable
6bklB-2nvvA:
undetectable
6bklC-2nvvA:
undetectable
6bklD-2nvvA:
undetectable		 6bklA-2nvvA:
11.88
6bklB-2nvvA:
11.88
6bklC-2nvvA:
11.88
6bklD-2nvvA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 9 ALA A  29
GLY A 141
ALA A  61
GLY A 143
SER A  62
 ALA  A  29 ( 0.0A)
GLY  A 141 ( 0.0A)
ALA  A  61 ( 0.0A)
GLY  A 143 ( 0.0A)
SER  A  62 ( 0.0A)
 1.09A 6bklE-2nvvA:
undetectable
6bklF-2nvvA:
undetectable
6bklG-2nvvA:
undetectable
6bklH-2nvvA:
undetectable		 6bklE-2nvvA:
11.88
6bklF-2nvvA:
11.88
6bklG-2nvvA:
11.88
6bklH-2nvvA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 9 ALA A  29
SER A 306
GLY A 141
GLY A 143
SER A  62
 ALA  A  29 ( 0.0A)
SER  A 306 ( 0.0A)
GLY  A 141 ( 0.0A)
GLY  A 143 ( 0.0A)
SER  A  62 ( 0.0A)
 1.18A 6bklE-2nvvA:
undetectable
6bklF-2nvvA:
undetectable
6bklG-2nvvA:
undetectable
6bklH-2nvvA:
undetectable		 6bklE-2nvvA:
11.88
6bklF-2nvvA:
11.88
6bklG-2nvvA:
11.88
6bklH-2nvvA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 11 ASP A 178
PRO A 176
ARG A 182
PRO A  82
TYR A 117
 ASP  A 178 ( 0.6A)
PRO  A 176 ( 1.1A)
ARG  A 182 ( 0.6A)
PRO  A  82 ( 1.1A)
TYR  A 117 ( 1.3A)
 1.27A 6bm5A-2nvvA:
undetectable		 6bm5A-2nvvA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 7 ILE A 286
GLN A 287
VAL A 309
ILE A 317
 ILE  A 286 ( 0.7A)
GLN  A 287 ( 0.6A)
VAL  A 309 ( 0.6A)
ILE  A 317 ( 0.7A)
 0.98A 6cduF-2nvvA:
undetectable
6cduG-2nvvA:
undetectable		 6cduF-2nvvA:
23.26
6cduG-2nvvA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_A_ADNA505_2
(-)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 4 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.07A 6f3nA-2nvvA:
0.6		 6f3nA-2nvvA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_C_ADNC505_2
(-)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 4 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.07A 6f3nC-2nvvA:
undetectable		 6f3nC-2nvvA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_D_ADND506_2
(-)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 4 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.07A 6f3nD-2nvvA:
undetectable		 6f3nD-2nvvA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.02A 6gbnA-2nvvA:
undetectable		 6gbnA-2nvvA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.03A 6gbnB-2nvvA:
undetectable		 6gbnB-2nvvA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.02A 6gbnC-2nvvA:
undetectable		 6gbnC-2nvvA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.03A 6gbnD-2nvvA:
undetectable		 6gbnD-2nvvA:
23.48