SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nzj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 2nzj GTP-BINDING PROTEIN
REM 1
(Homo
sapiens) 		4 / 6 PHE A 100
GLU A 237
LEU A 235
VAL A 158
 None
 0.95A 1hk1A-2nzjA:
undetectable		 1hk1A-2nzjA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 2nzj GTP-BINDING PROTEIN
REM 1
(Homo
sapiens) 		4 / 7 PHE A 100
GLU A 237
LEU A 235
VAL A 158
 None
 0.84A 1hk2A-2nzjA:
undetectable		 1hk2A-2nzjA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 2nzj GTP-BINDING PROTEIN
REM 1
(Homo
sapiens) 		4 / 7 PHE A 100
GLU A 237
LEU A 235
VAL A 158
 None
 0.92A 1hk3A-2nzjA:
undetectable		 1hk3A-2nzjA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2nzj GTP-BINDING PROTEIN
REM 1
(Homo
sapiens) 		5 / 10 VAL A 188
GLN A 242
LEU A  86
VAL A  84
LEU A 179
 None
 1.01A 3gwxA-2nzjA:
undetectable		 3gwxA-2nzjA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2nzj GTP-BINDING PROTEIN
REM 1
(Homo
sapiens) 		3 / 3 GLY A  90
GLY A  92
THR A  94
 GDP  A1001 (-3.7A)
GDP  A1001 (-3.2A)
MG  A 252 ( 3.1A)
 0.46A 3si7B-2nzjA:
undetectable		 3si7B-2nzjA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 2nzj GTP-BINDING PROTEIN
REM 1
(Homo
sapiens) 		5 / 9 LEU A 228
VAL A 232
GLY A 194
ILE A 163
THR A 227
 None
None
None
None
GDP  A1001 (-3.3A)
 1.31A 3spkA-2nzjA:
undetectable		 3spkA-2nzjA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 2nzj GTP-BINDING PROTEIN
REM 1
(Homo
sapiens) 		3 / 3 VAL A 133
GLN A 147
CYH A 150
 None
 0.76A 5icxC-2nzjA:
undetectable
5icxF-2nzjA:
undetectable		 5icxC-2nzjA:
21.03
5icxF-2nzjA:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2nzj GTP-BINDING PROTEIN
REM 1
(Homo
sapiens) 		3 / 3 LEU A 175
GLN A 178
LYS A  93
 None
None
GDP  A1001 (-3.0A)
 0.96A 6exiB-2nzjA:
4.0		 6exiB-2nzjA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2nzj GTP-BINDING PROTEIN
REM 1
(Homo
sapiens) 		3 / 3 LEU A 175
GLN A 178
LYS A  93
 None
None
GDP  A1001 (-3.0A)
 0.94A 6exiA-2nzjA:
3.9		 6exiA-2nzjA:
21.82