SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nxg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2nxg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Aquifex
aeolicus) 		5 / 10 ASP A1182
ASN A1122
ILE A1097
GLU A1222
GLY A1009
 None
None
None
PEP  A1268 ( 4.4A)
None
 1.20A 1mehA-2nxgA:
11.0		 1mehA-2nxgA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 2nxg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Aquifex
aeolicus) 		5 / 11 LEU A1243
ILE A1026
LEU A1076
PHE A1074
LYS A1021
 None
 1.31A 2bxmA-2nxgA:
undetectable		 2bxmA-2nxgA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2nxg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Aquifex
aeolicus) 		4 / 7 VAL A1165
SER A1186
LEU A1170
THR A1152
 None
 1.03A 2f78B-2nxgA:
undetectable		 2f78B-2nxgA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 2nxg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Aquifex
aeolicus) 		5 / 12 ILE A1180
THR A1184
THR A1152
ILE A1097
ILE A1007
 None
 1.26A 2yzqA-2nxgA:
undetectable		 2yzqA-2nxgA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQZ_A_LQZA586_1
(SERUM ALBUMIN)		 2nxg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Aquifex
aeolicus) 		4 / 6 ARG A1154
ASP A1182
LYS A1124
LYS A1041
 PEP  A1268 (-3.7A)
None
PEP  A1268 (-2.6A)
PEP  A1268 (-3.3A)
 1.44A 3jqzA-2nxgA:
0.0		 3jqzA-2nxgA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_B_ACTB901_0
(PYRANOSE 2-OXIDASE)		 2nxg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Aquifex
aeolicus) 		4 / 6 SER A1043
GLN A1099
PHE A1220
HIS A1185
 PEP  A1268 (-3.6A)
PEP  A1268 (-4.0A)
PEP  A1268 (-4.6A)
PEP  A1268 (-4.1A)
 1.26A 3lskB-2nxgA:
undetectable		 3lskB-2nxgA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_D_ACTD901_0
(PYRANOSE 2-OXIDASE)		 2nxg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Aquifex
aeolicus) 		4 / 6 SER A1043
GLN A1099
PHE A1220
HIS A1185
 PEP  A1268 (-3.6A)
PEP  A1268 (-4.0A)
PEP  A1268 (-4.6A)
PEP  A1268 (-4.1A)
 1.27A 3lskD-2nxgA:
undetectable		 3lskD-2nxgA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2nxg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Aquifex
aeolicus) 		5 / 11 ILE A1208
ALA A1008
ALA A1237
ALA A1183
THR A1184
 None
 1.05A 3mdtB-2nxgA:
undetectable		 3mdtB-2nxgA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 2nxg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Aquifex
aeolicus) 		5 / 12 GLY A1144
ALA A1115
ILE A1098
VAL A1123
VAL A1121
 None
 0.97A 3ucbA-2nxgA:
undetectable		 3ucbA-2nxgA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 2nxg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Aquifex
aeolicus) 		5 / 12 GLY A1144
ALA A1115
ILE A1098
VAL A1123
VAL A1121
 None
 0.99A 3ucbB-2nxgA:
undetectable		 3ucbB-2nxgA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 2nxg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Aquifex
aeolicus) 		4 / 5 GLY A1155
THR A1156
GLY A1126
GLU A1153
 None
 1.15A 4v20A-2nxgA:
undetectable		 4v20A-2nxgA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 2nxg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Aquifex
aeolicus) 		3 / 3 LYS A1041
ILE A1007
ILE A1180
 PEP  A1268 (-3.3A)
None
None
 0.57A 4y0qA-2nxgA:
undetectable		 4y0qA-2nxgA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2nxg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Aquifex
aeolicus) 		4 / 6 VAL A1123
LEU A1151
CYH A1105
LEU A1129
 None
 1.24A 5hrqB-2nxgA:
undetectable
5hrqI-2nxgA:
undetectable
5hrqJ-2nxgA:
undetectable		 5hrqB-2nxgA:
8.37
5hrqI-2nxgA:
4.72
5hrqJ-2nxgA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 2nxg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Aquifex
aeolicus) 		4 / 7 SER A1043
ASP A1081
PRO A1101
SER A1232
 PEP  A1268 (-3.6A)
PEP  A1268 ( 4.5A)
PEP  A1268 (-4.0A)
None
 1.20A 5l1fC-2nxgA:
undetectable		 5l1fC-2nxgA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2nxg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Aquifex
aeolicus) 		3 / 3 LYS A1032
LEU A1029
ARG A1028
 None
 0.89A 5yw0A-2nxgA:
undetectable		 5yw0A-2nxgA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2nxg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Aquifex
aeolicus) 		4 / 5 ARG A1049
ARG A1056
GLY A1057
ASP A1045
 A5P  A1269 (-4.0A)
None
None
None
 1.38A 6dwjB-2nxgA:
undetectable
6dwjD-2nxgA:
undetectable		 6dwjB-2nxgA:
18.13
6dwjD-2nxgA:
18.13