SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nz0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WRL_D_TFPD207_1 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	2nz0	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY D MEMBER 3 (Homo sapiens)	4 / 8	LEU B 44 PHE B 84 PHE B 120 SER B 68	None	1.02A	1wrlC-2nz0B: undetectable 1wrlD-2nz0B: undetectable	1wrlC-2nz0B: 19.12 1wrlD-2nz0B: 19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q8H_A_TF4A438_1 ([PYRUVATE DEHYDROGENASE [LIPOAMIDE]] KINASE ISOZYME 1)	2nz0	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY D MEMBER 3 (Homo sapiens)	4 / 6	LEU B 44 TYR B 82 ILE B 42 ARG B 55	None	0.96A	2q8hA-2nz0B: undetectable	2q8hA-2nz0B: 13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LM8_C_VIBC223_1 (THIAMINE PYROPHOSPHOKINASE)	2nz0	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY D MEMBER 3 (Homo sapiens)	4 / 8	ASP B 115 TYR B 105 LEU B 103 LEU B 118	None	0.98A	3lm8A-2nz0B: undetectable 3lm8C-2nz0B: undetectable	3lm8A-2nz0B: 16.96 3lm8C-2nz0B: 16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HU9_N_PCFN606_0 (CYTOCHROME B)	2nz0	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY D MEMBER 3 (Homo sapiens)	5 / 12	PHE B 120 TYR B 61 PHE B 97 VAL B 94 VAL B 90	None	1.34A	6hu9N-2nz0B: undetectable	6hu9N-2nz0B: 13.23

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1WRL_D_TFPD207_1","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES;TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","2nz0","POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY D MEMBER 3","Homo sapiens",4,"LEU B  44;PHE B  84;PHE B 120;SER B  68","None","1.02A","1wrlC-2nz0B:undetectable;1wrlD-2nz0B:undetectable","1wrlC-2nz0B:19.12;1wrlD-2nz0B:19.12"],["2Q8H_A_TF4A438_1","[PYRUVATE DEHYDROGENASE [LIPOAMIDE]] KINASE ISOZYME 1","2nz0","POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY D MEMBER 3","Homo sapiens",4,"LEU B  44;TYR B  82;ILE B  42;ARG B  55","None","0.96A","2q8hA-2nz0B:undetectable","2q8hA-2nz0B:13.78"],["3LM8_C_VIBC223_1","THIAMINE PYROPHOSPHOKINASE;THIAMINE PYROPHOSPHOKINASE","2nz0","POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY D MEMBER 3","Homo sapiens",4,"ASP B 115;TYR B 105;LEU B 103;LEU B 118","None","0.98A","3lm8A-2nz0B:undetectable;3lm8C-2nz0B:undetectable","3lm8A-2nz0B:16.96;3lm8C-2nz0B:16.96"],["6HU9_N_PCFN606_0","CYTOCHROME B","2nz0","POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY D MEMBER 3","Homo sapiens",5,"PHE B 120;TYR B  61;PHE B  97;VAL B  94;VAL B  90","None","1.34A","6hu9N-2nz0B:undetectable","6hu9N-2nz0B:13.23"]]