SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nxx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
ECDYSONE RECEPTOR
(ECR, NRH1)
(Tribolium
castaneum;
Tribolium
castaneum) 		5 / 12 PHE E 504
LEU E 508
ALA A 362
ILE E 319
ILE E 462
 None
 1.08A 1crbA-2nxxE:
undetectable		 1crbA-2nxxE:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 9 ILE A 342
LEU A 238
VAL A 232
ALA A 318
LEU A 321
 None
 1.17A 1e7bA-2nxxA:
undetectable		 1e7bA-2nxxA:
18.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 12 PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.73A 1fbyA-2nxxA:
24.9		 1fbyA-2nxxA:
63.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 12 PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.74A 1fbyB-2nxxA:
24.4		 1fbyB-2nxxA:
63.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 12 PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.74A 1fm6A-2nxxA:
25.2		 1fm6A-2nxxA:
63.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 12 PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.74A 1fm6U-2nxxA:
25.1		 1fm6U-2nxxA:
63.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		6 / 12 LEU A 255
PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.91A 1fm9A-2nxxA:
25.3		 1fm9A-2nxxA:
63.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 10 LEU A 255
PHE A 259
ARG A 262
LEU A 272
ALA A 273
 None
 0.61A 1g5yC-2nxxA:
24.9		 1g5yC-2nxxA:
63.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		4 / 5 THR A 350
PHE A 361
GLU A 348
GLY A 344
 None
 1.33A 1icrA-2nxxA:
undetectable
1icrB-2nxxA:
undetectable		 1icrA-2nxxA:
19.49
1icrB-2nxxA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		4 / 5 GLU A 348
GLY A 344
THR A 350
PHE A 361
 None
 1.33A 1icrA-2nxxA:
undetectable
1icrB-2nxxA:
undetectable		 1icrA-2nxxA:
19.49
1icrB-2nxxA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		4 / 5 THR A 350
PHE A 361
GLU A 348
GLY A 344
 None
 1.31A 1icvC-2nxxA:
undetectable
1icvD-2nxxA:
undetectable		 1icvC-2nxxA:
19.49
1icvD-2nxxA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		4 / 5 GLU A 348
GLY A 344
THR A 350
PHE A 361
 None
 1.27A 1icvC-2nxxA:
undetectable
1icvD-2nxxA:
undetectable		 1icvC-2nxxA:
19.49
1icvD-2nxxA:
19.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 12 LEU A 255
PHE A 259
ARG A 262
ALA A 273
CYH A 378
 None
 0.91A 1k74A-2nxxA:
25.3		 1k74A-2nxxA:
63.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 12 PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.66A 1k74A-2nxxA:
25.3		 1k74A-2nxxA:
63.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 2nxx ECDYSONE RECEPTOR
(ECR, NRH1)
ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		4 / 6 PRO E 469
PHE A 259
ILE A 374
SER A 260
 None
 1.22A 1sbrA-2nxxE:
undetectable
1sbrB-2nxxE:
undetectable		 1sbrA-2nxxE:
20.31
1sbrB-2nxxE:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 2nxx ECDYSONE RECEPTOR
(ECR, NRH1)
ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		4 / 6 GLU A 298
SER A 373
ARG E 515
ARG E 468
 None
 1.29A 1tufA-2nxxA:
undetectable
1tufB-2nxxA:
undetectable		 1tufA-2nxxA:
19.48
1tufB-2nxxA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 12 LEU A 225
LEU A 222
ILE A 320
ILE A 393
LEU A 397
 None
 0.91A 1tw4A-2nxxA:
undetectable		 1tw4A-2nxxA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nxx ECDYSONE RECEPTOR
(ECR, NRH1)
ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		3 / 3 GLU A 298
GLU E 478
LEU E 390
 None
 0.67A 1v8bA-2nxxA:
undetectable		 1v8bA-2nxxA:
18.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 12 PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.77A 1xdkA-2nxxA:
24.6		 1xdkA-2nxxA:
62.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 12 PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.77A 1xdkE-2nxxA:
24.6		 1xdkE-2nxxA:
62.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 12 PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.69A 1xiuA-2nxxA:
26.2		 1xiuA-2nxxA:
67.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 12 LEU A 255
