SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nz2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 2nz2 ARGININOSUCCINATE
SYNTHASE
(Homo
sapiens) 		4 / 6 SER A  92
LEU A  89
ASP A 124
GLU A 270
 None
None
ASP  A 501 ( 3.6A)
CIR  A 502 (-2.6A)
 1.07A 2j2pE-2nz2A:
undetectable
2j2pF-2nz2A:
undetectable		 2j2pE-2nz2A:
19.47
2j2pF-2nz2A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2nz2 ARGININOSUCCINATE
SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A  38
ALA A  36
ALA A  10
TYR A  34
ARG A  95
 None
 1.20A 2japA-2nz2A:
6.2		 2japA-2nz2A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2nz2 ARGININOSUCCINATE
SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A  38
ALA A  36
ALA A  10
TYR A  34
ARG A  95
 None
 1.26A 2japB-2nz2A:
6.2		 2japB-2nz2A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2nz2 ARGININOSUCCINATE
SYNTHASE
(Homo
sapiens) 		5 / 12 SER A 134
SER A  92
PHE A  72
ILE A  38
LEU A 320
 None
 1.47A 3aocC-2nz2A:
undetectable		 3aocC-2nz2A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)		 2nz2 ARGININOSUCCINATE
SYNTHASE
(Homo
sapiens) 		5 / 12 GLN A 102
HIS A 116
VAL A 114
ILE A 139
VAL A 141
 None
None
None
NA  A 503 ( 4.7A)
None
 0.98A 3fw3B-2nz2A:
undetectable		 3fw3B-2nz2A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 2nz2 ARGININOSUCCINATE
SYNTHASE
(Homo
sapiens) 		4 / 7 VAL A 233
PRO A 232
TYR A 253
GLU A 249
 None
 1.05A 4lb2A-2nz2A:
undetectable		 4lb2A-2nz2A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_B_ACTB202_0
(RETINOL-BINDING
PROTEIN 2)		 2nz2 ARGININOSUCCINATE
SYNTHASE
(Homo
sapiens) 		4 / 7 TYR A 291
LEU A 295
GLN A 311
ARG A 307
 None
 1.40A 4qzuB-2nz2A:
0.0		 4qzuB-2nz2A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 2nz2 ARGININOSUCCINATE
SYNTHASE
(Homo
sapiens) 		5 / 12 HIS A 187
THR A  91
SER A  92
GLY A 280
GLY A 264
 None
CIR  A 502 (-3.7A)
None
None
None
 1.50A 4uinH-2nz2A:
undetectable
4uinL-2nz2A:
undetectable		 4uinH-2nz2A:
18.20
4uinL-2nz2A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2nz2 ARGININOSUCCINATE
SYNTHASE
(Homo
sapiens) 		4 / 6 LEU A 223
ILE A 225
LEU A 254
TYR A 253
 None
 0.84A 4w5nA-2nz2A:
3.4		 4w5nA-2nz2A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2nz2 ARGININOSUCCINATE
SYNTHASE
(Homo
sapiens) 		5 / 7 ILE A 338
CYH A 337
LEU A 313
GLY A 312
GLY A 314
 None
 1.43A 5a06A-2nz2A:
undetectable		 5a06A-2nz2A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2nz2 ARGININOSUCCINATE
SYNTHASE
(Homo
sapiens) 		5 / 7 ILE A 338
CYH A 337
LEU A 313
GLY A 312
GLY A 314
 None
 1.42A 5a06C-2nz2A:
undetectable		 5a06C-2nz2A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2nz2 ARGININOSUCCINATE
SYNTHASE
(Homo
sapiens) 		5 / 7 ILE A 338
CYH A 337
LEU A 313
GLY A 312
GLY A 314
 None
 1.44A 5a06E-2nz2A:
undetectable		 5a06E-2nz2A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2nz2 ARGININOSUCCINATE
SYNTHASE
(Homo
sapiens) 		5 / 7 ILE A 338
CYH A 337
LEU A 313
GLY A 312
GLY A 314
 None
 1.42A 5a06F-2nz2A:
3.3		 5a06F-2nz2A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 2nz2 ARGININOSUCCINATE
SYNTHASE
(Homo
sapiens) 		4 / 5 TYR A 282
ILE A 266
LEU A  93
GLY A  90
 None
 0.72A 5kmdC-2nz2A:
undetectable
5kmdD-2nz2A:
undetectable		 5kmdC-2nz2A:
21.36
5kmdD-2nz2A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2nz2 ARGININOSUCCINATE
SYNTHASE
(Homo
sapiens) 		5 / 10 SER A 131
ARG A  95
ILE A  38
ALA A  94
PHE A 227
 None
 1.45A 5zjiA-2nz2A:
undetectable
5zjiJ-2nz2A:
undetectable		 5zjiA-2nz2A:
11.99
5zjiJ-2nz2A:
5.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 2nz2 ARGININOSUCCINATE
SYNTHASE
(Homo
sapiens) 		4 / 4 HIS A 327
VAL A 103
LEU A 135
ALA A  99
 None
 1.29A 6d8pB-2nz2A:
4.9		 6d8pB-2nz2A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2nz2 ARGININOSUCCINATE
SYNTHASE
(Homo
sapiens) 		4 / 8 TRP A 145
ASP A 124
ARG A 272
GLU A 196
 None
ASP  A 501 ( 3.6A)
ASP  A 501 ( 4.6A)
None
 1.21A 6mn4D-2nz2A:
undetectable		 6mn4D-2nz2A:
21.98