SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nyu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EIZ_A_SAMA301_0
(FTSJ)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		8 / 12 GLY A  30
PRO A  33
GLY A  34
TRP A  36
LEU A  63
LEU A  64
LEU A 123
LYS A 144
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.4A)
SAM  A 201 (-3.7A)
SAM  A 201 (-3.9A)
SAM  A 201 (-4.2A)
SAM  A 201 (-4.1A)
None
SAM  A 201 (-3.5A)
 0.57A 1eizA-2nyuA:
26.6		 1eizA-2nyuA:
36.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EIZ_A_SAMA301_1
(FTSJ)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		3 / 3 ASP A  62
ASP A  79
ASP A 104
 SAM  A 201 (-2.8A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.7A)
 0.38A 1eizA-2nyuA:
26.6		 1eizA-2nyuA:
36.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EJ0_A_SAMA301_0
(FTSJ)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		8 / 12 GLY A  30
PRO A  33
GLY A  34
TRP A  36
LEU A  63
LEU A  64
LEU A 123
LYS A 144
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.4A)
SAM  A 201 (-3.7A)
SAM  A 201 (-3.9A)
SAM  A 201 (-4.2A)
SAM  A 201 (-4.1A)
None
SAM  A 201 (-3.5A)
 0.57A 1ej0A-2nyuA:
26.3		 1ej0A-2nyuA:
36.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EJ0_A_SAMA301_1
(FTSJ)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		3 / 3 ASP A  62
ASP A  79
ASP A 104
 SAM  A 201 (-2.8A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.7A)
 0.42A 1ej0A-2nyuA:
26.3		 1ej0A-2nyuA:
36.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		3 / 3 PRO A  33
ASP A  62
ASP A 104
 SAM  A 201 (-3.4A)
SAM  A 201 (-2.8A)
SAM  A 201 (-3.7A)
 0.31A 1sqfA-2nyuA:
11.8		 1sqfA-2nyuA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		6 / 11 GLY A  30
ALA A  32
ASP A  62
LEU A  63
ASP A  79
VAL A  80
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.8A)
SAM  A 201 (-2.8A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
 0.55A 1uayA-2nyuA:
9.1		 1uayA-2nyuA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		3 / 3 ASP A  62
ASP A  79
ASP A 104
 SAM  A 201 (-2.8A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.7A)
 0.70A 2igtA-2nyuA:
12.4		 2igtA-2nyuA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		3 / 3 ASP A  62
ASP A  79
ASP A 104
 SAM  A 201 (-2.8A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.7A)
 0.72A 2igtB-2nyuA:
12.1		 2igtB-2nyuA:
19.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		8 / 12 SER A   4
GLY A  30
ALA A  32
GLY A  34
ALA A  35
LEU A  63
LEU A  64
VAL A  80
 SAM  A 201 ( 4.8A)
SAM  A 201 (-3.5A)
SAM  A 201 (-3.8A)
SAM  A 201 (-3.7A)
SAM  A 201 (-3.2A)
SAM  A 201 (-4.2A)
SAM  A 201 (-4.1A)
SAM  A 201 (-3.9A)
 1.22A 2nyuA-2nyuA:
38.7		 2nyuA-2nyuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		12 / 12 SER A   6
GLY A  30
ALA A  32
GLY A  34
ALA A  35
TRP A  36
LEU A  63
LEU A  64
VAL A  80
MET A 105
LEU A 123
LYS A 144
 SAM  A 201 (-2.5A)
SAM  A 201 (-3.5A)
SAM  A 201 (-3.8A)
SAM  A 201 (-3.7A)
SAM  A 201 (-3.2A)
SAM  A 201 (-3.9A)
SAM  A 201 (-4.2A)
SAM  A 201 (-4.1A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.9A)
None
SAM  A 201 (-3.5A)
 0.45A 2nyuA-2nyuA:
38.7		 2nyuA-2nyuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		4 / 4 PRO A  33
ASP A  62
ASP A  79
ASP A  28
 SAM  A 201 (-3.4A)
SAM  A 201 (-2.8A)
SAM  A 201 (-3.3A)
SAM  A 201 ( 4.8A)
 0.90A 2nyuA-2nyuA:
38.7		 2nyuA-2nyuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		4 / 4 PRO A  33
ASP A  62
ASP A  79
ASP A 104
 SAM  A 201 (-3.4A)
SAM  A 201 (-2.8A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.7A)
 0.00A 2nyuA-2nyuA:
38.7		 2nyuA-2nyuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		8 / 12 SER A   4
GLY A  30
ALA A  32
GLY A  34
LEU A  63
LEU A  64
VAL A  80
THR A  81
 SAM  A 201 ( 4.8A)
SAM  A 201 (-3.5A)
SAM  A 201 (-3.8A)
SAM  A 201 (-3.7A)
SAM  A 201 (-4.2A)
SAM  A 201 (-4.1A)
SAM  A 201 (-3.9A)
SAM  A 201 ( 4.1A)
 1.24A 2nyuB-2nyuA:
