SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nyp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		4 / 8 ASP A  56
HIS A  91
GLY A 167
GLY A 209
 None
ZN  A 302 (-3.2A)
None
ZN  A 302 ( 4.8A)
 0.90A 1ekjA-2nypA:
undetectable
1ekjB-2nypA:
undetectable		 1ekjA-2nypA:
23.32
1ekjB-2nypA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		4 / 7 ASP A  56
HIS A  91
GLY A 167
GLY A 209
 None
ZN  A 302 (-3.2A)
None
ZN  A 302 ( 4.8A)
 0.94A 1ekjE-2nypA:
undetectable
1ekjF-2nypA:
undetectable		 1ekjE-2nypA:
23.32
1ekjF-2nypA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		4 / 8 ASP A  56
HIS A  91
GLY A 167
GLY A 209
 None
ZN  A 302 (-3.2A)
None
ZN  A 302 ( 4.8A)
 0.91A 1ekjG-2nypA:
undetectable
1ekjH-2nypA:
undetectable		 1ekjG-2nypA:
23.32
1ekjH-2nypA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		5 / 10 LEU A 169
GLU A 194
LEU A 223
LEU A 219
LEU A 178
 None
 1.44A 1pcgB-2nypA:
undetectable		 1pcgB-2nypA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		5 / 12 GLY A 166
GLY A 209
VAL A 196
LEU A 164
ILE A 203
 None
ZN  A 302 ( 4.8A)
None
None
None
 0.98A 1zq9B-2nypA:
undetectable		 1zq9B-2nypA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		3 / 3 GLY A 214
GLU A 212
ASP A 215
 None
 0.70A 2b25B-2nypA:
undetectable		 2b25B-2nypA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		4 / 6 GLY A  93
ILE A  95
ILE A  84
ASP A  60
 None
 0.96A 3a7eA-2nypA:
undetectable		 3a7eA-2nypA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		4 / 7 THR A 131
VAL A 140
THR A 142
VAL A 156
 None
 0.47A 3em0B-2nypA:
undetectable		 3em0B-2nypA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_A_ADNA439_1
(ADENOSYLHOMOCYSTEINA
SE)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		5 / 10 LEU A 133
HIS A 106
GLN A 128
THR A 131
GLY A 125
 None
 1.39A 3h9uA-2nypA:
undetectable		 3h9uA-2nypA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		5 / 10 LEU A 133
HIS A 106
GLN A 128
THR A 131
GLY A 125
 None
 1.40A 3h9uC-2nypA:
3.4		 3h9uC-2nypA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		5 / 10 LEU A 133
HIS A 106
GLN A 128
THR A 131
GLY A 125
 None
 1.39A 3h9uD-2nypA:
undetectable		 3h9uD-2nypA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		5 / 10 VAL A 165
GLY A 167
VAL A  82
ASN A  42
GLY A  43
 None
 1.31A 3km6A-2nypA:
undetectable		 3km6A-2nypA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		5 / 12 ILE A 193
LEU A 226
GLY A 209
THR A 222
LEU A 178
 None
None
ZN  A 302 ( 4.8A)
None
None
 0.95A 3uq6A-2nypA:
undetectable		 3uq6A-2nypA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		5 / 12 ILE A 193
LEU A 226
GLY A 209
THR A 222
LEU A 178
 None
None
ZN  A 302 ( 4.8A)
None
None
 0.92A 3vaqA-2nypA:
undetectable		 3vaqA-2nypA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		5 / 12 ILE A 193
LEU A 226
GLY A 209
THR A 222
LEU A 178
 None
None
ZN  A 302 ( 4.8A)
None
None
 0.94A 3vasA-2nypA:
undetectable		 3vasA-2nypA:
18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1D_A_X8ZA350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		5 / 9 HIS A  88
ASP A  90
HIS A 149
ASN A 180
HIS A 210
 ZN  A 301 (-3.1A)
ZN  A 302 (-3.3A)
ZN  A 301 (-3.2A)
None
ZN  A 302 (-4.1A)
 0.63A 4c1dA-2nypA:
32.0		 4c1dA-2nypA:
37.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1D_A_X8ZA350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		5 / 9 TRP A  59
ASP A  90
HIS A 149
ASN A 180
HIS A 210
 None
ZN  A 302 (-3.3A)
ZN  A 301 (-3.2A)
None
ZN  A 302 (-4.1A)
 1.26A 4c1dA-2nypA:
32.0		 4c1dA-2nypA:
37.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		6 / 10 HIS A  86
HIS A  88
ASP A  90
HIS A 149
ASN A 180
HIS A 210
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.1A)
ZN  A 302 (-3.3A)
ZN  A 301 (-3.2A)
None
ZN  A 302 (-4.1A)
 0.61A 4c1dB-2nypA:
32.0		 4c1dB-2nypA:
37.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		6 / 10 TRP A  59
HIS A  86
ASP A  90
HIS A 149
ASN A 180
HIS A 210
 None
ZN  A 301 (-3.3A)
ZN  A 302 (-3.3A)
ZN  A 301 (-3.2A)
None
ZN  A 302 (-4.1A)
 1.16A 4c1dB-2nypA:
32.0		 4c1dB-2nypA:
37.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		6 / 11 HIS A  86
HIS A  88
ASP A  90
HIS A 149
LYS A 171
HIS A 210
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.1A)
ZN  A 302 (-3.3A)
ZN  A 301 (-3.2A)
None
ZN  A 302 (-4.1A)
 0.65A 4c1fA-2nypA:
30.6
4c1fB-2nypA:
29.7		 4c1fA-2nypA:
35.37
