SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nx9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMY_A_AZMA400_1
(MURINE CARBONIC
ANHYDRASE V)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		5 / 11 VAL A   8
LEU A 253
LEU A 249
THR A 246
THR A 232
 None
 1.31A 1dmyA-2nx9A:
undetectable		 1dmyA-2nx9A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		4 / 7 HIS A 209
LEU A  22
SER A  21
ASP A  17
 ZN  A 601 (-3.4A)
None
None
ZN  A 601 (-2.6A)
 1.14A 1ismB-2nx9A:
undetectable		 1ismB-2nx9A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		4 / 8 VAL A  13
ARG A 275
GLU A 247
ASP A  12
 None
 1.20A 1s3zA-2nx9A:
undetectable
1s3zB-2nx9A:
0.8		 1s3zA-2nx9A:
17.14
1s3zB-2nx9A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_C_T44C601_1
(TRANSTHYRETIN)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		5 / 9 LEU A  86
LEU A  92
LEU A 438
GLU A 107
ALA A 109
 None
 1.20A 1sn0A-2nx9A:
undetectable
1sn0C-2nx9A:
undetectable		 1sn0A-2nx9A:
15.30
1sn0C-2nx9A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		3 / 3 ASP A  65
PHE A 450
ARG A 454
 None
 0.84A 2a3aA-2nx9A:
10.4		 2a3aA-2nx9A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		5 / 10 ASP A  12
LEU A  47
VAL A  14
PHE A 274
THR A 246
 None
 1.10A 2w9hA-2nx9A:
undetectable		 2w9hA-2nx9A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		5 / 12 LEU A  91
LEU A 442
ALA A  98
ALA A 441
VAL A 437
 None
 1.04A 3b0wA-2nx9A:
undetectable		 3b0wA-2nx9A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		3 / 3 TYR A 241
GLU A 309
ASP A 322
 None
 0.68A 3bxoA-2nx9A:
undetectable		 3bxoA-2nx9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		3 / 3 TYR A 241
GLU A 309
ASP A 322
 None
 0.77A 3bxoB-2nx9A:
undetectable		 3bxoB-2nx9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		4 / 6 GLN A  83
HIS A 243
ARG A 118
HIS A 207
 None
None
None
ZN  A 601 (-3.4A)
 1.20A 3nvcA-2nx9A:
undetectable		 3nvcA-2nx9A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		5 / 12 GLY A 242
ASP A  17
ARG A  87
GLY A 182
SER A 345
 None
ZN  A 601 (-2.6A)
None
None
None
 1.24A 3sueD-2nx9A:
undetectable		 3sueD-2nx9A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		5 / 12 LEU A  85
ARG A 118
HIS A 207
HIS A 209
SER A  21
 None
None
ZN  A 601 (-3.4A)
ZN  A 601 (-3.4A)
None
 1.33A 4aqlA-2nx9A:
3.8		 4aqlA-2nx9A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		5 / 12 LEU A  85
HIS A 207
ALA A 122
HIS A 209
SER A  21
 None
ZN  A 601 (-3.4A)
None
ZN  A 601 (-3.4A)
None
 1.28A 4aqlA-2nx9A:
3.8		 4aqlA-2nx9A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		5 / 12 LEU A  85
THR A 146
GLU A  48
ASP A 231
HIS A 205
 None
 1.22A 4lvcC-2nx9A:
2.0		 4lvcC-2nx9A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		4 / 6 ASP A  17
LEU A  22
HIS A 209
THR A 211
 ZN  A 601 (-2.6A)
None
ZN  A 601 (-3.4A)
None
 1.19A 4paeA-2nx9A:
undetectable		 4paeA-2nx9A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		3 / 3 TYR A 258
THR A 260
THR A 256
 None
 0.75A 5aoxB-2nx9A:
undetectable		 5aoxB-2nx9A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		4 / 5 HIS A 243
HIS A 207
VAL A  13
ALA A  18
 None
ZN  A 601 (-3.4A)
None
None
 1.27A 5i3bB-2nx9A:
undetectable		 5i3bB-2nx9A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		5 / 12 ILE A 328
ARG A 332
PRO A 301
LEU A 340
GLU A 309
 None
 1.17A 5il1A-2nx9A:
undetectable		 5il1A-2nx9A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		4 / 5 SER A 194
VAL A 193
GLY A 226
ALA A 225
 None
 0.94A 5k50A-2nx9A:
undetectable		 5k50A-2nx9A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		5 / 12 ILE A 328
ARG A 332
PRO A 301
LEU A 340
GLU A 309
 None
 1.27A 5k7uA-2nx9A:
undetectable		 5k7uA-2nx9A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		4 / 6 GLN A  83
PHE A 117
LEU A  92
PHE A  55
 None
 1.13A 5z85P-2nx9A:
undetectable
5z85W-2nx9A:
undetectable		 5z85P-2nx9A:
18.63
5z85W-2nx9A:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		5 / 12 LEU A  85
THR A 146
GLU A  48
ASP A 231
HIS A 205
 None
 1.25A 6aphA-2nx9A:
undetectable		 6aphA-2nx9A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		3 / 3 LEU A  92
ASP A 436
ILE A 434
 None
 0.53A 6dh0B-2nx9A:
undetectable		 6dh0B-2nx9A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		5 / 12 TYR A  44
LEU A  47
ILE A 270
VAL A 277
THR A 246
 None
 1.17A 6djzB-2nx9A:
undetectable		 6djzB-2nx9A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		5 / 12 TYR A  44
LEU A  47
SER A 236
ILE A 270
THR A 246
 None
 1.34A 6djzB-2nx9A:
undetectable		 6djzB-2nx9A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		5 / 10 GLY A 302
GLY A 303
ILE A 295
HIS A 209
GLY A 182
 None
None
None
ZN  A 601 (-3.4A)
None
 1.04A 6e5zA-2nx9A:
undetectable		 6e5zA-2nx9A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		3 / 3 LEU A 325
LEU A 305
ARG A 294
 None
 0.54A 6fgcA-2nx9A:
undetectable		 6fgcA-2nx9A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		3 / 3 LEU A 325
LEU A 305
ARG A 294
 None
 0.55A 6fgdA-2nx9A:
undetectable		 6fgdA-2nx9A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		4 / 8 ASP A  56
ILE A  59
ARG A  60
ASN A 453
 None
 1.25A 6hisC-2nx9A:
undetectable
6hisD-2nx9A:
undetectable		 6hisC-2nx9A:
10.07
6hisD-2nx9A:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		4 / 8 ASN A 453
ASP A  56
ILE A  59
ARG A  60
 None
 1.26A 6hisA-2nx9A:
undetectable
6hisE-2nx9A:
undetectable		 6hisA-2nx9A:
10.07
6hisE-2nx9A:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA
(Vibrio
cholerae) 		4 / 6 GLN A  83
PHE A 117
LEU A  92
PHE A  55
 None
 1.01A 6nmpC-2nx9A:
undetectable
6nmpJ-2nx9A:
undetectable		 6nmpC-2nx9A:
18.63
6nmpJ-2nx9A:
7.54