SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nyt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 2nyt PROBABLE
C->U-EDITING ENZYME
APOBEC-2
(Homo
sapiens) 		3 / 3 VAL A 192
VAL A 187
TRP A 188
 None
 0.97A 1av2C-2nytA:
undetectable
1av2D-2nytA:
undetectable		 1av2C-2nytA:
6.90
1av2D-2nytA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 2nyt PROBABLE
C->U-EDITING ENZYME
APOBEC-2
(Homo
sapiens) 		3 / 3 VAL A 192
VAL A 187
TRP A 188
 None
 0.82A 3l8lA-2nytA:
undetectable
3l8lB-2nytA:
undetectable		 3l8lA-2nytA:
6.90
3l8lB-2nytA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 2nyt PROBABLE
C->U-EDITING ENZYME
APOBEC-2
(Homo
sapiens) 		3 / 3 VAL A 192
VAL A 187
TRP A 188
 None
 0.94A 3l8lC-2nytA:
undetectable
3l8lD-2nytA:
undetectable		 3l8lC-2nytA:
6.90
3l8lD-2nytA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2nyt PROBABLE
C->U-EDITING ENZYME
APOBEC-2
(Homo
sapiens) 		4 / 8 LEU A 139
SER A 140
LEU A 108
ILE A 135
 None
 0.95A 3ln1A-2nytA:
undetectable		 3ln1A-2nytA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2nyt PROBABLE
C->U-EDITING ENZYME
APOBEC-2
(Homo
sapiens) 		4 / 7 LEU A 139
SER A 140
LEU A 108
ILE A 135
 None
 0.93A 3ln1B-2nytA:
undetectable		 3ln1B-2nytA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2nyt PROBABLE
C->U-EDITING ENZYME
APOBEC-2
(Homo
sapiens) 		5 / 12 LEU A 169
ILE A 162
VAL A 119
VAL A 151
GLU A  60
 None
None
None
None
ZN  A2000 (-2.8A)
 1.40A 3w1wB-2nytA:
undetectable		 3w1wB-2nytA:
19.51