SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nyf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		5 / 10 ASP A 373
GLY A 369
GLN A 366
VAL A 370
GLY A 458
 None
 1.41A 1fohA-2nyfA:
undetectable		 1fohA-2nyfA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		5 / 10 ASP A 373
GLY A 369
GLN A 366
VAL A 370
GLY A 458
 None
 1.39A 1fohB-2nyfA:
undetectable		 1fohB-2nyfA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		4 / 8 ALA A 220
ILE A 177
ILE A 144
ILE A 139
 None
 0.63A 1hshD-2nyfA:
undetectable		 1hshD-2nyfA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		5 / 12 THR A 334
GLY A 329
GLY A 380
ALA A 239
VAL A 236
 None
 1.12A 1jg4A-2nyfA:
undetectable		 1jg4A-2nyfA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		5 / 10 ASP A 373
GLY A 369
GLN A 366
VAL A 370
GLY A 458
 None
 1.37A 1pn0A-2nyfA:
undetectable		 1pn0A-2nyfA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_B_IPHB6022_0
(PHENOL
2-MONOOXYGENASE)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		5 / 10 ASP A 373
GLY A 369
GLN A 366
VAL A 370
GLY A 458
 None
 1.39A 1pn0B-2nyfA:
undetectable		 1pn0B-2nyfA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		5 / 10 ASP A 373
GLY A 369
GLN A 366
VAL A 370
GLY A 458
 None
 1.41A 1pn0C-2nyfA:
undetectable		 1pn0C-2nyfA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		5 / 10 ASP A 373
GLY A 369
GLN A 366
VAL A 370
GLY A 458
 None
 1.40A 1pn0D-2nyfA:
0.8		 1pn0D-2nyfA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		4 / 5 ALA A 233
TYR A 237
ALA A 123
GLN A 473
 None
 0.83A 1xl6A-2nyfA:
2.5
1xl6B-2nyfA:
3.8		 1xl6A-2nyfA:
21.95
1xl6B-2nyfA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		3 / 3 ASN A 532
TRP A 531
GLN A 536
 None
 1.07A 1xoqA-2nyfA:
undetectable		 1xoqA-2nyfA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		5 / 12 GLY A 552
GLY A 553
VAL A 518
LEU A 554
LEU A 242
 None
 1.05A 1ya4B-2nyfA:
undetectable		 1ya4B-2nyfA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		5 / 12 GLY A 552
GLY A 553
VAL A 518
LEU A 554
LEU A 242
 None
 1.06A 1ya4C-2nyfA:
undetectable		 1ya4C-2nyfA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		3 / 3 ALA A 251
THR A 508
PHE A 264
 None
 0.71A 2c6nB-2nyfA:
0.0		 2c6nB-2nyfA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		4 / 6 ARG A 490
GLN A 485
PHE A 482
LEU A 257
 None
 1.12A 2einP-2nyfA:
3.3
2einW-2nyfA:
undetectable		 2einP-2nyfA:
17.96
2einW-2nyfA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		5 / 10 ALA A 202
THR A 201
ALA A 199
VAL A 155
GLY A 207
 None
 1.05A 2f16K-2nyfA:
undetectable
2f16L-2nyfA:
undetectable		 2f16K-2nyfA:
16.02
2f16L-2nyfA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		5 / 10 ALA A 202
THR A 201
ALA A 199
VAL A 155
GLY A 207
 None
 1.05A 2f16Y-2nyfA:
undetectable
2f16Z-2nyfA:
undetectable		 2f16Y-2nyfA:
16.02
2f16Z-2nyfA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		5 / 12 HIS A 561
LEU A 566
VAL A 330
LEU A 511
LEU A 287
 None
 1.32A 2prgB-2nyfA:
0.0		 2prgB-2nyfA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		4 / 7 ILE A 542
GLN A 473
LEU A 242
LEU A 480
 None
 1.05A 2qqcB-2nyfA:
undetectable
2qqcC-2nyfA:
