SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nyg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 2nyg YOKD PROTEIN
(Bacillus
subtilis) 		4 / 7 THR A 108
ASN A 102
TYR A 101
LEU A  75
 None
 0.99A 1qzrB-2nygA:
undetectable		 1qzrB-2nygA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 2nyg YOKD PROTEIN
(Bacillus
subtilis) 		5 / 8 GLY A 243
SER A 244
ALA A 245
LEU A  39
ILE A   5
 None
None
None
COA  A 301 (-4.3A)
COA  A 301 (-4.3A)
 1.03A 1yajC-2nygA:
undetectable		 1yajC-2nygA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2nyg YOKD PROTEIN
(Bacillus
subtilis) 		3 / 3 LEU A 161
PRO A 160
LEU A 164
 None
 0.55A 2po5B-2nygA:
undetectable		 2po5B-2nygA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2nyg YOKD PROTEIN
(Bacillus
subtilis) 		3 / 3 LEU A 161
PRO A 160
LEU A 164
 None
 0.56A 2po7B-2nygA:
undetectable		 2po7B-2nygA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)		 2nyg YOKD PROTEIN
(Bacillus
subtilis) 		6 / 10 GLY A 175
ALA A 176
GLY A 113
ILE A 115
PRO A  69
LEU A  34
 None
COA  A 301 (-3.0A)
COA  A 301 (-3.2A)
None
None
None
 1.41A 3ttpB-2nygA:
undetectable		 3ttpB-2nygA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2nyg YOKD PROTEIN
(Bacillus
subtilis) 		4 / 8 MET A 237
GLU A 232
ALA A 255
VAL A 171
 None
 0.95A 4iizB-2nygA:
undetectable		 4iizB-2nygA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2nyg YOKD PROTEIN
(Bacillus
subtilis) 		5 / 12 VAL A 171
SER A  37
LEU A  56
VAL A  33
THR A 182
 None
 1.29A 4kyaB-2nygA:
undetectable		 4kyaB-2nygA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2nyg YOKD PROTEIN
(Bacillus
subtilis) 		5 / 12 VAL A 171
SER A  37
LEU A  56
VAL A  33
THR A 182
 None
 1.29A 4kyaH-2nygA:
undetectable		 4kyaH-2nygA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nyg YOKD PROTEIN
(Bacillus
subtilis) 		4 / 7 VAL A 227
PHE A 258
HIS A 235
GLU A 232
 None
 1.43A 5ad9A-2nygA:
undetectable
5ad9B-2nygA:
undetectable		 5ad9A-2nygA:
20.28
5ad9B-2nygA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 2nyg YOKD PROTEIN
(Bacillus
subtilis) 		4 / 5 GLN A  54
ILE A  53
ILE A  66
TYR A 122
 None
 0.83A 5dnuA-2nygA:
undetectable		 5dnuA-2nygA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 2nyg YOKD PROTEIN
(Bacillus
subtilis) 		4 / 5 GLN A  54
ILE A  53
ILE A  66
TYR A 122
 None
 0.82A 5dnvA-2nygA:
undetectable		 5dnvA-2nygA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2nyg YOKD PROTEIN
(Bacillus
subtilis) 		3 / 3 LYS A  29
LEU A  22
ILE A  66
 None
 0.63A 5kc0A-2nygA:
undetectable		 5kc0A-2nygA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2nyg YOKD PROTEIN
(Bacillus
subtilis) 		3 / 3 LYS A  29
LEU A  22
ILE A  66
 None
 0.61A 5kc4A-2nygA:
undetectable		 5kc4A-2nygA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2nyg YOKD PROTEIN
(Bacillus
subtilis) 		5 / 12 LEU A 252
LEU A 161
LEU A  56
PHE A 135
LEU A  27
 None
 1.14A 5ljeA-2nygA:
undetectable		 5ljeA-2nygA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 2nyg YOKD PROTEIN
(Bacillus
subtilis) 		5 / 12 PHE A 250
SER A 181
ALA A 255
ALA A 259
GLN A 225
 None
 0.97A 5w4zB-2nygA:
undetectable		 5w4zB-2nygA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 2nyg YOKD PROTEIN
(Bacillus
subtilis) 		5 / 12 VAL A  52
VAL A 242
LEU A  25
PHE A 250
VAL A  60
 None
 1.11A 6ajiA-2nygA:
undetectable		 6ajiA-2nygA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 2nyg YOKD PROTEIN
(Bacillus
subtilis) 		3 / 3 HIS A 130
ASN A 132
LEU A  75
 None
 0.62A 6f7lB-2nygA:
undetectable		 6f7lB-2nygA:
19.69