SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nx4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 2nx4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY PROTEIN
(Rhodococcus
jostii) 		5 / 12 TYR A  61
ILE A 105
ILE A  22
GLU A  98
THR A  15
 None
 1.30A 1jtxA-2nx4A:
14.9		 1jtxA-2nx4A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 2nx4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY PROTEIN
(Rhodococcus
jostii) 		5 / 12 LEU A  82
LEU A  85
GLN A 133
LEU A 186
MET A 163
 None
 1.39A 1sqnA-2nx4A:
undetectable		 1sqnA-2nx4A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 2nx4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY PROTEIN
(Rhodococcus
jostii) 		5 / 12 LEU A  82
LEU A  85
LEU A  88
MET A 163
LEU A 193
 None
 1.17A 1zucB-2nx4A:
undetectable		 1zucB-2nx4A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 2nx4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY PROTEIN
(Rhodococcus
jostii) 		4 / 8 ASP A  34
PHE A  50
ASP A  54
THR A  59
 None
 0.96A 2aouA-2nx4A:
undetectable		 2aouA-2nx4A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 2nx4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY PROTEIN
(Rhodococcus
jostii) 		5 / 12 LEU A  82
LEU A  85
LEU A  88
MET A 162
MET A 163
 None
 1.40A 3d90A-2nx4A:
undetectable		 3d90A-2nx4A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2nx4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY PROTEIN
(Rhodococcus
jostii) 		5 / 11 ILE A 136
LEU A  85
PHE A 137
ILE A  72
LEU A  76
 None
 1.05A 4qlfA-2nx4A:
undetectable		 4qlfA-2nx4A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2nx4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY PROTEIN
(Rhodococcus
jostii) 		5 / 12 ILE A 136
LEU A  85
PHE A 137
ILE A  72
LEU A  76
 None
 1.05A 4qlgB-2nx4A:
undetectable		 4qlgB-2nx4A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 2nx4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY PROTEIN
(Rhodococcus
jostii) 		4 / 6 LEU A 186
LEU A 183
ILE A  95
MET A  93
 None
 0.90A 4ww7A-2nx4A:
undetectable		 4ww7A-2nx4A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2nx4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY PROTEIN
(Rhodococcus
jostii) 		5 / 12 ILE A 136
LEU A  85
PHE A 137
ILE A  72
LEU A  76
 None
 1.05A 4x5gA-2nx4A:
undetectable		 4x5gA-2nx4A:
23.04