undetectable		 2qqcB-2nyfA:
12.63
2qqcC-2nyfA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		4 / 7 LEU A 242
LEU A 480
ILE A 542
GLN A 473
 None
 1.04A 2qqcA-2nyfA:
undetectable
2qqcF-2nyfA:
undetectable		 2qqcA-2nyfA:
6.78
2qqcF-2nyfA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		4 / 7 LEU A 242
LEU A 480
ILE A 542
GLN A 473
 None
 1.07A 2qqcI-2nyfA:
undetectable
2qqcL-2nyfA:
undetectable		 2qqcI-2nyfA:
6.78
2qqcL-2nyfA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		4 / 7 ASN A 152
LEU A 151
THR A  46
VAL A  41
 None
 1.17A 2uz2A-2nyfA:
undetectable		 2uz2A-2nyfA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		5 / 9 PHE A 188
SER A 226
ALA A 129
GLY A 179
LEU A 181
 None
 1.10A 2v0mB-2nyfA:
undetectable		 2v0mB-2nyfA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		4 / 7 LEU A 108
LEU A 104
PHE A 107
GLU A 448
 None
 0.86A 2vq5B-2nyfA:
undetectable		 2vq5B-2nyfA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		4 / 7 THR A 178
ILE A 182
GLY A 179
PHE A 188
 None
 0.85A 2y7wC-2nyfA:
undetectable		 2y7wC-2nyfA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		4 / 4 ARG A 490
GLN A 485
PHE A 482
LEU A 257
 None
 1.07A 3abkC-2nyfA:
3.4		 3abkC-2nyfA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		4 / 5 ARG A 490
GLN A 485
PHE A 482
LEU A 257
 None
 1.15A 3ablC-2nyfA:
2.3
3ablJ-2nyfA:
undetectable		 3ablC-2nyfA:
17.96
3ablJ-2nyfA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		4 / 6 ARG A 490
GLN A 485
PHE A 482
LEU A 257
 None
 1.13A 3ablP-2nyfA:
2.2
3ablW-2nyfA:
undetectable		 3ablP-2nyfA:
17.96
3ablW-2nyfA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		5 / 12 ALA A  70
ALA A  97
GLY A 218
GLU A 217
VAL A 352
 None
 1.06A 3c6gB-2nyfA:
undetectable		 3c6gB-2nyfA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		4 / 7 ARG A 146
LEU A 143
GLU A 217
ILE A 182
 None
 0.90A 3s56B-2nyfA:
undetectable		 3s56B-2nyfA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		5 / 9 LEU A 245
LEU A 480
ILE A 428
ILE A 471
GLN A 473
 None
 1.23A 3tmzA-2nyfA:
1.9		 3tmzA-2nyfA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		4 / 8 THR A 513
TYR A 529
ARG A 501
LEU A 504
 None
 0.91A 3wipG-2nyfA:
undetectable
3wipH-2nyfA:
undetectable		 3wipG-2nyfA:
16.87
3wipH-2nyfA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		4 / 8 ARG A 501
LEU A 504
THR A 513
TYR A 529
 None
 0.92A 3wipF-2nyfA:
undetectable
3wipJ-2nyfA:
undetectable		 3wipF-2nyfA:
16.87
3wipJ-2nyfA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		3 / 3 ASN A 400
LEU A 406
PHE A 398
 None
 0.74A 4dajB-2nyfA:
2.4		 4dajB-2nyfA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		3 / 3 ARG A 128
TYR A 160
ASN A 463
 None
 0.75A 4ffwB-2nyfA:
undetectable		 4ffwB-2nyfA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		5 / 12 HIS A 561
LEU A 566
VAL A 330
LEU A 511
LEU A 287
 None
 1.31A 4o8fB-2nyfA:
undetectable		 4o8fB-2nyfA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		5 / 12 LEU A 316
GLN A 389
MET A 247
THR A 280
VAL A 327
 None
 1.40A 4okxA-2nyfA:
undetectable		 4okxA-2nyfA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		5 / 10 ALA A 202
THR A 201
ALA A 199
VAL A 155
GLY A 207
