SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nx8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 2nx8 TRNA-SPECIFIC
ADENOSINE DEAMINASE
(Streptococcus
pyogenes) 		5 / 8 ALA A 146
ASP A 148
ILE A  92
ILE A 111
PRO A  94
 None
 1.43A 1sh9A-2nx8A:
undetectable		 1sh9A-2nx8A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2nx8 TRNA-SPECIFIC
ADENOSINE DEAMINASE
(Streptococcus
pyogenes) 		4 / 8 LEU A 144
GLU A 141
THR A  87
VAL A  43
 None
 0.92A 4iizB-2nx8A:
undetectable		 4iizB-2nx8A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 2nx8 TRNA-SPECIFIC
ADENOSINE DEAMINASE
(Streptococcus
pyogenes) 		4 / 8 LEU A 144
GLU A 141
THR A  87
VAL A  43
 None
 0.91A 4ik6B-2nx8A:
undetectable		 4ik6B-2nx8A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2nx8 TRNA-SPECIFIC
ADENOSINE DEAMINASE
(Streptococcus
pyogenes) 		3 / 3 LEU A  84
LEU A 129
ASN A 135
 None
 0.73A 4otwA-2nx8A:
undetectable		 4otwA-2nx8A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2nx8 TRNA-SPECIFIC
ADENOSINE DEAMINASE
(Streptococcus
pyogenes) 		5 / 9 ILE A 111
VAL A 110
GLY A 113
ALA A 114
SER A 124
 None
 1.01A 4r21B-2nx8A:
undetectable		 4r21B-2nx8A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 2nx8 TRNA-SPECIFIC
ADENOSINE DEAMINASE
(Streptococcus
pyogenes) 		4 / 5 LEU A  88
ALA A 101
VAL A 122
ILE A 128
 None
 0.98A 4xe3A-2nx8A:
undetectable		 4xe3A-2nx8A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2nx8 TRNA-SPECIFIC
ADENOSINE DEAMINASE
(Streptococcus
pyogenes) 		5 / 12 HIS A  77
GLY A  79
ASN A  80
GLU A  26
ALA A 105
 None
 1.20A 5ih0A-2nx8A:
undetectable		 5ih0A-2nx8A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2nx8 TRNA-SPECIFIC
ADENOSINE DEAMINASE
(Streptococcus
pyogenes) 		5 / 11 ASP A 123
TYR A 112
VAL A  90
GLY A  39
ASN A 116
 None
 1.17A 6hu9A-2nx8A:
0.8
6hu9E-2nx8A:
0.0
6hu9I-2nx8A:
undetectable		 6hu9A-2nx8A:
17.44
6hu9E-2nx8A:
22.22
6hu9I-2nx8A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2nx8 TRNA-SPECIFIC
ADENOSINE DEAMINASE
(Streptococcus
pyogenes) 		5 / 11 SER A 124
TYR A 112
VAL A  90
GLY A  39
SER A  30
 None
 1.32A 6hu9A-2nx8A:
0.8
6hu9E-2nx8A:
0.0
6hu9I-2nx8A:
undetectable		 6hu9A-2nx8A:
17.44
6hu9E-2nx8A:
22.22
6hu9I-2nx8A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2nx8 TRNA-SPECIFIC
ADENOSINE DEAMINASE
(Streptococcus
pyogenes) 		5 / 10 ASP A 123
TYR A 112
VAL A  90
GLY A  39
ASN A 116
 None
 1.17A 6hu9L-2nx8A:
undetectable
6hu9P-2nx8A:
undetectable
6hu9T-2nx8A:
undetectable		 6hu9L-2nx8A:
17.44
6hu9P-2nx8A:
22.22
6hu9T-2nx8A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2nx8 TRNA-SPECIFIC
ADENOSINE DEAMINASE
(Streptococcus
pyogenes) 		5 / 10 SER A 124
TYR A 112
VAL A  90
GLY A  39
SER A  30
 None
 1.27A 6hu9L-2nx8A:
undetectable
6hu9P-2nx8A:
undetectable
6hu9T-2nx8A:
undetectable		 6hu9L-2nx8A:
17.44
6hu9P-2nx8A:
22.22
6hu9T-2nx8A:
17.32