SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nzx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE
(Helicobacter
pylori) 		5 / 11 ASN A  73
PHE A  91
GLY A  94
TYR A  92
PHE A 335
 None
 1.37A 1l5rA-2nzxA:
8.5		 1l5rA-2nzxA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE
(Helicobacter
pylori) 		4 / 8 SER A 149
PHE A  49
ASN A  44
LEU A 145
 None
 1.11A 1lhvA-2nzxA:
undetectable		 1lhvA-2nzxA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE
(Helicobacter
pylori) 		5 / 9 LEU A 129
VAL A 136
ALA A 141
LEU A 167
PHE A   2
 None
 1.11A 1tbfA-2nzxA:
undetectable		 1tbfA-2nzxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE
(Helicobacter
pylori) 		5 / 12 TYR A  92
THR A  93
GLY A  94
GLU A 249
LYS A 250
 None
None
None
GDP  A3001 (-3.9A)
GDP  A3001 (-2.9A)
 1.16A 2akeA-2nzxA:
undetectable		 2akeA-2nzxA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE
(Helicobacter
pylori) 		3 / 3 PHE A  42
VAL A  30
TRP A  34
 None
 0.85A 2cc8A-2nzxA:
undetectable		 2cc8A-2nzxA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE
(Helicobacter
pylori) 		3 / 3 PHE A  42
VAL A  30
TRP A  34
 None
 0.85A 2ccbA-2nzxA:
undetectable		 2ccbA-2nzxA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE
(Helicobacter
pylori) 		4 / 6 ILE A 338
TYR A  55
ARG A  54
LEU A  47
 None
 0.88A 2einN-2nzxA:
0.0
2einW-2nzxA:
undetectable		 2einN-2nzxA:
20.86
2einW-2nzxA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE
(Helicobacter
pylori) 		3 / 3 HIS A 298
ILE A 260
LEU A 305
 None
 0.68A 2kceA-2nzxA:
undetectable		 2kceA-2nzxA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE
(Helicobacter
pylori) 		3 / 3 PHE A  42
VAL A  30
TRP A  34
 None
 0.85A 2vx9A-2nzxA:
undetectable		 2vx9A-2nzxA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE
(Helicobacter
pylori) 		5 / 12 ALA A  29
LEU A  59
PHE A  66
SER A  67
LEU A  26
 None
 1.28A 3bxoA-2nzxA:
undetectable		 3bxoA-2nzxA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE
(Helicobacter
pylori) 		3 / 3 GLU A  95
GLU A 239
ASN A 240
 None
None
GDP  A3001 (-3.8A)
 0.60A 3lp9B-2nzxA:
undetectable
3lp9D-2nzxA:
undetectable		 3lp9B-2nzxA:
21.14
3lp9D-2nzxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE
(Helicobacter
pylori) 		4 / 8 ASP A 288
VAL A 279
PHE A 198
LEU A 202
 None
 1.08A 4f8hA-2nzxA:
undetectable
4f8hB-2nzxA:
undetectable		 4f8hA-2nzxA:
21.81
4f8hB-2nzxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE
(Helicobacter
pylori) 		4 / 8 ASP A 288
VAL A 279
PHE A 198
LEU A 202
 None
 1.10A 4f8hC-2nzxA:
undetectable
4f8hD-2nzxA:
undetectable		 4f8hC-2nzxA:
21.81
4f8hD-2nzxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE
(Helicobacter
pylori) 		4 / 8 ASP A 288
VAL A 279
PHE A 198
LEU A 202
 None
 1.09A 4f8hD-2nzxA:
undetectable
4f8hE-2nzxA:
undetectable		 4f8hD-2nzxA:
21.81
4f8hE-2nzxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE
(Helicobacter
pylori) 		3 / 3 SER A  52
TYR A  48
PRO A  24
 None
 0.98A 4k8cA-2nzxA:
3.5		 4k8cA-2nzxA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE
(Helicobacter
pylori) 		3 / 3 SER A  52
TYR A  48
PRO A  24
 None
 0.98A 4kbeA-2nzxA:
3.4		 4kbeA-2nzxA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE
(Helicobacter
pylori) 		3 / 3 SER A  52
TYR A  48
PRO A  24
 None
 0.95A 4lbgA-2nzxA:
undetectable		 4lbgA-2nzxA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE
(Helicobacter
pylori) 		3 / 3 SER A  52
TYR A  48
PRO A  24
 None
 0.96A 4lbgB-2nzxA:
undetectable		 4lbgB-2nzxA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE
(Helicobacter
pylori) 		4 / 6 ASN A 314
GLU A 310
TYR A 255
PHE A 278
 None
 1.50A 4twdG-2nzxA:
undetectable
4twdH-2nzxA:
undetectable		 4twdG-2nzxA:
22.48
4twdH-2nzxA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE
(Helicobacter
pylori) 		3 / 3 LYS A 336
LEU A 120
ILE A  50
 None
 0.61A 5kc0A-2nzxA:
undetectable		 5kc0A-2nzxA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE
(Helicobacter
pylori) 		4 / 7 ILE A 262
PHE A 198
LYS A 295
SER A 204
 None
 1.27A 5nr3A-2nzxA:
undetectable		 5nr3A-2nzxA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE
(Helicobacter
pylori) 		4 / 5 LEU A  69
LEU A  51
THR A 337
ARG A 121
 None
 1.10A 6ew0F-2nzxA:
undetectable		 6ew0F-2nzxA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE
(Helicobacter
pylori) 		4 / 6 LEU A  69
LEU A  51
THR A 337
ARG A 121
 None
 1.10A 6ew0G-2nzxA:
undetectable		 6ew0G-2nzxA:
11.08