SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nzu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 9 VAL G 142
VAL G 127
ILE G  66
SER G 147
LEU G 144
 None
 1.19A 1eqgA-2nzuG:
undetectable		 1eqgA-2nzuG:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
megaterium;
Bacillus
megaterium) 		5 / 10 GLY G 298
MET L  51
VAL G 300
ILE L  47
GLY G  81
 None
None
None
SEP  L  46 ( 4.2A)
None
 1.23A 1fohA-2nzuG:
undetectable		 1fohA-2nzuG:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
megaterium;
Bacillus
megaterium) 		5 / 10 GLY G 298
MET L  51
VAL G 300
ILE L  47
GLY G  81
 None
None
None
SEP  L  46 ( 4.2A)
None
 1.24A 1fohB-2nzuG:
undetectable		 1fohB-2nzuG:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
megaterium;
Bacillus
megaterium) 		5 / 10 GLY G 298
MET L  51
VAL G 300
ILE L  47
GLY G  81
 None
None
None
SEP  L  46 ( 4.2A)
None
 1.25A 1fohD-2nzuG:
undetectable		 1fohD-2nzuG:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 11 ALA G 145
HIS G 131
ILE G 121
SER G 147
ALA G 146
 None
 1.18A 1gtnM-2nzuG:
undetectable
1gtnN-2nzuG:
undetectable		 1gtnM-2nzuG:
15.10
1gtnN-2nzuG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
megaterium;
Bacillus
megaterium) 		5 / 10 GLY G 298
MET L  51
VAL G 300
ILE L  47
GLY G  81
 None
None
None
SEP  L  46 ( 4.2A)
None
 1.21A 1pn0A-2nzuG:
undetectable		 1pn0A-2nzuG:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_B_IPHB6022_0
(PHENOL
2-MONOOXYGENASE)		 2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
megaterium;
Bacillus
megaterium) 		5 / 10 GLY G 298
MET L  51
VAL G 300
ILE L  47
GLY G  81
 None
None
None
SEP  L  46 ( 4.2A)
None
 1.22A 1pn0B-2nzuG:
undetectable		 1pn0B-2nzuG:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
megaterium;
Bacillus
megaterium) 		5 / 10 GLY G 298
MET L  51
VAL G 300
ILE L  47
GLY G  81
 None
None
None
SEP  L  46 ( 4.2A)
None
 1.25A 1pn0D-2nzuG:
undetectable		 1pn0D-2nzuG:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		4 / 8 PHE G 122
GLU G 105
GLN G 100
TYR G  75
 None
 1.36A 2aoxA-2nzuG:
2.4		 2aoxA-2nzuG:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
megaterium;
Bacillus
megaterium) 		3 / 3 SER L  12
GLU G  77
ASP G  84
 SO4  L 975 (-4.0A)
None
None
 0.88A 2avdB-2nzuL:
undetectable		 2avdB-2nzuL:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		4 / 6 LEU G  78
MET G 112
ILE G  66
MET G 302
 None
 1.16A 2hyyC-2nzuG:
undetectable		 2hyyC-2nzuG:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		4 / 7 ALA G 165
ALA G 164
ALA G 168
GLN G 292
 None
 0.81A 3a2qA-2nzuG:
undetectable		 3a2qA-2nzuG:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 10 GLU G 162
GLY G 246
ALA G 251
PHE G 244
LEU G 172
 None
 1.32A 3a3yA-2nzuG:
3.0		 3a3yA-2nzuG:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		3 / 3 LEU G 209
PRO G 210
LEU G 204
 None
 0.48A 3hcrA-2nzuG:
4.6		 3hcrA-2nzuG:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
megaterium;
Bacillus
megaterium) 		6 / 11 GLY G 298
THR L  20
ALA G 145
ASP G 296
ILE G 297
GLN G 292
 None
 1.46A 3id5B-2nzuG:
undetectable		 3id5B-2nzuG:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
megaterium;
Bacillus
megaterium) 		6 / 11 GLY G 298
THR L  20
ALA G 145
ASP G 296
ILE G 297
GLN G 292
 None
 1.46A 3id5F-2nzuG:
undetectable		 3id5F-2nzuG:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
megaterium;
Bacillus
megaterium) 		6 / 12 GLY G 298
THR L  20
ALA G 145
ASP G 296
ILE G 297
GLN G 292
