SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nz4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 2nz4 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A
(Homo
sapiens) 		5 / 12 ILE A  93
SER A  91
ILE A  94
LEU A  41
ILE A  43
 None
A  P  17 ( 2.8A)
None
None
None
 1.04A 2nnhA-2nz4A:
undetectable		 2nnhA-2nz4A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2nz4 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A
(Homo
sapiens) 		5 / 8 ILE A  12
ALA A  55
LEU A  17
ILE A  84
PHE A  34
 None
 1.28A 2w9sE-2nz4A:
undetectable		 2w9sE-2nz4A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2nz4 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A
(Homo
sapiens) 		5 / 12 ILE A  21
LEU A  30
ALA A  32
ILE A  33
PHE A  77
 None
 0.97A 3b2rA-2nz4A:
undetectable		 3b2rA-2nz4A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2nz4 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A
(Homo
sapiens) 		5 / 11 ILE A  21
LEU A  30
ALA A  32
ILE A  33
PHE A  77
 None
 0.94A 3b2rB-2nz4A:
undetectable		 3b2rB-2nz4A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2nz4 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A
(Homo
sapiens) 		4 / 6 PHE A  77
MET A  82
ILE A  33
VAL A  45
 None
 1.04A 4mk4B-2nz4A:
undetectable		 4mk4B-2nz4A:
12.79