PHE A 259
ARG A 262
ALA A 273
CYH A 378
 None
 0.92A 1xiuB-2nxxA:
26.8		 1xiuB-2nxxA:
67.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		6 / 12 LEU A 255
PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.93A 1xlsA-2nxxA:
25.4		 1xlsA-2nxxA:
64.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		6 / 12 LEU A 255
PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.94A 1xlsB-2nxxA:
25.5		 1xlsB-2nxxA:
64.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		6 / 12 LEU A 255
PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.93A 1xlsC-2nxxA:
25.5		 1xlsC-2nxxA:
64.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		6 / 12 LEU A 255
PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.93A 1xlsD-2nxxA:
25.5		 1xlsD-2nxxA:
64.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 2nxx ECDYSONE RECEPTOR
(ECR, NRH1)
(Tribolium
castaneum) 		4 / 4 LEU E 485
SER E 466
LEU E 459
LEU E 508
 None
 1.12A 1yajA-2nxxE:
undetectable		 1yajA-2nxxE:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2nxx ECDYSONE RECEPTOR
(ECR, NRH1)
(Tribolium
castaneum) 		5 / 10 LEU E 391
ALA E 373
LEU E 376
ASP E 386
LEU E 382
 None
 1.10A 1yi4A-2nxxE:
undetectable		 1yi4A-2nxxE:
23.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		6 / 12 LEU A 255
PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.91A 2aclA-2nxxA:
24.5
2aclE-2nxxA:
24.6		 2aclA-2nxxA:
63.37
2aclE-2nxxA:
63.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		7 / 12 ASN A 252
ILE A 256
PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 1.15A 2aclG-2nxxA:
23.8		 2aclG-2nxxA:
63.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		6 / 12 ASN A 252
LEU A 255
ILE A 256
ARG A 262
ALA A 273
CYH A 378
 None
 1.27A 2aclG-2nxxA:
23.8		 2aclG-2nxxA:
63.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		3 / 3 ASN A 301
TYR A 292
SER A 263
 None
 0.93A 2gvcB-2nxxA:
undetectable		 2gvcB-2nxxA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		3 / 3 ASN A 301
TYR A 292
SER A 263
 None
 0.94A 2gvcE-2nxxA:
undetectable		 2gvcE-2nxxA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 2nxx ECDYSONE RECEPTOR
(ECR, NRH1)
(Tribolium
castaneum) 		3 / 3 PHE E 442
SER E 509
LEU E 507
 None
 0.76A 2w1bA-2nxxE:
undetectable		 2w1bA-2nxxE:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_1
(HYPOTHETICAL PROTEIN)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		4 / 4 GLY A 314
GLU A 190
ASP A 309
TYR A 349
 None
 1.35A 2yvlC-2nxxA:
undetectable		 2yvlC-2nxxA:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		6 / 12 ASN A 252
ILE A 256
PHE A 259
ARG A 262
LEU A 272
CYH A 378
 None
 1.07A 3dzuA-2nxxA:
24.3		 3dzuA-2nxxA:
33.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		6 / 12 ASN A 252
PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 1.23A 3dzyA-2nxxA:
23.5		 3dzyA-2nxxA:
33.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 10 PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.74A 3falC-2nxxA:
24.6		 3falC-2nxxA:
63.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 11 PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.71A 3fc6A-2nxxA:
24.8		 3fc6A-2nxxA:
63.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 12 LEU A 255
PHE A 259
ARG A 262
ALA A 273
CYH A 378
 None
 0.95A 3fc6C-2nxxA:
25.4		 3fc6C-2nxxA:
63.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 12 PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.71A 3fc6C-2nxxA:
25.4		 3fc6C-2nxxA:
63.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		3 / 3 PRO A 239
LEU A 240
GLN A 243
 None
 0.70A 3hznG-2nxxA:
undetectable
3hznH-2nxxA:
undetectable		 3hznG-2nxxA:
20.63
3hznH-2nxxA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 12 GLY A 250
VAL A 226
ARG A 317
LEU A 401
ILE A 329
 None
 1.32A 3mnoA-2nxxA:
17.6		 3mnoA-2nxxA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 12 GLY A 250
VAL A 226
ARG A 317
LEU A 401
ILE A 329
 None
 1.31A 3mnpA-2nxxA:
17.1		 3mnpA-2nxxA:
