SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nzc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LN1_A_CELA682_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2nzc	HYPOTHETICAL PROTEIN (Thermotoga maritima)	5 / 12	LEU A 51 VAL A 73 GLY A 68 SER A 64 LEU A 63	None	0.97A	3ln1A-2nzcA: undetectable	3ln1A-2nzcA: 10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LN1_B_CELB682_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2nzc	HYPOTHETICAL PROTEIN (Thermotoga maritima)	5 / 12	LEU A 51 VAL A 73 GLY A 68 SER A 64 LEU A 63	None	0.98A	3ln1B-2nzcA: undetectable	3ln1B-2nzcA: 10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LN1_C_CELC682_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2nzc	HYPOTHETICAL PROTEIN (Thermotoga maritima)	5 / 12	LEU A 51 VAL A 73 GLY A 68 SER A 64 LEU A 63	None	0.98A	3ln1C-2nzcA: undetectable	3ln1C-2nzcA: 10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NT1_B_NPSB4_1 (PROSTAGLANDIN-ENDOPE ROXIDE SYNTHASE 2)	2nzc	HYPOTHETICAL PROTEIN (Thermotoga maritima)	5 / 12	LEU A 51 VAL A 73 GLY A 68 SER A 64 LEU A 63	None	1.02A	3nt1B-2nzcA: undetectable	3nt1B-2nzcA: 10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RR3_A_FLRA700_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2nzc	HYPOTHETICAL PROTEIN (Thermotoga maritima)	5 / 12	LEU A 51 VAL A 73 GLY A 68 SER A 64 LEU A 63	None	1.05A	3rr3A-2nzcA: undetectable	3rr3A-2nzcA: 10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RR3_B_FLRB700_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2nzc	HYPOTHETICAL PROTEIN (Thermotoga maritima)	5 / 12	LEU A 51 VAL A 73 GLY A 68 SER A 64 LEU A 63	None	1.04A	3rr3B-2nzcA: undetectable	3rr3B-2nzcA: 10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FO4_A_MOAA502_1 (INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE)	2nzc	HYPOTHETICAL PROTEIN (Thermotoga maritima)	4 / 8	ASP A 58 ASN A 57 THR A 77 GLY A 65	None	0.93A	4fo4A-2nzcA: undetectable	4fo4A-2nzcA: 13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JW1_A_CELA602_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2nzc	HYPOTHETICAL PROTEIN (Thermotoga maritima)	5 / 12	LEU A 51 VAL A 73 GLY A 68 SER A 64 LEU A 63	None	1.07A	5jw1A-2nzcA: undetectable	5jw1A-2nzcA: 10.22

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3LN1_A_CELA682_1","PROSTAGLANDIN G\/H SYNTHASE 2","2nzc","HYPOTHETICAL PROTEIN","Thermotoga maritima",5,"LEU A  51;VAL A  73;GLY A  68;SER A  64;LEU A  63","None","0.97A","3ln1A-2nzcA:undetectable","3ln1A-2nzcA:10.31"],["3LN1_B_CELB682_1","PROSTAGLANDIN G\/H SYNTHASE 2","2nzc","HYPOTHETICAL PROTEIN","Thermotoga maritima",5,"LEU A  51;VAL A  73;GLY A  68;SER A  64;LEU A  63","None","0.98A","3ln1B-2nzcA:undetectable","3ln1B-2nzcA:10.31"],["3LN1_C_CELC682_1","PROSTAGLANDIN G\/H SYNTHASE 2","2nzc","HYPOTHETICAL PROTEIN","Thermotoga maritima",5,"LEU A  51;VAL A  73;GLY A  68;SER A  64;LEU A  63","None","0.98A","3ln1C-2nzcA:undetectable","3ln1C-2nzcA:10.31"],["3NT1_B_NPSB4_1","PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE 2","2nzc","HYPOTHETICAL PROTEIN","Thermotoga maritima",5,"LEU A  51;VAL A  73;GLY A  68;SER A  64;LEU A  63","None","1.02A","3nt1B-2nzcA:undetectable","3nt1B-2nzcA:10.31"],["3RR3_A_FLRA700_1","PROSTAGLANDIN G\/H SYNTHASE 2","2nzc","HYPOTHETICAL PROTEIN","Thermotoga maritima",5,"LEU A  51;VAL A  73;GLY A  68;SER A  64;LEU A  63","None","1.05A","3rr3A-2nzcA:undetectable","3rr3A-2nzcA:10.45"],["3RR3_B_FLRB700_1","PROSTAGLANDIN G\/H SYNTHASE 2","2nzc","HYPOTHETICAL PROTEIN","Thermotoga maritima",5,"LEU A  51;VAL A  73;GLY A  68;SER A  64;LEU A  63","None","1.04A","3rr3B-2nzcA:undetectable","3rr3B-2nzcA:10.45"],["4FO4_A_MOAA502_1","INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE","2nzc","HYPOTHETICAL PROTEIN","Thermotoga maritima",4,"ASP A  58;ASN A  57;THR A  77;GLY A  65","None","0.93A","4fo4A-2nzcA:undetectable","4fo4A-2nzcA:13.11"],["5JW1_A_CELA602_1","PROSTAGLANDIN G\/H SYNTHASE 2","2nzc","HYPOTHETICAL PROTEIN","Thermotoga maritima",5,"LEU A  51;VAL A  73;GLY A  68;SER A  64;LEU A  63","None","1.07A","5jw1A-2nzcA:undetectable","5jw1A-2nzcA:10.22"]]