35.5		 2nyuB-2nyuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		12 / 12 SER A   6
GLY A  30
ALA A  32
GLY A  34
TRP A  36
LEU A  63
LEU A  64
VAL A  80
THR A  81
MET A 105
LEU A 123
LYS A 144
 SAM  A 201 (-2.5A)
SAM  A 201 (-3.5A)
SAM  A 201 (-3.8A)
SAM  A 201 (-3.7A)
SAM  A 201 (-3.9A)
SAM  A 201 (-4.2A)
SAM  A 201 (-4.1A)
SAM  A 201 (-3.9A)
SAM  A 201 ( 4.1A)
SAM  A 201 (-3.9A)
None
SAM  A 201 (-3.5A)
 0.42A 2nyuB-2nyuA:
35.5		 2nyuB-2nyuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 5 PRO A  33
ALA A  35
ASP A  62
ASP A  79
ASP A 104
 SAM  A 201 (-3.4A)
SAM  A 201 (-3.2A)
SAM  A 201 (-2.8A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.7A)
 0.18A 2nyuB-2nyuA:
35.5		 2nyuB-2nyuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
GLY A  34
TRP A  36
LEU A  63
LYS A 144
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.7A)
SAM  A 201 (-3.9A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.5A)
 0.65A 2oxtB-2nyuA:
14.7		 2oxtB-2nyuA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
LEU A  63
ASP A 104
LYS A 144
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.7A)
SAM  A 201 (-3.5A)
 0.60A 2oxtC-2nyuA:
14.7		 2oxtC-2nyuA:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
PRO A  33
GLY A  34
TRP A  36
LEU A 123
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.4A)
SAM  A 201 (-3.7A)
SAM  A 201 (-3.9A)
None
 0.43A 2plwA-2nyuA:
25.7		 2plwA-2nyuA:
33.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.45A 2pxcA-2nyuA:
14.3		 2pxcA-2nyuA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		6 / 12 GLY A  30
TRP A  36
LEU A  63
ASP A  79
VAL A  80
THR A  81
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 ( 4.1A)
 0.65A 2wa2A-2nyuA:
15.2		 2wa2A-2nyuA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		7 / 12 SER A   4
GLY A  30
TRP A  36
LEU A  63
VAL A  80
THR A  81
ASP A 104
 SAM  A 201 ( 4.8A)
SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.9A)
SAM  A 201 ( 4.1A)
SAM  A 201 (-3.7A)
 0.62A 2wa2B-2nyuA:
14.8		 2wa2B-2nyuA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		6 / 12 GLY A  30
PRO A  33
GLY A  34
TRP A  36
LEU A  63
LYS A 144
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.4A)
SAM  A 201 (-3.7A)
SAM  A 201 (-3.9A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.5A)
 0.31A 3douA-2nyuA:
24.8		 3douA-2nyuA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		3 / 3 ASP A  62
ASP A  79
ASP A 104
 SAM  A 201 (-2.8A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.7A)
 0.34A 3douA-2nyuA:
24.8		 3douA-2nyuA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
LEU A  63
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.47A 3eluA-2nyuA:
14.4		 3eluA-2nyuA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
LEU A  63
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.45A 3elwA-2nyuA:
14.7		 3elwA-2nyuA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
LEU A  63
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.39A 3embA-2nyuA:
14.7		 3embA-2nyuA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		6 / 12 GLY A  30
TRP A  36
LEU A  63
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.52A 3gczA-2nyuA:
14.8		 3gczA-2nyuA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		6 / 12 SER A   4
GLY A  30
TRP A  36
LEU A  63
ASP A  79
ASP A 104
 SAM  A 201 ( 4.8A)
SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.7A)
 0.69A 3gczA-2nyuA:
14.8		 3gczA-2nyuA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.39A 3p97A-2nyuA:
14.1		 3p97A-2nyuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.49A 3p97C-2nyuA:
14.0		 3p97C-2nyuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
LEU A  63
ASP A  79
MET A 105
LYS A 144
 SAM  A 201 (-3.5A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.5A)
 0.66A 3r24A-2nyuA:
12.9		 3r24A-2nyuA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		4 / 7 ILE A 168
LEU A 102
HIS A  17
VAL A  44
 None
 0.97A 3r9vA-2nyuA:
undetectable
3r9vB-2nyuA:
undetectable		 3r9vA-2nyuA:
21.83
3r9vB-2nyuA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		9 / 12 SER A   4
GLY A  30
PRO A  33
GLY A  34
TRP A  36
ASP A  62
ASP A  79
ASP A 104
MET A 105
 SAM  A 201 ( 4.8A)
SAM  A 201 (-3.5A)
SAM  A 201 (-3.4A)
SAM  A 201 (-3.7A)
SAM  A 201 (-3.9A)
SAM  A 201 (-2.8A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.7A)
SAM  A 201 (-3.9A)
 0.63A 4b17A-2nyuA:
14.4		 4b17A-2nyuA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.41A 4ctjA-2nyuA:
14.0		 4ctjA-2nyuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.41A 4ctkA-2nyuA:
14.0		 4ctkA-2nyuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 SER A   4
GLY A  30
TRP A  36
VAL A  80
ASP A 104
 SAM  A 201 ( 4.8A)
SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.76A 4ctkC-2nyuA:
14.0		 4ctkC-2nyuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 PRO A  33
GLY A  34
LEU A  63
ASP A 104
LEU A 123
 SAM  A 201 (-3.4A)
SAM  A 201 (-3.7A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.7A)
None
 0.92A 4fp9A-2nyuA:
9.4		 4fp9A-2nyuA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 PRO A  33
GLY A  34
LEU A  63
ASP A 104
LEU A 123
 SAM  A 201 (-3.4A)
SAM  A 201 (-3.7A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.7A)
None
 0.92A 4fp9C-2nyuA:
9.4		 4fp9C-2nyuA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 PRO A  33
GLY A  34
LEU A  63
ASP A 104
LEU A 123
 SAM  A 201 (-3.4A)
SAM  A 201 (-3.7A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.7A)
None
 0.91A 4fp9F-2nyuA:
9.4		 4fp9F-2nyuA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 PRO A  33
GLY A  34
LEU A  63
ASP A  79
LEU A 123
 SAM  A 201 (-3.4A)
SAM  A 201 (-3.7A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.3A)
None
 1.07A 4fzvA-2nyuA:
8.5		 4fzvA-2nyuA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 PRO A  33
GLY A  34
LEU A  63
THR A  81
LEU A 123
 SAM  A 201 (-3.4A)
SAM  A 201 (-3.7A)
SAM  A 201 (-4.2A)
SAM  A 201 ( 4.1A)
None
 0.69A 4n49A-2nyuA:
15.2		 4n49A-2nyuA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 SER A   4
GLY A  30
ASP A  62
LEU A  63
ASP A  79
 SAM  A 201 ( 4.8A)
SAM  A 201 (-3.5A)
SAM  A 201 (-2.8A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.3A)
 1.30A 4pghB-2nyuA:
9.3		 4pghB-2nyuA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		6 / 12 SER A   6
ASP A  28
GLY A  30
ASP A  62
LEU A  63
ASP A  79
 SAM  A 201 (-2.5A)
SAM  A 201 ( 4.8A)
SAM  A 201 (-3.5A)
SAM  A 201 (-2.8A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.3A)
 0.77A 4pghB-2nyuA:
9.3		 4pghB-2nyuA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 11 SER A   4
GLY A  30
ASP A  62
LEU A  63
ASP A  79
 SAM  A 201 ( 4.8A)
SAM  A 201 (-3.5A)
SAM  A 201 (-2.8A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.3A)
 1.30A 4pghC-2nyuA:
12.1		 4pghC-2nyuA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		3 / 3 ASP A 116
LEU A 115
PHE A 112
 None
 0.47A 4pthA-2nyuA:
2.4		 4pthA-2nyuA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  34
TRP A  36
LEU A  63
THR A  81
LYS A 144
 SAM  A 201 (-3.7A)
SAM  A 201 (-3.9A)
SAM  A 201 (-4.2A)
SAM  A 201 ( 4.1A)
SAM  A 201 (-3.5A)
 1.01A 4uckB-2nyuA:
9.1		 4uckB-2nyuA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.41A 5e9qA-2nyuA:
14.1		 5e9qA-2nyuA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.46A 5e9qC-2nyuA:
14.0		 5e9qC-2nyuA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 SER A   4
GLY A  30
TRP A  36
VAL A  80
ASP A 104
 SAM  A 201 ( 4.8A)
SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.72A 5ec8A-2nyuA:
14.0		 5ec8A-2nyuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.46A 5ec8C-2nyuA:
13.9		 5ec8C-2nyuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.44A 5ehgA-2nyuA:
14.0		 5ehgA-2nyuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.43A 5ehiA-2nyuA:
14.1		 5ehiA-2nyuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.43A 5ehiC-2nyuA:
14.1		 5ehiC-2nyuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.42A 5eifA-2nyuA:
14.0		 5eifA-2nyuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.45A 5eifC-2nyuA:
14.0		 5eifC-2nyuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.44A 5eiwA-2nyuA:
14.0		 5eiwA-2nyuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.48A 5eiwC-2nyuA:
14.0		 5eiwC-2nyuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		6 / 12 SER A   4
GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 ( 4.8A)
SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.69A 5ekxA-2nyuA:
14.1		 5ekxA-2nyuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.34A 5ikmA-2nyuA:
14.0		 5ikmA-2nyuA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.47A 5kqsA-2nyuA:
14.1		 5kqsA-2nyuA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_A_SAMA301_0
(NS5)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.39A 5njvA-2nyuA:
14.1		 5njvA-2nyuA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.46A 5njvB-2nyuA:
14.1		 5njvB-2nyuA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.52A 5njvD-2nyuA:
14.1		 5njvD-2nyuA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		6 / 12 ALA A  32
PRO A  33
ASP A  62
ASP A  79
ASP A 104
LEU A 123
 SAM  A 201 (-3.8A)
SAM  A 201 (-3.4A)
SAM  A 201 (-2.8A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.7A)
None
 0.78A 5wwsA-2nyuA:
10.6		 5wwsA-2nyuA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 ALA A  32
PRO A  33
ASP A  62
ASP A  79
LEU A 123
 SAM  A 201 (-3.8A)
SAM  A 201 (-3.4A)
SAM  A 201 (-2.8A)
SAM  A 201 (-3.3A)
None
 0.58A 5wwsA-2nyuA:
10.6		 5wwsA-2nyuA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 ALA A  32
PRO A  33
ASP A  79
ASP A  28
LEU A 123
 SAM  A 201 (-3.8A)
SAM  A 201 (-3.4A)
SAM  A 201 (-3.3A)
SAM  A 201 ( 4.8A)
None
 1.15A 5wwsA-2nyuA:
10.6		 5wwsA-2nyuA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 ALA A  32
PRO A  33
ASP A  62
ASP A  79
ASP A 104
 SAM  A 201 (-3.8A)
SAM  A 201 (-3.4A)
SAM  A 201 (-2.8A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.7A)
 0.55A 5wwsB-2nyuA:
10.6		 5wwsB-2nyuA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.42A 5wz1A-2nyuA:
14.0		 5wz1A-2nyuA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.43A 5wz1C-2nyuA:
14.0		 5wz1C-2nyuA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.43A 5wz1D-2nyuA:
13.9		 5wz1D-2nyuA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.44A 5wz1E-2nyuA:
14.0		 5wz1E-2nyuA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.45A 5wz1F-2nyuA:
14.0		 5wz1F-2nyuA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.40A 5wz1G-2nyuA:
13.9		 5wz1G-2nyuA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.45A 5wz1H-2nyuA:
14.0		 5wz1H-2nyuA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.50A 5wz2A-2nyuA:
13.9		 5wz2A-2nyuA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
TRP A  36
ASP A  79
VAL A  80
ASP A 104
 SAM  A 201 (-3.5A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.9A)
SAM  A 201 (-3.7A)
 0.44A 5wz2B-2nyuA:
14.0		 5wz2B-2nyuA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A  30
LEU A  63
ASP A  79
ASP A 104
MET A 105
 SAM  A 201 (-3.5A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.7A)
SAM  A 201 (-3.9A)
 0.29A 5yn6A-2nyuA:
12.6		 5yn6A-2nyuA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		6 / 12 GLY A  30
ASP A  62
LEU A  63
ASP A  79
ASP A 104
MET A 105
 SAM  A 201 (-3.5A)
SAM  A 201 (-2.8A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.7A)
SAM  A 201 (-3.9A)
 0.29A 5yniA-2nyuA:
12.6		 5yniA-2nyuA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		6 / 12 GLY A  30
ASP A  62
LEU A  63
ASP A  79
ASP A 104
MET A 105
 SAM  A 201 (-3.5A)
SAM  A 201 (-2.8A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.7A)
SAM  A 201 (-3.9A)
 0.28A 5ynmA-2nyuA:
12.7		 5ynmA-2nyuA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 LEU A 120
ILE A 121
PHE A 141
VAL A  39
LEU A  20
 None
 1.17A 6a7pA-2nyuA:
undetectable		 6a7pA-2nyuA:
17.30