24.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 12 PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.68A 3oapA-2nxxA:
25.3		 3oapA-2nxxA:
63.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 2nxx ECDYSONE RECEPTOR
(ECR, NRH1)
(Tribolium
castaneum) 		3 / 3 GLU E 473
LEU E 383
LEU E 391
 None
 0.77A 3ohtB-2nxxE:
undetectable		 3ohtB-2nxxE:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		4 / 6 LEU A 255
LYS A 386
PHE A 383
GLY A 287
 None
 1.02A 3sj1X-2nxxA:
undetectable		 3sj1X-2nxxA:
17.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		6 / 12 ILE A 256
PHE A 259
ARG A 262
LEU A 272
ALA A 273
VAL A 295
 None
 0.57A 4k6iA-2nxxA:
25.0		 4k6iA-2nxxA:
63.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		6 / 12 LEU A 255
ILE A 256
PHE A 259
ARG A 262
ALA A 273
VAL A 295
 None
 0.54A 4k6iA-2nxxA:
25.0		 4k6iA-2nxxA:
63.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2nxx ECDYSONE RECEPTOR
(ECR, NRH1)
(Tribolium
castaneum) 		4 / 8 LEU E 514
LEU E 511
LEU E 508
VAL E 451
 None
 0.83A 4klaA-2nxxE:
undetectable		 4klaA-2nxxE:
20.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 12 PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.69A 4nqaH-2nxxA:
24.8		 4nqaH-2nxxA:
42.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 12 LEU A 316
ARG A 317
PHE A 383
ALA A 258
SER A 260
 None
 1.04A 4o1zB-2nxxA:
undetectable		 4o1zB-2nxxA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 2nxx ECDYSONE RECEPTOR
(ECR, NRH1)
(Tribolium
castaneum) 		3 / 3 LEU E 440
MET E 400
TYR E 447
 None
P1A  E   5 ( 4.4A)
None
 0.60A 4p6xG-2nxxE:
22.5		 4p6xG-2nxxE:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
ECDYSONE RECEPTOR
(ECR, NRH1)
(Tribolium
castaneum;
Tribolium
castaneum) 		3 / 3 SER E 509
TYR A 343
ASP A 325
 None
 0.82A 4rp8C-2nxxE:
undetectable		 4rp8C-2nxxE:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1007_1
(SERUM ALBUMIN)		 2nxx ECDYSONE RECEPTOR
(ECR, NRH1)
(Tribolium
castaneum) 		5 / 9 ARG E 489
LEU E 485
LEU E 511
SER E 509
ALA E 505
 None
 1.30A 4z69A-2nxxE:
0.0		 4z69A-2nxxE:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nxx ECDYSONE RECEPTOR
(ECR, NRH1)
(Tribolium
castaneum) 		3 / 3 THR E 365
HIS E 441
LEU E 517
 P1A  E   5 ( 3.7A)
None
None
 0.85A 5axdC-2nxxE:
undetectable		 5axdC-2nxxE:
20.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		6 / 11 LEU A 255
PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.90A 5ji0A-2nxxA:
24.8		 5ji0A-2nxxA:
63.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 12 PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.73A 5uanA-2nxxA:
24.4		 5uanA-2nxxA:
42.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		4 / 8 HIS A 381
TRP A 251
ASP A 242
LEU A 240
 None
 1.18A 5x19A-2nxxA:
undetectable
5x19C-2nxxA:
undetectable
5x19P-2nxxA:
undetectable		 5x19A-2nxxA:
16.70
5x19C-2nxxA:
22.14
5x19P-2nxxA:
22.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		6 / 12 LEU A 255
PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.96A 5z12B-2nxxA:
25.4		 5z12B-2nxxA:
52.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 12 PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.75A 5z12C-2nxxA:
24.3		 5z12C-2nxxA:
52.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		6 / 12 PHE A 259
ARG A 262
LEU A 272
ALA A 273
ILE A 291
CYH A 378
 None
 0.94A 6a5yD-2nxxA:
25.6		 6a5yD-2nxxA:
52.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 12 ILE A 256
PHE A 259
ARG A 262
LEU A 272
ALA A 273
 None
 0.62A 6a5zD-2nxxA:
25.4		 6a5zD-2nxxA:
52.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 12 ILE A 256
PHE A 259
ARG A 262
LEU A 272
CYH A 378
 None
 0.73A 6a5zD-2nxxA:
25.4		 6a5zD-2nxxA:
52.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 12 PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.77A 6a5zL-2nxxA:
25.2		 6a5zL-2nxxA:
52.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nxx ULTRASPIRACLE (USP,
NR2B4)
(Tribolium
castaneum) 		5 / 12 LEU A 255
PHE A 259
ARG A 262
ALA A 273
CYH A 378
 None
 0.97A 6a60D-2nxxA:
25.1		 6a60D-2nxxA:
52.33