SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nyx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 2nyx PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN,
RV1404
(Mycobacterium
tuberculosis) 		5 / 12 THR A  76
ILE A  53
LEU A  69
ILE A  89
VAL A 113
 None
 1.17A 3a51C-2nyxA:
undetectable		 3a51C-2nyxA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 2nyx PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN,
RV1404
(Mycobacterium
tuberculosis) 		4 / 6 ALA A 142
LEU A 143
ALA A  24
THR A  23
 None
 0.87A 3b6hA-2nyxA:
undetectable		 3b6hA-2nyxA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 2nyx PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN,
RV1404
(Mycobacterium
tuberculosis) 		4 / 6 ALA A 142
LEU A 143
ALA A  24
THR A  23
 None
 0.81A 3b6hB-2nyxA:
undetectable		 3b6hB-2nyxA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 2nyx PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN,
RV1404
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  69
ALA A 103
LEU A  54
LEU A  51
 None
 0.87A 4ubsA-2nyxA:
undetectable		 4ubsA-2nyxA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 2nyx PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN,
RV1404
(Mycobacterium
tuberculosis) 		3 / 3 MET A 131
GLU A 135
LEU A 139
 None
 0.37A 4v2oB-2nyxA:
undetectable		 4v2oB-2nyxA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 2nyx PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN,
RV1404
(Mycobacterium
tuberculosis) 		4 / 7 ILE A  36
GLU A 123
HIS A 119
VAL A 116
 None
 0.93A 6j20A-2nyxA:
undetectable		 6j20A-2nyxA:
16.03