SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nym'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 7 GLY C  90
ALA C 262
HIS C  63
THR C  96
 None
 0.92A 1c9sT-2nymC:
undetectable
1c9sU-2nymC:
undetectable		 1c9sT-2nymC:
13.83
1c9sU-2nymC:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 8 ASP C 202
GLY C 168
GLY C 169
GLN C 242
 None
 0.84A 1ekjA-2nymC:
undetectable
1ekjB-2nymC:
undetectable		 1ekjA-2nymC:
20.79
1ekjB-2nymC:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 7 ASP C 202
GLY C 168
GLY C 169
GLN C 242
 None
 0.89A 1ekjE-2nymC:
undetectable
1ekjF-2nymC:
undetectable		 1ekjE-2nymC:
20.79
1ekjF-2nymC:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 8 ASP C 202
GLY C 168
GLY C 169
GLN C 242
 None
 0.84A 1ekjG-2nymC:
undetectable
1ekjH-2nymC:
undetectable		 1ekjG-2nymC:
20.79
1ekjH-2nymC:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		5 / 12 ASP C  88
THR C 258
GLY C  56
VAL C  54
ALA C 262
 None
 1.09A 1nw5A-2nymC:
undetectable		 1nw5A-2nymC:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		3 / 3 ASP C  85
HIS C 118
HIS C  59
 MN  C 501 ( 2.3A)
None
MN  C 502 (-3.5A)
 0.54A 1oe1A-2nymC:
undetectable		 1oe1A-2nymC:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		3 / 3 ASP C  85
HIS C 118
HIS C  59
 MN  C 501 ( 2.3A)
None
MN  C 502 (-3.5A)
 0.52A 1oe3A-2nymC:
undetectable		 1oe3A-2nymC:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		5 / 12 THR C  53
PHE C 286
PHE C 289
VAL C 244
ALA C 240
 None
 1.30A 1q23A-2nymC:
undetectable
1q23B-2nymC:
undetectable		 1q23A-2nymC:
20.78
1q23B-2nymC:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		5 / 12 THR C  53
PHE C 286
PHE C 289
VAL C 244
ALA C 240
 None
 1.43A 1q23D-2nymC:
undetectable
1q23E-2nymC:
undetectable		 1q23D-2nymC:
20.78
1q23E-2nymC:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		5 / 12 LEU C 170
ILE C 174
LEU C 158
VAL C  45
LEU C 177
 None
 1.22A 2bxfB-2nymC:
undetectable		 2bxfB-2nymC:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 6 PRO C 203
LEU C 170
ARG C 214
GLY C 217
 None
 1.04A 2hs2B-2nymC:
undetectable		 2hs2B-2nymC:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 5 VAL C 257
THR C 258
VAL C 244
GLY C 247
 None
 1.15A 2p2fA-2nymC:
undetectable		 2p2fA-2nymC:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 4 VAL C 257
THR C 258
VAL C 244
GLY C 247
 None
 1.15A 2p2fB-2nymC:
undetectable		 2p2fB-2nymC:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		3 / 3 ASP C  85
HIS C 118
HIS C  59
 MN  C 501 ( 2.3A)
None
MN  C 502 (-3.5A)
 0.56A 2xxgA-2nymC:
undetectable		 2xxgA-2nymC:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		3 / 3 ASP C  85
HIS C 118
HIS C  59
 MN  C 501 ( 2.3A)
None
MN  C 502 (-3.5A)
 0.57A 2xxgC-2nymC:
undetectable		 2xxgC-2nymC:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		5 / 12 LEU C 236
ASN C 232
ASP C 175
TYR C 284
ASN C 255
 None
 1.21A 3eeoA-2nymC:
undetectable		 3eeoA-2nymC:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 8 GLY C 116
HIS C 241
ILE C 123
VAL C 189
 None
MN  C 501 (-3.1A)
None
None
 0.76A 3fi0I-2nymC:
undetectable		 3fi0I-2nymC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		5 / 12 TYR C 265
GLY C 247
ASP C  57
ALA C 240
VAL C 244
 None
None
MN  C 502 ( 3.2A)
None
None
 1.08A 3nvkF-2nymC:
undetectable
3nvkJ-2nymC:
undetectable		 3nvkF-2nymC:
22.45
3nvkJ-2nymC:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 5 GLY C  56
ASP C  57
ARG C 239
GLN C 288
 None
MN  C 502 ( 3.2A)
None
None
 1.39A 3qx3A-2nymC:
undetectable		 3qx3A-2nymC:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 5 GLY C  56
ASP C  57
ARG C 239
GLN C 288
 None
MN  C 502 ( 3.2A)
None
None
 1.45A 3qx3B-2nymC:
undetectable		 3qx3B-2nymC:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RZE_A_D7VA1201_1
(HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		5 / 12 ASP C 131
TYR C 130
THR C 124
ILE C 123
TRP C 143
 None
 0.93A 3rzeA-2nymC:
undetectable		 3rzeA-2nymC:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 5 PHE C 228
LEU C 198
GLY C 168
VAL C 256
 None
 1.06A 3wrkD-2nymC:
undetectable		 3wrkD-2nymC:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		3 / 3 TYR C 267
HIS C  63
ARG C 294
 None
 1.14A 4htfA-2nymC:
undetectable		 4htfA-2nymC:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		5 / 12 TYR C 218
GLY C 169
ASP C  85
HIS C 241
GLY C 116
 None
None
MN  C 501 ( 2.3A)
MN  C 501 (-3.1A)
None
 1.21A 4qa2A-2nymC:
undetectable		 4qa2A-2nymC:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 6 CYH C 251
GLY C 207
GLY C 221
ASP C 223
 None
 0.93A 5a06D-2nymC:
undetectable		 5a06D-2nymC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 8 THR C  96
GLY C  90
ALA C 262
HIS C  63
 None
 0.95A 5eevL-2nymC:
undetectable
5eevV-2nymC:
undetectable		 5eevL-2nymC:
13.83
5eevV-2nymC:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 8 THR C  96
GLY C  90
ALA C 262
HIS C  63
 None
 0.94A 5eewL-2nymC:
undetectable
5eewV-2nymC:
undetectable		 5eewL-2nymC:
13.83
5eewV-2nymC:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 8 THR C  96
GLY C  90
ALA C 262
HIS C  63
 None
 0.95A 5ef3L-2nymC:
undetectable
5ef3V-2nymC:
undetectable		 5ef3L-2nymC:
13.83
5ef3V-2nymC:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		5 / 12 LEU C 158
ALA C 157
MET C 276
ILE C 259
GLY C  56
 None
 1.09A 5gs4A-2nymC:
undetectable		 5gs4A-2nymC:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 4 ARG C  89
TYR C 127
HIS C 118
HIS C  59
 None
None
None
MN  C 502 (-3.5A)
 1.49A 5os7A-2nymC:
0.0		 5os7A-2nymC:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		3 / 3 TYR C  86
ALA C 102
LEU C 103
 None
 0.63A 6ag0C-2nymC:
undetectable		 6ag0C-2nymC:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		3 / 3 GLY C  84
ASP C  57
ILE C 259
 None
MN  C 502 ( 3.2A)
None
 0.58A 6dgxB-2nymC:
undetectable		 6dgxB-2nymC:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 4 ARG C  89
TYR C 127
HIS C 118
HIS C  59
 None
None
None
MN  C 502 (-3.5A)
 1.49A 6gmdB-2nymC:
0.0		 6gmdB-2nymC:
21.41