 None
 1.44A 3id6C-2nzuG:
undetectable		 3id6C-2nzuG:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
megaterium;
Bacillus
megaterium) 		5 / 12 ILE G  82
GLY G  81
ARG L  17
ALA L  16
ASP G  84
 None
 0.96A 3jb1A-2nzuG:
undetectable		 3jb1A-2nzuG:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
megaterium;
Bacillus
megaterium) 		5 / 12 ILE G  82
GLY G  81
ARG L  17
ASP G  84
ALA G  76
 None
 1.05A 3jb1A-2nzuG:
undetectable		 3jb1A-2nzuG:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		4 / 5 LEU G 279
THR G 277
GLU G 249
HIS G 256
 None
BG6  G1092 (-3.6A)
BG6  G1092 (-4.7A)
None
 1.19A 3n58C-2nzuG:
4.9		 3n58C-2nzuG:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 12 GLU G  77
GLY G 298
ALA G 145
ASP G 296
GLN G 292
 None
 1.30A 3nmuA-2nzuG:
undetectable
3nmuF-2nzuG:
undetectable		 3nmuA-2nzuG:
22.62
3nmuF-2nzuG:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 12 PRO G 240
LEU G 209
LEU G 172
ILE G 173
ILE G 216
 None
 1.07A 3vrmA-2nzuG:
undetectable		 3vrmA-2nzuG:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 12 GLY G 226
ILE G 227
SER G 184
VAL G 183
ILE G 243
 None
 0.89A 4ax8A-2nzuG:
3.3		 4ax8A-2nzuG:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 12 GLY G 226
ILE G 227
SER G 184
VAL G 183
ILE G 243
 None
 0.85A 4azvA-2nzuG:
3.4		 4azvA-2nzuG:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 12 LEU G 233
VAL G 254
GLY G 257
ALA G 258
LEU G 263
 None
 1.15A 4coxC-2nzuG:
undetectable		 4coxC-2nzuG:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
megaterium;
Bacillus
megaterium) 		5 / 11 ALA L  16
ASP G 296
SER L  52
PHE L  37
VAL L  23
 None
 1.45A 4eilA-2nzuL:
undetectable		 4eilA-2nzuL:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
megaterium;
Bacillus
megaterium) 		5 / 10 ALA L  16
ASP G 296
SER L  52
PHE L  37
LEU L  35
 None
 1.35A 4eilB-2nzuL:
undetectable		 4eilB-2nzuL:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
megaterium;
Bacillus
megaterium) 		5 / 10 ALA L  16
ASP G 296
SER L  52
PHE L  37
VAL L  23
 None
 1.50A 4eilB-2nzuL:
undetectable		 4eilB-2nzuL:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
megaterium;
Bacillus
megaterium) 		5 / 11 ALA L  16
ASP G 296
SER L  52
PHE L  37
VAL L  23
 None
 1.46A 4eilC-2nzuL:
undetectable		 4eilC-2nzuL:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
megaterium) 		4 / 6 ARG G  80
GLY G  81
GLU G  77
GLN L  24
 None
 1.05A 4g0vB-2nzuG:
2.9		 4g0vB-2nzuG:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
megaterium) 		4 / 6 ARG L  17
GLY G  81
GLU G  77
GLN L  24
 None
 1.30A 4g0vB-2nzuL:
undetectable		 4g0vB-2nzuL:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
megaterium;
Bacillus
megaterium) 		5 / 10 ALA L  16
ASP G 296
SER L  52
PHE L  37
VAL L  23
 None
 1.49A 4kyaC-2nzuL:
undetectable		 4kyaC-2nzuL:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		4 / 6 ASP G  99
ASP G  69
ASN G  72
ALA G  76
 None
None
BG6  G1092 (-3.7A)
None
 1.06A 4mdaA-2nzuG:
undetectable		 4mdaA-2nzuG:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 12 MET G 112
LEU G 109
VAL G 142
MET G 309
THR G 306
 None
 1.34A 4mubA-2nzuG:
undetectable		 4mubA-2nzuG:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		3 / 3 ASP G 315
VAL G 319
LEU G 304
 None
 0.42A 5e5jB-2nzuG:
undetectable		 5e5jB-2nzuG:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
megaterium;
Bacillus
megaterium) 		4 / 6 ALA L  19
THR L  20
VAL L  23
VAL G 300
 None
 0.83A 5eclA-2nzuL:
undetectable		 5eclA-2nzuL:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
megaterium;
Bacillus
megaterium) 		4 / 6 ALA L  19
THR L  20
VAL L  23
VAL G 300
 None
 0.75A 5eclD-2nzuL:
undetectable		 5eclD-2nzuL:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
megaterium;
Bacillus
megaterium) 		4 / 6 ILE G  85
ALA L  19
THR L  20
VAL L  23
 None
 0.84A 5eclD-2nzuG:
undetectable		 5eclD-2nzuG:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
megaterium;
Bacillus
megaterium) 		4 / 8 ILE G  85
ALA L  19
THR L  20
VAL L  23
 None
 0.75A 5ecnD-2nzuG:
2.5		 5ecnD-2nzuG:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 10 SER G 147
ALA G 146
ALA G 145
HIS G 131
ILE G 121
 None
 1.17A 5eeuF-2nzuG:
undetectable
5eeuG-2nzuG:
undetectable		 5eeuF-2nzuG:
15.10
5eeuG-2nzuG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 10 ALA G 145
HIS G 131
ILE G 121
SER G 147
ALA G 146
 None
 1.20A 5eeuO-2nzuG:
undetectable
5eeuP-2nzuG:
undetectable		 5eeuO-2nzuG:
15.10
5eeuP-2nzuG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 10 ALA G 145
HIS G 131
ILE G 121
SER G 147
ALA G 146
 None
 1.20A 5eeuQ-2nzuG:
undetectable
5eeuR-2nzuG:
undetectable		 5eeuQ-2nzuG:
15.10
5eeuR-2nzuG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 10 SER G 147
ALA G 146
ALA G 145
HIS G 131
ILE G 121
 None
 1.17A 5eevF-2nzuG:
undetectable
5eevG-2nzuG:
undetectable		 5eevF-2nzuG:
15.10
5eevG-2nzuG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 10 ALA G 145
HIS G 131
ILE G 121
SER G 147
ALA G 146
 None
 1.20A 5eevO-2nzuG:
undetectable
5eevP-2nzuG:
undetectable		 5eevO-2nzuG:
15.10
5eevP-2nzuG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 10 ALA G 145
HIS G 131
ILE G 121
SER G 147
ALA G 146
 None
 1.19A 5eevQ-2nzuG:
undetectable
5eevR-2nzuG:
undetectable		 5eevQ-2nzuG:
15.10
5eevR-2nzuG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 10 SER G 147
ALA G 146
ALA G 145
HIS G 131
ILE G 121
 None
 1.17A 5eewF-2nzuG:
undetectable
5eewG-2nzuG:
undetectable		 5eewF-2nzuG:
15.10
5eewG-2nzuG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 10 ALA G 145
HIS G 131
ILE G 121
SER G 147
ALA G 146
 None
 1.20A 5eewO-2nzuG:
undetectable
5eewP-2nzuG:
undetectable		 5eewO-2nzuG:
15.10
5eewP-2nzuG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 10 ALA G 145
HIS G 131
ILE G 121
SER G 147
ALA G 146
 None
 1.19A 5eewQ-2nzuG:
undetectable
5eewR-2nzuG:
undetectable		 5eewQ-2nzuG:
15.10
5eewR-2nzuG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 10 SER G 147
ALA G 146
ALA G 145
HIS G 131
ILE G 121
 None
 1.17A 5eexF-2nzuG:
undetectable
5eexG-2nzuG:
undetectable		 5eexF-2nzuG:
15.10
5eexG-2nzuG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 10 ALA G 145
HIS G 131
ILE G 121
SER G 147
ALA G 146
 None
 1.19A 5eexO-2nzuG:
undetectable
5eexP-2nzuG:
undetectable		 5eexO-2nzuG:
15.10
5eexP-2nzuG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 10 SER G 147
ALA G 146
ALA G 145
HIS G 131
ILE G 121
 None
 1.17A 5eeyF-2nzuG:
undetectable
5eeyG-2nzuG:
undetectable		 5eeyF-2nzuG:
15.10
5eeyG-2nzuG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 10 ALA G 145
HIS G 131
ILE G 121
SER G 147
ALA G 146
 None
 1.19A 5eeyO-2nzuG:
undetectable
5eeyP-2nzuG:
undetectable		 5eeyO-2nzuG:
15.10
5eeyP-2nzuG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 10 SER G 147
ALA G 146
ALA G 145
HIS G 131
ILE G 121
 None
 1.17A 5eezF-2nzuG:
undetectable
5eezG-2nzuG:
undetectable		 5eezF-2nzuG:
15.10
