SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nyk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IHI_A_IU5A326_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 2nyk M157
(Murid
betaherpesvirus
1) 		5 / 10 VAL A 123
TYR A 125
HIS A 116
VAL A 121
LEU A  86
 None
 1.46A 1ihiA-2nykA:
undetectable		 1ihiA-2nykA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 2nyk M157
(Murid
betaherpesvirus
1) 		4 / 7 PHE A  75
THR A 150
VAL A 114
ILE A 153
 None
 0.91A 1p7rA-2nykA:
undetectable		 1p7rA-2nykA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2nyk M157
(Murid
betaherpesvirus
1) 		4 / 7 THR A 219
GLU A 221
THR A 230
VAL A 195
 None
 0.56A 3em0B-2nykA:
undetectable		 3em0B-2nykA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 2nyk M157
(Murid
betaherpesvirus
1) 		3 / 3 GLU A  26
VAL A  99
CYH A  98
 None
 0.96A 3fbxA-2nykA:
undetectable		 3fbxA-2nykA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2nyk M157
(Murid
betaherpesvirus
1) 		4 / 5 LEU A  83
TYR A 151
MET A 152
ARG A 122
 None
 1.47A 4bkjB-2nykA:
undetectable		 4bkjB-2nykA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I90_A_ACTA500_0
(1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE)		 2nyk M157
(Murid
betaherpesvirus
1) 		3 / 3 LYS A  80
ARG A  37
TRP A  50
 None
 1.22A 4i90A-2nykA:
undetectable		 4i90A-2nykA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2nyk M157
(Murid
betaherpesvirus
1) 		5 / 8 VAL A 123
TYR A 125
HIS A 116
VAL A 121
LEU A  86
 None
 1.48A 4jq1B-2nykA:
undetectable		 4jq1B-2nykA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQA_A_ID8A401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2nyk M157
(Murid
betaherpesvirus
1) 		5 / 9 VAL A 123
TYR A 125
HIS A 116
VAL A 121
LEU A  86
 None
 1.47A 4jqaA-2nykA:
undetectable		 4jqaA-2nykA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQA_B_ID8B401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2nyk M157
(Murid
betaherpesvirus
1) 		5 / 9 VAL A 123
TYR A 125
HIS A 116
VAL A 121
LEU A  86
 None
 1.44A 4jqaB-2nykA:
undetectable		 4jqaB-2nykA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2nyk M157
(Murid
betaherpesvirus
1) 		5 / 10 VAL A 123
TYR A 125
HIS A 116
VAL A 121
LEU A  86
 None
 1.46A 4jtqA-2nykA:
undetectable		 4jtqA-2nykA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_B_FLPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2nyk M157
(Murid
betaherpesvirus
1) 		5 / 9 VAL A 123
TYR A 125
HIS A 116
VAL A 121
LEU A  86
 None
 1.41A 4jtqB-2nykA:
undetectable		 4jtqB-2nykA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 2nyk M157
(Murid
betaherpesvirus
1) 		3 / 3 VAL A 195
THR A 193
ARG A 260
 None
NAG  A 311 ( 4.9A)
None
 0.78A 5b2sB-2nykA:
undetectable		 5b2sB-2nykA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 2nyk M157
(Murid
betaherpesvirus
1) 		3 / 3 VAL A 195
THR A 193
ARG A 260
 None
NAG  A 311 ( 4.9A)
None
 0.73A 5b2tB-2nykA:
undetectable		 5b2tB-2nykA:
11.36