SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nzt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		4 / 8 LEU A 427
VAL A 412
GLY A 411
MET A 214
 None
 0.95A 1hrkA-2nztA:
2.4		 1hrkA-2nztA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		4 / 8 LEU A 427
VAL A 412
GLY A 411
MET A 214
 None
 0.94A 1hrkB-2nztA:
1.6		 1hrkB-2nztA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		4 / 4 HIS A 420
VAL A 416
THR A 380
LEU A 385
 None
 1.45A 1oq5A-2nztA:
undetectable		 1oq5A-2nztA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		5 / 11 PHE A 293
SER A 234
PHE A 423
LEU A 427
VAL A 431
 None
 1.08A 1q23L-2nztA:
undetectable		 1q23L-2nztA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		3 / 3 MET A 491
ASN A 683
GLN A 739
 None
GLC  A1003 (-3.6A)
GLC  A1003 (-4.3A)
 0.82A 1xoqB-2nztA:
undetectable		 1xoqB-2nztA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		5 / 12 ALA A 391
ALA A 392
GLN A 395
LEU A 434
ILE A 273
 None
 0.91A 2aclA-2nztA:
undetectable
2aclE-2nztA:
undetectable		 2aclA-2nztA:
13.97
2aclE-2nztA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		4 / 8 ASP A 720
LEU A 718
LEU A 479
LEU A 484
 None
 0.99A 2bfpC-2nztA:
undetectable		 2bfpC-2nztA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		3 / 3 SER A 155
ASP A 413
CYH A 217
 BG6  A1002 ( 3.4A)
BG6  A1002 (-2.6A)
None
 1.13A 2br4E-2nztA:
undetectable		 2br4E-2nztA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		3 / 3 ARG A  69
ASP A 164
ASP A 202
 None
 0.74A 2ejtA-2nztA:
undetectable		 2ejtA-2nztA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2N27_A_4DYA205_1
(CALMODULIN)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		5 / 11 ILE A 745
MET A 491
MET A 495
VAL A 659
MET A 662
 None
 1.41A 2n27A-2nztA:
0.0		 2n27A-2nztA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		4 / 8 LEU A 427
VAL A 412
GLY A 411
MET A 214
 None
 0.85A 2po5A-2nztA:
2.2		 2po5A-2nztA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		4 / 8 LEU A 427
VAL A 412
GLY A 411
MET A 214
 None
 0.85A 2po5B-2nztA:
2.2		 2po5B-2nztA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		4 / 6 SER A 269
PHE A 264
ASP A 267
GLU A  38
 None
None
UNX  A   1 (-3.2A)
None
 1.23A 2vn1B-2nztA:
undetectable		 2vn1B-2nztA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		3 / 3 SER A 155
HIS A 129
ASP A 117
 BG6  A1002 ( 3.4A)
None
None
 0.73A 2wa2B-2nztA:
undetectable		 2wa2B-2nztA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		4 / 6 LEU A 833
GLY A 837
LEU A 479
SER A 480
 None
 0.84A 3aiaA-2nztA:
undetectable		 3aiaA-2nztA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		4 / 8 SER A 382
VAL A 378
THR A 336
VAL A 306
 None
 1.00A 3fhxB-2nztA:
undetectable		 3fhxB-2nztA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		4 / 7 GLN A 478
VAL A 825
ILE A 818
GLN A 471
 None
None
UNX  A  10 ( 4.8A)
None
 0.92A 3fi0P-2nztA:
undetectable		 3fi0P-2nztA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		4 / 4 ARG A 190
ASP A  84
GLY A 212
THR A 457
 None
BG6  A1002 ( 2.8A)
None
None
 1.12A 3k4vB-2nztA:
undetectable		 3k4vB-2nztA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		3 / 3 SER A 122
GLY A 123
THR A 124
 None
 0.17A 3k9wA-2nztA:
undetectable		 3k9wA-2nztA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		5 / 11 PHE A 712
LEU A 718
GLU A 486
PHE A 721
LEU A 833
 None
 1.48A 3o94A-2nztA:
undetectable		 3o94A-2nztA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		3 / 4 SER A 733
GLY A 710
GLU A 494
 None
 0.69A 3raeA-2nztA:
undetectable
3raeC-2nztA:
undetectable		 3raeA-2nztA:
21.41
3raeC-2nztA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		3 / 3 SER A 746
ASP A 726
ASP A 720
 None
 0.84A 3uj7A-2nztA:
undetectable		 3uj7A-2nztA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		4 / 6 GLY A 250
ARG A  69
ILE A 245
VAL A 248
 UNX  A1009 ( 4.1A)
None
UNX  A1009 ( 4.6A)
UNX  A1009 (-4.9A)
 1.16A 4e1vF-2nztA:
undetectable		 4e1vF-2nztA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		5 / 11 ALA A 836
ALA A 840
ALA A 839
VAL A 858
LEU A 676
 None
 1.15A 4j6cA-2nztA:
undetectable		 4j6cA-2nztA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		5 / 10 ALA A 836
