SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nwq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 4 ARG A  20
ALA A  19
ALA A  43
GLU A  45
 None
 1.22A 1e7bA-2nwqA:
undetectable		 1e7bA-2nwqA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 8 ALA A  19
LEU A  39
LEU A  31
LEU A  46
ALA A  43
 None
 1.40A 1e7cA-2nwqA:
undetectable		 1e7cA-2nwqA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 166
PHE A 162
VAL A  69
LEU A 125
MET A  65
 None
 1.36A 1mx1B-2nwqA:
3.8		 1mx1B-2nwqA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  31
LEU A  39
GLY A  33
MET A  65
ILE A  83
 None
None
SO4  A 254 (-3.4A)
None
None
 1.47A 1p93A-2nwqA:
undetectable		 1p93A-2nwqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  42
GLY A  33
LEU A  46
LEU A  29
ALA A  19
 None
SO4  A 254 (-3.4A)
None
None
None
 1.02A 2egvB-2nwqA:
3.7		 2egvB-2nwqA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A  89
VAL A 151
TRP A 103
 None
 0.99A 2izqA-2nwqA:
undetectable
2izqB-2nwqA:
undetectable		 2izqA-2nwqA:
3.98
2izqB-2nwqA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  80
VAL A  52
THR A  50
 None
 0.79A 2nnkA-2nwqA:
undetectable		 2nnkA-2nwqA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 10 ILE A   7
ASN A  85
ALA A  86
VAL A  30
LEU A  39
 None
 1.31A 3ay0A-2nwqA:
6.4		 3ay0A-2nwqA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 4 LEU A  39
PRO A  54
LEU A  31
ARG A  20
 None
 1.39A 3hcoA-2nwqA:
3.3		 3hcoA-2nwqA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ASN A 231
GLY A  81
THR A   4
ILE A 134
LEU A 125
 None
 1.14A 3iv6A-2nwqA:
5.5		 3iv6A-2nwqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  80
VAL A  52
THR A  50
 None
 0.79A 3k4vA-2nwqA:
undetectable		 3k4vA-2nwqA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  80
VAL A  52
THR A  50
 None
 0.76A 3k4vD-2nwqA:
undetectable		 3k4vD-2nwqA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  80
VAL A  52
THR A  50
 None
 0.73A 3nduD-2nwqA:
undetectable		 3nduD-2nwqA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  80
VAL A  52
THR A  50
 None
 0.78A 3pwrA-2nwqA:
undetectable		 3pwrA-2nwqA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  80
VAL A  52
THR A  50
 None
 0.78A 3tl9A-2nwqA:
undetectable		 3tl9A-2nwqA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 10 ILE A 126
LEU A 122
THR A 173
GLY A 174
GLY A 131
 None
 1.26A 4bwlC-2nwqA:
2.4		 4bwlC-2nwqA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 122
PRO A 123
LEU A 125
ILE A 134
 None
 0.92A 4klrA-2nwqA:
3.2		 4klrA-2nwqA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A  20
ALA A  19
LEU A  31
SER A  47
 None
 1.11A 4ot2A-2nwqA:
undetectable		 4ot2A-2nwqA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A  82
LEU A 115
PHE A 162
VAL A 177
 None
 0.95A 4udaA-2nwqA:
undetectable		 4udaA-2nwqA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  46
GLY A  15
GLY A   9
LEU A 137
ARG A  20
 None
None
SO4  A 254 (-3.1A)
None
None
 1.29A 4x61A-2nwqA:
3.9		 4x61A-2nwqA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  33
LEU A  42
GLY A  15
GLY A 113
PHE A   6
 SO4  A 254 (-3.4A)
None
None
None
None
 1.03A 5d4uB-2nwqA:
6.3		 5d4uB-2nwqA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A  26
THR A  50
GLN A 226
LEU A   5
LEU A  29
 None
 1.18A 5fhzB-2nwqA:
4.1		 5fhzB-2nwqA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  26
THR A  50
GLN A 226
LEU A   5
LEU A  29
 None
 1.17A 5fhzC-2nwqA:
4.2		 5fhzC-2nwqA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A  68
ASN A  71
LEU A  72
 None
 0.26A 5i1nC-2nwqA:
undetectable		 5i1nC-2nwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A  68
ASN A  71
LEU A  72
 None
 0.25A 5i1oC-2nwqA:
undetectable		 5i1oC-2nwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A  68
ASN A  71
LEU A  72
 None
 0.35A 5i1pA-2nwqA:
undetectable		 5i1pA-2nwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A  68
ASN A  71
LEU A  72
 None
 0.25A 5i1pD-2nwqA:
undetectable		 5i1pD-2nwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  42
GLY A  33
LEU A  46
LEU A  29
ALA A  19
 None
SO4  A 254 (-3.4A)
None
None
None
 0.99A 5o96G-2nwqA:
3.2
5o96H-2nwqA:
3.3		 5o96G-2nwqA:
21.68
5o96H-2nwqA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 ASN A  85
ILE A 211
LEU A 137
PRO A 213
 None
 1.00A 5u4sB-2nwqA:
25.2		 5u4sB-2nwqA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 THR A   4
PHE A   6
LEU A 121
SER A  66
 None
 1.21A 5uxcA-2nwqA:
undetectable		 5uxcA-2nwqA:
24.12