SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nwb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		4 / 4 THR A 320
LEU A 194
VAL A 313
LEU A 187
 None
 0.98A 1fbmB-2nwbA:
undetectable		 1fbmB-2nwbA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		4 / 6 ASN A 235
ALA A 234
GLY A 233
TYR A 221
 HEM  A 401 (-2.6A)
None
None
None
 1.09A 1l5qA-2nwbA:
undetectable		 1l5qA-2nwbA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		4 / 6 ASN A 235
ALA A 234
GLY A 233
TYR A 221
 HEM  A 401 (-2.6A)
None
None
None
 1.11A 1l5qB-2nwbA:
undetectable		 1l5qB-2nwbA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		4 / 6 ASN A 235
ALA A 234
GLY A 233
TYR A 221
 HEM  A 401 (-2.6A)
None
None
None
 1.10A 1l7xA-2nwbA:
undetectable		 1l7xA-2nwbA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		4 / 6 ASN A 235
ALA A 234
GLY A 233
TYR A 221
 HEM  A 401 (-2.6A)
None
None
None
 1.07A 1l7xB-2nwbA:
undetectable		 1l7xB-2nwbA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		5 / 12 ASN A  80
VAL A  81
TYR A 224
ASN A  23
LEU A  22
 None
 1.14A 2iyfB-2nwbA:
undetectable		 2iyfB-2nwbA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		5 / 12 ASN A  80
HIS A 128
ILE A 160
ASN A 156
PHE A 152
 None
None
HEM  A 401 ( 4.8A)
HEM  A 401 (-4.2A)
HEM  A 401 (-4.8A)
 1.40A 3a25A-2nwbA:
undetectable		 3a25A-2nwbA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		4 / 5 ASN A 235
ALA A 234
GLY A 233
TYR A 221
 HEM  A 401 (-2.6A)
None
None
None
 1.12A 3bcrA-2nwbA:
undetectable		 3bcrA-2nwbA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		4 / 6 ASN A 235
ALA A 234
GLY A 233
TYR A 221
 HEM  A 401 (-2.6A)
None
None
None
 1.09A 3dd1A-2nwbA:
undetectable		 3dd1A-2nwbA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		4 / 6 ASN A 235
ALA A 234
GLY A 233
TYR A 221
 HEM  A 401 (-2.6A)
None
None
None
 1.10A 3dd1B-2nwbA:
undetectable		 3dd1B-2nwbA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		4 / 6 ASN A 235
ALA A 234
GLY A 233
TYR A 221
 HEM  A 401 (-2.6A)
None
None
None
 1.10A 3ddsA-2nwbA:
undetectable		 3ddsA-2nwbA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		4 / 6 ASN A 235
ALA A 234
GLY A 233
TYR A 221
 HEM  A 401 (-2.6A)
None
None
None
 1.09A 3ddsB-2nwbA:
undetectable		 3ddsB-2nwbA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		4 / 6 ASN A 235
ALA A 234
GLY A 233
TYR A 221
 HEM  A 401 (-2.6A)
None
None
None
 1.09A 3ddwA-2nwbA:
0.6		 3ddwA-2nwbA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		4 / 6 ASN A 235
ALA A 234
GLY A 233
TYR A 221
 HEM  A 401 (-2.6A)
None
None
None
 1.09A 3ddwB-2nwbA:
undetectable		 3ddwB-2nwbA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		5 / 12 HIS A 113
VAL A  58
LEU A  61
ILE A 114
GLY A  79
 None
 1.00A 3kk6B-2nwbA:
undetectable		 3kk6B-2nwbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		4 / 7 PRO A 219
LEU A 208
TYR A 221
ASN A 156
 None
None
None
HEM  A 401 (-4.2A)
 0.95A 3p50A-2nwbA:
2.7		 3p50A-2nwbA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		4 / 7 PRO A 219
LEU A 208
TYR A 221
ASN A 156
 None
None
None
HEM  A 401 (-4.2A)
 0.96A 3p50B-2nwbA:
2.8		 3p50B-2nwbA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		4 / 7 PRO A 219
LEU A 208
TYR A 221
ASN A 156
 None
None
None
HEM  A 401 (-4.2A)
 0.96A 3p50C-2nwbA:
3.2		 3p50C-2nwbA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		4 / 7 PRO A 219
LEU A 208
TYR A 221
ASN A 156
 None
None
None
HEM  A 401 (-4.2A)
 0.96A 3p50D-2nwbA:
3.1		 3p50D-2nwbA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		4 / 7 PRO A 219
LEU A 208
TYR A 221
ASN A 156
 None
None
None
HEM  A 401 (-4.2A)
 0.97A 3p50E-2nwbA:
3.1		 3p50E-2nwbA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		4 / 5 ARG A 368
ARG A 369
ILE A 377
ARG A 374
 None
HEM  A 401 (-2.2A)
None
None
 1.45A 3ticA-2nwbA:
undetectable		 3ticA-2nwbA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		4 / 8 ASN A 243
ASP A 246
LEU A 365
HIS A 317
 HEM  A 401 ( 4.5A)
None
HEM  A 401 (-3.7A)
None
 1.21A 4f5zA-2nwbA:
undetectable		 4f5zA-2nwbA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		3 / 3 ASP A 148
ARG A 212
ASP A 145
 None
 0.87A 4fp9D-2nwbA:
undetectable		 4fp9D-2nwbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		4 / 8 THR A 190
ILE A 242
LEU A 287
LEU A 251
 None
HEM  A 401 (-3.7A)
None
None
 0.96A 4r38B-2nwbA:
undetectable		 4r38B-2nwbA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		4 / 4 ALA A 166
VAL A 313
GLY A 318
THR A 320
 None
 1.14A 4ubeA-2nwbA:
undetectable		 4ubeA-2nwbA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_2
(NEURAMINIDASE)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		4 / 5 ARG A 368
ARG A 369
ILE A 377
ARG A 374
 None
HEM  A 401 (-2.2A)
None
None
 1.20A 4wa5A-2nwbA:
undetectable		 4wa5A-2nwbA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_A_FOLA201_0
(FOLATE ECF
TRANSPORTER)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		5 / 12 LEU A 151
ALA A 236
TYR A 163
THR A 320
ASN A 206
 None
HEM  A 401 (-3.4A)
HEM  A 401 ( 4.8A)
None
None
 1.35A 4z7fA-2nwbA:
0.7		 4z7fA-2nwbA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		4 / 4 VAL A 226
GLY A 227
ARG A 225
VAL A 230
 None
 1.34A 5d4nA-2nwbA:
undetectable
5d4nB-2nwbA:
undetectable		 5d4nA-2nwbA:
14.44
5d4nB-2nwbA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		5 / 12 ILE A 245
TYR A 163
GLU A 315
ALA A 162
PHE A 310
 None
HEM  A 401 ( 4.8A)
None
None
None
 1.30A 5iwuA-2nwbA:
undetectable		 5iwuA-2nwbA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2nwb CONSERVED DOMAIN
PROTEIN
(Shewanella
oneidensis) 		4 / 5 PHE A 152
THR A 157
GLU A 149
ASN A  23
 HEM  A 401 (-4.8A)
None
None
None
 1.30A 5ybbA-2nwbA:
undetectable		 5ybbA-2nwbA:
22.58