SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nxo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 2nxo HYPOTHETICAL PROTEIN
SCO4506
(Streptomyces
coelicolor) 		5 / 10 ARG A 192
GLU A 277
ALA A  71
ALA A 189
GLY A  55
 None
 1.31A 1mjqG-2nxoA:
undetectable
1mjqH-2nxoA:
undetectable		 1mjqG-2nxoA:
16.32
1mjqH-2nxoA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 2nxo HYPOTHETICAL PROTEIN
SCO4506
(Streptomyces
coelicolor) 		3 / 3 VAL A  48
GLU A  61
GLU A  45
 None
 0.69A 2nv4A-2nxoA:
undetectable		 2nv4A-2nxoA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2nxo HYPOTHETICAL PROTEIN
SCO4506
(Streptomyces
coelicolor) 		5 / 12 LEU A 171
ILE A 149
LEU A  97
PRO A 127
VAL A 125
 None
 1.16A 2po5A-2nxoA:
undetectable		 2po5A-2nxoA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 2nxo HYPOTHETICAL PROTEIN
SCO4506
(Streptomyces
coelicolor) 		5 / 12 ILE A 149
ASP A 135
ASP A 151
GLY A 150
THR A 107
 None
 1.05A 3bwcA-2nxoA:
undetectable		 3bwcA-2nxoA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 2nxo HYPOTHETICAL PROTEIN
SCO4506
(Streptomyces
coelicolor) 		5 / 6 LEU A  20
SER A 216
LEU A 215
ARG A 213
LEU A  24
 None
 1.48A 3f33A-2nxoA:
undetectable		 3f33A-2nxoA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2nxo HYPOTHETICAL PROTEIN
SCO4506
(Streptomyces
coelicolor) 		4 / 6 ASP A 151
LEU A 154
ALA A 227
LEU A  18
 None
 1.03A 3rozA-2nxoA:
undetectable		 3rozA-2nxoA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 2nxo HYPOTHETICAL PROTEIN
SCO4506
(Streptomyces
coelicolor) 		4 / 8 GLY A  50
GLY A  55
ILE A  54
THR A  36
 None
 0.67A 3so9A-2nxoA:
undetectable		 3so9A-2nxoA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 2nxo HYPOTHETICAL PROTEIN
SCO4506
(Streptomyces
coelicolor) 		5 / 12 ILE A  54
ALA A 189
ILE A  75
PHE A 209
LEU A  24
 None
 1.16A 4cd2A-2nxoA:
undetectable		 4cd2A-2nxoA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 2nxo HYPOTHETICAL PROTEIN
SCO4506
(Streptomyces
coelicolor) 		4 / 5 PHE A  33
PHE A 209
ILE A  54
GLY A  55
 None
 0.72A 4ejjC-2nxoA:
undetectable		 4ejjC-2nxoA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 2nxo HYPOTHETICAL PROTEIN
SCO4506
(Streptomyces
coelicolor) 		5 / 9 VAL A 187
ALA A 186
GLY A 250
PHE A 249
GLY A  78
 None
 1.15A 4mm5A-2nxoA:
undetectable		 4mm5A-2nxoA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 2nxo HYPOTHETICAL PROTEIN
SCO4506
(Streptomyces
coelicolor) 		5 / 9 VAL A 187
ALA A 186
GLY A 250
PHE A 249
GLY A  78
 None
 1.18A 4mmbA-2nxoA:
undetectable		 4mmbA-2nxoA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 2nxo HYPOTHETICAL PROTEIN
SCO4506
(Streptomyces
coelicolor) 		5 / 10 VAL A 187
ALA A 186
GLY A 250
PHE A 249
GLY A  78
 None
 1.27A 4mmdA-2nxoA:
1.2		 4mmdA-2nxoA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 2nxo HYPOTHETICAL PROTEIN
SCO4506
(Streptomyces
coelicolor) 		5 / 9 VAL A 187
ALA A 186
GLY A 250
PHE A 249
GLY A  78
 None
 1.31A 4mmeA-2nxoA:
undetectable		 4mmeA-2nxoA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 2nxo HYPOTHETICAL PROTEIN
SCO4506
(Streptomyces
coelicolor) 		5 / 9 VAL A 187
ALA A 186
GLY A 250
PHE A 249
GLY A  78
 None
 1.21A 4mmeB-2nxoA:
undetectable		 4mmeB-2nxoA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 2nxo HYPOTHETICAL PROTEIN
SCO4506
(Streptomyces
coelicolor) 		5 / 9 VAL A  57
ILE A 201
VAL A 205
VAL A  70
ALA A 189
 None
 1.14A 4oqrA-2nxoA:
undetectable		 4oqrA-2nxoA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 2nxo HYPOTHETICAL PROTEIN
SCO4506
(Streptomyces
coelicolor) 		5 / 11 ASP A  98
ALA A 145
VAL A 102
TYR A 129
VAL A  92
 None
 1.11A 4xnxA-2nxoA:
undetectable		 4xnxA-2nxoA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nxo HYPOTHETICAL PROTEIN
SCO4506
(Streptomyces
coelicolor) 		3 / 3 THR A 107
HIS A 169
LEU A 171
 None
 0.80A 5axdA-2nxoA:
undetectable		 5axdA-2nxoA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nxo HYPOTHETICAL PROTEIN
SCO4506
(Streptomyces
coelicolor) 		3 / 3 THR A 107
HIS A 169
LEU A 171
 None
 0.81A 5axdC-2nxoA:
undetectable		 5axdC-2nxoA:
20.09