5eezG-2nzuG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 10 ALA G 145
HIS G 131
ILE G 121
SER G 147
ALA G 146
 None
 1.19A 5eezO-2nzuG:
undetectable
5eezP-2nzuG:
undetectable		 5eezO-2nzuG:
15.10
5eezP-2nzuG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 10 SER G 147
ALA G 146
ALA G 145
HIS G 131
ILE G 121
 None
 1.16A 5ef0F-2nzuG:
undetectable
5ef0G-2nzuG:
undetectable		 5ef0F-2nzuG:
15.10
5ef0G-2nzuG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 10 ALA G 145
HIS G 131
ILE G 121
SER G 147
ALA G 146
 None
 1.19A 5ef0O-2nzuG:
undetectable
5ef0P-2nzuG:
undetectable		 5ef0O-2nzuG:
15.10
5ef0P-2nzuG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 10 SER G 147
ALA G 146
ALA G 145
HIS G 131
ILE G 121
 None
 1.16A 5ef1F-2nzuG:
undetectable
5ef1G-2nzuG:
undetectable		 5ef1F-2nzuG:
15.10
5ef1G-2nzuG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 10 ALA G 145
HIS G 131
ILE G 121
SER G 147
ALA G 146
 None
 1.19A 5ef1O-2nzuG:
undetectable
5ef1P-2nzuG:
undetectable		 5ef1O-2nzuG:
15.10
5ef1P-2nzuG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 10 SER G 147
ALA G 146
ALA G 145
HIS G 131
ILE G 121
 None
 1.16A 5ef2F-2nzuG:
undetectable
5ef2G-2nzuG:
undetectable		 5ef2F-2nzuG:
15.10
5ef2G-2nzuG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 10 ALA G 145
HIS G 131
ILE G 121
SER G 147
ALA G 146
 None
 1.20A 5ef2O-2nzuG:
undetectable
5ef2P-2nzuG:
undetectable		 5ef2O-2nzuG:
15.10
5ef2P-2nzuG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 10 SER G 147
ALA G 146
ALA G 145
HIS G 131
ILE G 121
 None
 1.16A 5ef3F-2nzuG:
undetectable
5ef3G-2nzuG:
undetectable		 5ef3F-2nzuG:
15.10
5ef3G-2nzuG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 10 ALA G 145
HIS G 131
ILE G 121
SER G 147
ALA G 146
 None
 1.19A 5ef3O-2nzuG:
undetectable
5ef3P-2nzuG:
undetectable		 5ef3O-2nzuG:
15.10
5ef3P-2nzuG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 12 TYR G 161
PHE G  74
LEU G  78
SER G 147
VAL G  65
 None
BG6  G1092 (-3.3A)
None
None
None
 1.43A 5h1eA-2nzuG:
0.0		 5h1eA-2nzuG:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 8 ILE G 272
VAL G 290
ILE G 148
ILE G 318
ASP G 160
 None
None
None
None
SO4  G 945 ( 4.2A)
 1.42A 5hi2A-2nzuG:
undetectable		 5hi2A-2nzuG:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 11 ILE G 191
TYR G 161
ILE G 159
ILE G 121
ILE G  82
 None
 1.07A 5hw8A-2nzuG:
undetectable
5hw8D-2nzuG:
undetectable		 5hw8A-2nzuG:
17.33
5hw8D-2nzuG:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 12 ILE G  73
ILE G 121
LEU G  95
VAL G  65
ILE G  67
 BG6  G1092 (-4.4A)
None
None
None
None
 0.96A 5mueA-2nzuG:
1.5		 5mueA-2nzuG:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B4Y_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 10 MET G 112
LEU G 109
VAL G 142
MET G 309
THR G 306
 None
 1.35A 6b4yA-2nzuG:
1.3		 6b4yA-2nzuG:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		4 / 7 ILE G  94
VAL G  63
ALA G  86
THR G  87
 None
 0.84A 6cduC-2nzuG:
undetectable
6cduD-2nzuG:
undetectable		 6cduC-2nzuG:
20.76
6cduD-2nzuG:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		4 / 8 ILE G  94
VAL G  63
ALA G  86
THR G  87
 None
 0.92A 6cduD-2nzuG:
undetectable
6cduE-2nzuG:
undetectable		 6cduD-2nzuG:
20.76
6cduE-2nzuG:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		4 / 7 ALA G  86
THR G  87
ILE G  94
VAL G  63
 None
 0.86A 6cduF-2nzuG:
undetectable
6cduJ-2nzuG:
undetectable		 6cduF-2nzuG:
20.76
6cduJ-2nzuG:
20.76