SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nzi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2nzi TITIN
(Homo
sapiens) 		4 / 7 VAL A 150
LEU A 159
SER A 158
VAL A 175
 None
 0.87A 3hs6B-2nziA:
undetectable		 3hs6B-2nziA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 2nzi TITIN
(Homo
sapiens) 		4 / 8 ASP A 169
GLY A 116
PRO A 162
GLN A 149
 None
 0.94A 3s3mA-2nziA:
undetectable		 3s3mA-2nziA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 2nzi TITIN
(Homo
sapiens) 		4 / 8 ASP A 169
GLY A 116
PRO A 162
GLN A 149
 None
 1.02A 3s3nA-2nziA:
undetectable		 3s3nA-2nziA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 2nzi TITIN
(Homo
sapiens) 		5 / 9 ARG A 249
ALA A 270
ASP A 197
GLY A 275
ILE A 227
 None
 1.20A 4ll3B-2nziA:
undetectable		 4ll3B-2nziA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 2nzi TITIN
(Homo
sapiens) 		4 / 5 LEU A  11
ALA A  89
LEU A  91
VAL A  76
 None
 1.00A 5cr1A-2nziA:
2.7		 5cr1A-2nziA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2nzi TITIN
(Homo
sapiens) 		4 / 6 LEU A 214
VAL A 255
LEU A 258
VAL A 245
 None
 0.85A 5x7zA-2nziA:
undetectable		 5x7zA-2nziA:
21.81