 None
 0.92A 4qvyK-2nyfA:
undetectable
4qvyL-2nyfA:
undetectable		 4qvyK-2nyfA:
16.34
4qvyL-2nyfA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		5 / 10 ALA A 202
THR A 201
ALA A 199
VAL A 155
GLY A 207
 None
 0.91A 4qvyY-2nyfA:
undetectable
4qvyZ-2nyfA:
undetectable		 4qvyY-2nyfA:
16.34
4qvyZ-2nyfA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		5 / 11 TYR A 475
VAL A 249
ILE A 323
ILE A 326
PHE A 472
 None
 1.35A 5hw8B-2nyfA:
undetectable		 5hw8B-2nyfA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		5 / 11 TYR A 475
VAL A 249
ILE A 323
ILE A 326
PHE A 472
 None
 1.22A 5hw8G-2nyfA:
undetectable		 5hw8G-2nyfA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		4 / 8 THR A 178
SER A 226
ALA A 220
SER A 137
 None
 1.12A 5l5fY-2nyfA:
undetectable
5l5fZ-2nyfA:
undetectable		 5l5fY-2nyfA:
16.02
5l5fZ-2nyfA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		3 / 3 TYR A 176
ALA A 112
TYR A 160
 None
 0.84A 5uunB-2nyfA:
1.4		 5uunB-2nyfA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		4 / 5 HIS A 132
MET A 222
ASN A 362
LEU A 174
 None
 1.38A 5xdhB-2nyfA:
0.0		 5xdhB-2nyfA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		5 / 12 HIS A 561
LEU A 566
ILE A 326
LEU A 511
LEU A 287
 None
 1.44A 5ycpA-2nyfA:
undetectable		 5ycpA-2nyfA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		4 / 6 ARG A 490
GLN A 485
PHE A 482
LEU A 257
 None
 1.09A 5z86C-2nyfA:
2.3
5z86J-2nyfA:
undetectable		 5z86C-2nyfA:
17.96
5z86J-2nyfA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		4 / 6 ARG A 490
GLN A 485
PHE A 482
LEU A 257
 None
 1.11A 5z86P-2nyfA:
2.3
5z86W-2nyfA:
undetectable		 5z86P-2nyfA:
17.96
5z86W-2nyfA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_B_TRPB501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		5 / 10 ARG A  43
ALA A 244
TYR A 237
VAL A 556
GLY A 553
 None
 1.48A 5zbdB-2nyfA:
undetectable		 5zbdB-2nyfA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		4 / 6 ARG A 490
GLN A 485
PHE A 482
LEU A 257
 None
 1.11A 5zcpC-2nyfA:
2.2
5zcpJ-2nyfA:
1.2		 5zcpC-2nyfA:
17.96
5zcpJ-2nyfA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		4 / 6 ARG A 490
GLN A 485
PHE A 482
LEU A 257
 None
 1.12A 5zcpP-2nyfA:
2.3
5zcpW-2nyfA:
undetectable		 5zcpP-2nyfA:
17.96
5zcpW-2nyfA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		5 / 12 GLY A 553
ASP A 548
ILE A 549
VAL A 518
ALA A 558
 None
 1.10A 6bq4B-2nyfA:
undetectable		 6bq4B-2nyfA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		4 / 4 LEU A 242
ASP A 238
GLN A 473
VAL A 487
 None
 1.49A 6bzoF-2nyfA:
1.2		 6bzoF-2nyfA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		5 / 10 SER A 331
LEU A 382
LEU A 375
ILE A 323
GLY A 324
 None
 0.95A 6dm0B-2nyfA:
2.8
6dm0C-2nyfA:
2.5		 6dm0B-2nyfA:
9.72
6dm0C-2nyfA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		4 / 7 GLY A  45
HIS A  44
VAL A  39
SER A  24
 None
 1.05A 6hu9S-2nyfA:
undetectable
6hu9q-2nyfA:
0.3		 6hu9S-2nyfA:
11.76
6hu9q-2nyfA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE
(Nostoc
punctiforme) 		4 / 6 ARG A 490
GLN A 485
PHE A 482
LEU A 257
 None
 1.14A 6nmpC-2nyfA:
3.5
6nmpJ-2nyfA:
undetectable		 6nmpC-2nyfA:
17.96
6nmpJ-2nyfA:
7.82