ALA A 840
ALA A 839
VAL A 858
LEU A 676
 None
 1.15A 4j6cB-2nztA:
undetectable		 4j6cB-2nztA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		5 / 12 ALA A 836
ALA A 840
ALA A 839
VAL A 858
LEU A 676
 None
 1.10A 4j6dA-2nztA:
undetectable		 4j6dA-2nztA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		5 / 12 ALA A 836
ALA A 840
ALA A 839
VAL A 858
LEU A 676
 None
 1.12A 4j6dB-2nztA:
undetectable		 4j6dB-2nztA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		5 / 12 ALA A 836
ALA A 840
ALA A 839
VAL A 858
LEU A 676
 None
 1.12A 4jbtA-2nztA:
undetectable		 4jbtA-2nztA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		5 / 11 ALA A 836
ALA A 840
ALA A 839
VAL A 858
LEU A 676
 None
 1.13A 4jbtB-2nztA:
undetectable		 4jbtB-2nztA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		3 / 3 PHE A 768
THR A 824
LEU A 804
 None
 0.71A 4qztA-2nztA:
undetectable		 4qztA-2nztA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		5 / 9 VAL A 659
GLY A 900
ALA A 902
THR A 905
VAL A 655
 None
 1.04A 4r21B-2nztA:
undetectable		 4r21B-2nztA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		5 / 10 THR A 172
ILE A 229
ASN A 208
LEU A 168
LEU A  85
 GLC  A1001 (-2.7A)
GLC  A1001 (-4.2A)
GLC  A1001 ( 3.0A)
None
None
 1.49A 4r3aB-2nztA:
undetectable		 4r3aB-2nztA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		4 / 7 ILE A 189
PHE A 154
LEU A  85
LEU A 126
 None
 0.74A 4rmjA-2nztA:
undetectable		 4rmjA-2nztA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		4 / 6 ARG A 190
GLN A 194
ILE A 201
ASP A 200
 None
 1.17A 4w5qA-2nztA:
3.7		 4w5qA-2nztA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		4 / 6 ARG A 190
GLN A 194
ILE A 201
ASP A 200
 None
 1.15A 4w5tA-2nztA:
3.9		 4w5tA-2nztA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		4 / 6 ARG A 190
GLN A 194
ILE A 201
ASP A 200
 None
 1.19A 4z4cA-2nztA:
3.8		 4z4cA-2nztA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJQ_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		5 / 12 ASN A 109
MET A 119
ILE A 114
PHE A 175
ASP A 413
 None
None
None
None
BG6  A1002 (-2.6A)
 1.47A 4zjqD-2nztA:
0.0		 4zjqD-2nztA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		4 / 4 VAL A 393
ILE A 257
ASN A 235
VAL A  61
 None
None
GLC  A1001 (-3.6A)
UNX  A   4 (-4.1A)
 1.22A 5ajqA-2nztA:
undetectable		 5ajqA-2nztA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		4 / 4 LEU A 188
ILE A 189
GLY A 123
ILE A 130
 None
 0.84A 5dzk3-2nztA:
undetectable
5dzkm-2nztA:
2.3		 5dzk3-2nztA:
8.70
5dzkm-2nztA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		4 / 8 LEU A 804
PHE A 782
ILE A 781
THR A 762
 None
 0.65A 5eseA-2nztA:
undetectable		 5eseA-2nztA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		5 / 12 ILE A 229
ALA A 236
GLY A 448
GLY A 411
GLY A  87
 GLC  A1001 (-4.2A)
None
BG6  A1002 (-3.6A)
None
UNX  A   6 ( 3.4A)
 0.98A 5i73A-2nztA:
undetectable		 5i73A-2nztA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		5 / 12 VAL A  97
GLU A  76
LEU A  93
ALA A 454
GLY A 218
 None
 1.19A 5m5cB-2nztA:
undetectable		 5m5cB-2nztA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		5 / 12 ALA A  59
GLY A  50
LYS A  62
GLU A  48
GLU A 241
 UNX  A   4 (-3.3A)
UNX  A   4 ( 4.6A)
None
None
None
 1.20A 5nwuA-2nztA:
undetectable		 5nwuA-2nztA:
3.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		5 / 12 ALA A  82
ILE A 189
CYH A 133
ASP A 200
PHE A 199
 None
 1.15A 5vlmA-2nztA:
undetectable		 5vlmA-2nztA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		5 / 8 THR A 570
GLY A 571
CYH A 628
GLY A 627
GLU A 629
 None
 1.21A 5vw9A-2nztA:
2.2		 5vw9A-2nztA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		5 / 12 GLY A 179
VAL A 180
PHE A 154
THR A 172
GLY A 174
 None
None
None
GLC  A1001 (-2.7A)
None
 1.12A 6brdB-2nztA:
undetectable		 6brdB-2nztA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		4 / 6 ARG A 190
GLN A 194
ILE A 201
ASP A 200
 None
 1.18A 6cbdA-2nztA:
3.8		 6cbdA-2nztA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		4 / 7 ALA A 236
GLY A 227
GLY A 231
CYH A 386
 None
None
BG6  A1002 (-3.5A)
None
 0.76A 6nm4A-2nztA:
undetectable		 6nm4A-2nztA:
11.24