4c1fB-2nypA:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		6 / 11 HIS A  86
HIS A  88
HIS A 149
LYS A 171
ASN A 180
HIS A 210
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.1A)
ZN  A 301 (-3.2A)
None
None
ZN  A 302 (-4.1A)
 0.81A 4c1fA-2nypA:
30.6
4c1fB-2nypA:
29.7		 4c1fA-2nypA:
35.37
4c1fB-2nypA:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		7 / 9 TRP A  59
HIS A  86
HIS A  88
ASP A  90
HIS A 149
GLY A 179
HIS A 210
 None
ZN  A 301 (-3.3A)
ZN  A 301 (-3.1A)
ZN  A 302 (-3.3A)
ZN  A 301 (-3.2A)
None
ZN  A 302 (-4.1A)
 0.72A 4c1hA-2nypA:
40.9		 4c1hA-2nypA:
99.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_A_X8ZA301_1
(BETA-LACTAMASE NDM-1)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		6 / 9 VAL A  39
TRP A  59
HIS A  88
ASP A  90
HIS A 149
HIS A 210
 None
None
ZN  A 301 (-3.1A)
ZN  A 302 (-3.3A)
ZN  A 301 (-3.2A)
ZN  A 302 (-4.1A)
 0.72A 4exsA-2nypA:
30.7		 4exsA-2nypA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		7 / 8 VAL A  39
TRP A  59
HIS A  88
ASP A  90
HIS A 149
ASN A 180
HIS A 210
 None
None
ZN  A 301 (-3.1A)
ZN  A 302 (-3.3A)
ZN  A 301 (-3.2A)
None
ZN  A 302 (-4.1A)
 0.82A 4exsB-2nypA:
31.1		 4exsB-2nypA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		5 / 12 HIS A  86
ILE A  84
ASP A 126
LEU A 127
GLY A 125
 ZN  A 301 (-3.3A)
None
None
None
None
 1.19A 4fqsA-2nypA:
undetectable		 4fqsA-2nypA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		5 / 12 HIS A  86
ILE A  84
ASP A 126
LEU A 127
GLY A 125
 ZN  A 301 (-3.3A)
None
None
None
None
 1.17A 4fqsB-2nypA:
undetectable		 4fqsB-2nypA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		5 / 9 LEU A  98
SER A 107
THR A 142
VAL A 140
LEU A 133
 None
 1.44A 4wnvA-2nypA:
undetectable		 4wnvA-2nypA:
18.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		7 / 8 VAL A  39
TRP A  59
HIS A  88
ASP A  90
HIS A 149
ASN A 180
HIS A 210
 None
None
ZN  A 301 (-3.1A)
ZN  A 302 (-3.3A)
ZN  A 301 (-3.2A)
None
ZN  A 302 (-4.1A)
 0.71A 5a5zA-2nypA:
30.9		 5a5zA-2nypA:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		5 / 7 HIS A 149
LYS A 171
GLY A 179
ASN A 180
HIS A 210
 ZN  A 301 (-3.2A)
None
None
None
ZN  A 302 (-4.1A)
 0.53A 5a5zC-2nypA:
30.8		 5a5zC-2nypA:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		4 / 7 HIS A 210
LYS A 171
GLY A 167
HIS A 149
 ZN  A 302 (-4.1A)
None
None
ZN  A 301 (-3.2A)
 1.17A 5a5zC-2nypA:
30.8		 5a5zC-2nypA:
32.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		5 / 11 HIS A  86
HIS A  88
ASP A  90
HIS A  91
HIS A 149
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.1A)
ZN  A 302 (-3.3A)
ZN  A 302 (-3.2A)
ZN  A 301 (-3.2A)
 0.54A 5ayaA-2nypA:
19.6		 5ayaA-2nypA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		5 / 11 HIS A  86
HIS A  88
ASP A  90
HIS A 149
HIS A 210
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.1A)
ZN  A 302 (-3.3A)
ZN  A 301 (-3.2A)
ZN  A 302 (-4.1A)
 0.67A 5ayaA-2nypA:
19.6		 5ayaA-2nypA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		5 / 10 LEU A 169
GLU A 194
LEU A 223
LEU A 219
LEU A 178
 None
 1.43A 5dxeB-2nypA:
undetectable		 5dxeB-2nypA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		3 / 3 LYS A 147
ASP A 152
ILE A 193
 None
 0.87A 5kc4E-2nypA:
undetectable		 5kc4E-2nypA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		5 / 10 HIS A  86
HIS A  88
HIS A  91
HIS A 149
ASP A 168
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.1A)
ZN  A 302 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 302 ( 2.3A)
 0.61A 5nzwA-2nypA:
4.1		 5nzwA-2nypA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		3 / 3 HIS A 210
ASP A 168
HIS A  91
 ZN  A 302 (-4.1A)
ZN  A 302 ( 2.3A)
ZN  A 302 (-3.2A)
 0.81A 5oexA-2nypA:
2.2		 5oexA-2nypA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		4 / 6 VAL A  82
LYS A 104
ILE A  84
LYS A  99
 None
 1.33A 5q1sA-2nypA:
2.8		 5q1sA-2nypA:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		5 / 8 TRP A  59
HIS A  88
ASP A  90
HIS A 149
ASN A 180
 None
ZN  A 301 (-3.1A)
ZN  A 302 (-3.3A)
ZN  A 301 (-3.2A)
None
 0.77A 5zj8A-2nypA:
14.1		 5zj8A-2nypA:
32.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 2nyp BETA-LACTAMASE II
(Bacillus
cereus) 		5 / 8 TRP A  59
HIS A  88
ASP A  90
HIS A 149
HIS A 210
 None
ZN  A 301 (-3.1A)
ZN  A 302 (-3.3A)
ZN  A 301 (-3.2A)
ZN  A 302 (-4.1A)
 0.75A 5zj8A-2nypA:
14.1		 5zj8A-2nypA:
32.27