SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nxf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 8 ASP A 151
GLY A 200
GLY A 199
GLN A 205
 None
 0.79A 1ekjA-2nxfA:
undetectable
1ekjB-2nxfA:
undetectable		 1ekjA-2nxfA:
21.65
1ekjB-2nxfA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 ASP A 151
GLY A 200
GLY A 199
GLN A 205
 None
 0.78A 1ekjE-2nxfA:
undetectable
1ekjF-2nxfA:
undetectable		 1ekjE-2nxfA:
21.65
1ekjF-2nxfA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 8 GLN A 205
ASP A 151
GLY A 200
GLY A 199
 None
 0.81A 1ekjE-2nxfA:
undetectable
1ekjF-2nxfA:
undetectable		 1ekjE-2nxfA:
21.65
1ekjF-2nxfA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 8 ASP A 151
GLY A 200
GLY A 199
GLN A 205
 None
 0.80A 1ekjG-2nxfA:
undetectable
1ekjH-2nxfA:
undetectable		 1ekjG-2nxfA:
21.65
1ekjH-2nxfA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		5 / 12 ILE A 155
GLY A  64
ALA A  75
SER A  72
GLY A  95
 None
 1.11A 1nbhB-2nxfA:
undetectable		 1nbhB-2nxfA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		5 / 12 ILE A 155
GLY A  64
ALA A  75
SER A  72
GLY A  95
 None
 1.13A 1nbiA-2nxfA:
undetectable		 1nbiA-2nxfA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		5 / 12 ILE A 155
GLY A  64
ALA A  75
SER A  72
GLY A  95
 None
 1.13A 1nbiB-2nxfA:
undetectable		 1nbiB-2nxfA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		5 / 12 VAL A  14
GLU A  98
GLY A  95
ASN A 198
GLN A 205
 None
 1.14A 1vidA-2nxfA:
undetectable		 1vidA-2nxfA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 5 PRO A 184
VAL A 195
ASN A 175
ILE A 239
 None
 1.10A 1z2bC-2nxfA:
undetectable		 1z2bC-2nxfA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.10A 1zzrA-2nxfA:
undetectable
1zzrB-2nxfA:
undetectable		 1zzrA-2nxfA:
22.70
1zzrB-2nxfA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.15A 1zzrA-2nxfA:
undetectable
1zzrB-2nxfA:
undetectable		 1zzrA-2nxfA:
22.70
1zzrB-2nxfA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.11A 1zzuA-2nxfA:
0.5
1zzuB-2nxfA:
undetectable		 1zzuA-2nxfA:
22.70
1zzuB-2nxfA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.12A 1zzuA-2nxfA:
0.5
1zzuB-2nxfA:
undetectable		 1zzuA-2nxfA:
22.70
1zzuB-2nxfA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A  99
PHE A 201
PHE A 261
GLY A  95
 None
 0.98A 2v0mC-2nxfA:
undetectable		 2v0mC-2nxfA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 4 LEU A 301
ASP A  89
VAL A  52
THR A 298
 None
None
EOH  A 502 (-4.7A)
None
 1.29A 3cyxB-2nxfA:
undetectable		 3cyxB-2nxfA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.13A 3dqrA-2nxfA:
undetectable
3dqrB-2nxfA:
undetectable		 3dqrA-2nxfA:
22.59
3dqrB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.15A 3dqrA-2nxfA:
undetectable
3dqrB-2nxfA:
undetectable		 3dqrA-2nxfA:
22.59
3dqrB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.12A 3jx2A-2nxfA:
undetectable
3jx2B-2nxfA:
undetectable		 3jx2A-2nxfA:
22.59
3jx2B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.14A 3jx2A-2nxfA:
undetectable
3jx2B-2nxfA:
undetectable		 3jx2A-2nxfA:
22.59
3jx2B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.10A 3jx3A-2nxfA:
undetectable
3jx3B-2nxfA:
0.2		 3jx3A-2nxfA:
22.59
3jx3B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.15A 3jx3A-2nxfA:
undetectable
3jx3B-2nxfA:
0.2		 3jx3A-2nxfA:
22.59
3jx3B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 6 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.14A 3jx4A-2nxfA:
undetectable
3jx4B-2nxfA:
0.4		 3jx4A-2nxfA:
22.59
3jx4B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.18A 3jx4A-2nxfA:
undetectable
3jx4B-2nxfA:
0.3		 3jx4A-2nxfA:
22.59
3jx4B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.13A 3jx5A-2nxfA:
undetectable
3jx5B-2nxfA:
0.4		 3jx5A-2nxfA:
22.59
3jx5B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.18A 3jx5A-2nxfA:
undetectable
3jx5B-2nxfA:
0.4		 3jx5A-2nxfA:
22.59
3jx5B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.19A 3jx6A-2nxfA:
0.4
3jx6B-2nxfA:
0.4		 3jx6A-2nxfA:
22.59
3jx6B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.16A 3jx6A-2nxfA:
0.4
3jx6B-2nxfA:
0.4		 3jx6A-2nxfA:
22.59
3jx6B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.16A 3nljA-2nxfA:
0.2
3nljB-2nxfA:
undetectable		 3nljA-2nxfA:
22.59
3nljB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.20A 3nljA-2nxfA:
0.1
3nljB-2nxfA:
undetectable		 3nljA-2nxfA:
22.59
3nljB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.12A 3nlpA-2nxfA:
undetectable
3nlpB-2nxfA:
0.4		 3nlpA-2nxfA:
22.59
3nlpB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.17A 3nlpA-2nxfA:
undetectable
3nlpB-2nxfA:
0.4		 3nlpA-2nxfA:
22.59
3nlpB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 8 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.13A 3nlqA-2nxfA:
undetectable
3nlqB-2nxfA:
undetectable		 3nlqA-2nxfA:
22.59
3nlqB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.13A 3nlqA-2nxfA:
undetectable
3nlqB-2nxfA:
undetectable		 3nlqA-2nxfA:
22.59
3nlqB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.12A 3nlrA-2nxfA:
undetectable
3nlrB-2nxfA:
undetectable		 3nlrA-2nxfA:
22.59
3nlrB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 8 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.15A 3nlrA-2nxfA:
undetectable
3nlrB-2nxfA:
undetectable		 3nlrA-2nxfA:
22.59
3nlrB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		5 / 10 ASP A  13
HIS A 228
GLY A 312
GLY A 264
MET A 308
 ZN  A 401 (-3.1A)
ZN  A 402 (-3.4A)
None
None
None
 1.40A 3v3oD-2nxfA:
0.6		 3v3oD-2nxfA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.08A 4cx3A-2nxfA:
0.4
4cx3B-2nxfA:
undetectable		 4cx3A-2nxfA:
22.59
4cx3B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.12A 4cx3A-2nxfA:
0.4
4cx3B-2nxfA:
undetectable		 4cx3A-2nxfA:
22.59
4cx3B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.08A 4cx4A-2nxfA:
undetectable
4cx4B-2nxfA:
undetectable		 4cx4A-2nxfA:
22.59
4cx4B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.11A 4cx4A-2nxfA:
undetectable
4cx4B-2nxfA:
undetectable		 4cx4A-2nxfA:
22.59
4cx4B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 GLY A 269
ASP A 266
GLY A 285
GLU A 288
 None
 0.85A 4koeA-2nxfA:
undetectable
4koeB-2nxfA:
undetectable
4koeD-2nxfA:
undetectable		 4koeA-2nxfA:
22.56
4koeB-2nxfA:
22.56
4koeD-2nxfA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		5 / 12 GLY A 270
GLY A 264
ASP A  13
ILE A 287
ASP A 266
 None
None
ZN  A 401 (-3.1A)
None
None
 1.26A 4rtsA-2nxfA:
undetectable		 4rtsA-2nxfA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		3 / 5 GLY A 269
GLY A 285
GLU A 288
 None
 0.41A 4z2eA-2nxfA:
undetectable
4z2eD-2nxfA:
undetectable		 4z2eA-2nxfA:
21.87
4z2eD-2nxfA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 6 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.13A 5addA-2nxfA:
undetectable
5addB-2nxfA:
undetectable		 5addA-2nxfA:
22.59
5addB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.15A 5addA-2nxfA:
undetectable
5addB-2nxfA:
undetectable		 5addA-2nxfA:
22.59
5addB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 6 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.22A 5adeA-2nxfA:
undetectable
5adeB-2nxfA:
undetectable		 5adeA-2nxfA:
22.59
5adeB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.24A 5adeA-2nxfA:
undetectable
5adeB-2nxfA:
undetectable		 5adeA-2nxfA:
22.59
5adeB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.13A 5g0pA-2nxfA:
undetectable
5g0pB-2nxfA:
undetectable		 5g0pA-2nxfA:
22.59
5g0pB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.16A 5g0pA-2nxfA:
undetectable
5g0pB-2nxfA:
undetectable		 5g0pA-2nxfA:
22.59
5g0pB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		3 / 3 LYS A 163
LEU A 171
ILE A 155
 None
 0.80A 5kc4A-2nxfA:
undetectable		 5kc4A-2nxfA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
GLY A 310
GLY A 312
HIS A 294
 None
 0.68A 5n9xA-2nxfA:
undetectable		 5n9xA-2nxfA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		5 / 12 LEU A 301
ILE A 262
LEU A 259
ALA A 297
LEU A 317
 None
 1.01A 5og9B-2nxfA:
undetectable		 5og9B-2nxfA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		3 / 3 LEU A  76
ASP A  13
ILE A  11
 None
ZN  A 401 (-3.1A)
None
 0.56A 6dh0B-2nxfA:
undetectable		 6dh0B-2nxfA:
14.24